Patents by Inventor Hiroshi MOTONARI

Hiroshi MOTONARI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of measuring insulin resistance with fatty acid combustion, and composition used herein
    Patent number: 10444229
    Abstract: This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method. A method for measuring insulin resistance of a test act comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a C12-38 fatty acid labeled with at least one isotope of C, wherein the C12-38 fatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air, (a) intravenously administering the composition to a test subject and collecting expired air; and (b) determining the ratio of labeled CO2 amount to unlabeled CO2 amount contained in the expired air or the ratio of labeled CO2 amount to total CO2 amount contained in the expired air.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 15, 2019
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Hiroshi Motonari, Tetsuya Sato
  • Method of Measuring Insulin Resistance with Fatty Acid Combustion, and Composition Used Herein
    Publication number: 20160146791
    Abstract: This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method. A method for measuring insulin resistance of a test act comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a C12-38 fatty acid labeled with at least one isotope of C, wherein the C12-38 fatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air, (a) intravenously administering the composition to a test subject and collecting expired air; and (b) determining the ratio of labeled CO2 amount to unlabeled CO2 amount contained in the expired air or the ratio of labeled CO2 amount to total CO2 amount contained in the expired air.
    Type: Application
    Filed: March 13, 2014
    Publication date: May 26, 2016
    Inventors: Makoto INADA, Jun-ichi KUNIZAKI, Kazuki TOBITA, Hiroshi MOTONARI, Tetsuya SATO