Patents by Inventor Hiroshi Murao
Hiroshi Murao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9475376Abstract: Annular liquid chamber resonance in an inverted type liquid sealed mount is controlled without using flow resistance. In an engine mount including a secondary liquid chamber located in an upper position, a primary liquid chamber located in a lower position, a main body section of an insulator projecting upwardly in substantially a chevron shape, and an annular liquid chamber formed around the main body section, a control projection is provided on an outside wall of the main body section to project upwardly and configured to produce elastic body resonance in the vicinity of a resonance frequency of annular liquid chamber resonance. With this construction, the annular liquid chamber resonance is controllable by the elastic body resonance of the control projection, and the control projection is increased in size so as to endure flow resistance whereby to improve durability.Type: GrantFiled: December 18, 2013Date of Patent: October 25, 2016Assignee: YAMASHITA RUBBER KABUSHIKI KAISHAInventors: Yukinobu Hirano, Hiroshi Murao
-
Patent number: 9346850Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.Type: GrantFiled: March 11, 2014Date of Patent: May 24, 2016Assignee: KANEKA CORPORATIONInventors: Hiroshi Murao, Ken-ichiro Morio, Masaru Mitsuda
-
Publication number: 20150328969Abstract: Annular liquid chamber resonance in an inverted type liquid sealed mount is controlled without using flow resistance. In an engine mount including a secondary liquid chamber located in an upper position, a primary liquid chamber located in a lower position, a main body section of an insulator projecting upwardly in substantially a chevron shape, and an annular liquid chamber formed around the main body section, a control projection is provided on an outside wall of the main body section to project upwardly and configured to produce elastic body resonance in the vicinity of a resonance frequency of annular liquid chamber resonance. With this construction, the annular liquid chamber resonance is controllable by the elastic body resonance of the control projection, and the control projection is increased in size so as to endure flow resistance whereby to improve durability.Type: ApplicationFiled: December 18, 2013Publication date: November 19, 2015Applicant: YAMASHITA RUBBER KABUSHIKI KAISHAInventors: Yukinobu Hirano, Hiroshi Murao
-
Publication number: 20140288268Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.Type: ApplicationFiled: March 11, 2014Publication date: September 25, 2014Applicant: KANEKA CORPORATIONInventors: Hiroshi MURAO, Ken-ichiro MORIO, Masaru MITSUDA
-
Patent number: 8716439Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.Type: GrantFiled: July 31, 2006Date of Patent: May 6, 2014Assignee: Kaneka CorporationInventors: Hiroshi Murao, Ken-ichiro Morio, Masaru Mitsuda
-
Publication number: 20090069538Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.Type: ApplicationFiled: July 31, 2006Publication date: March 12, 2009Inventors: Hiroshi Murao, Ken-ichiro Morio, Masaru Mitsuda
-
Patent number: 7307184Abstract: The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the ?-position to prepare oxazolidinone derivatives of ?-hydroxyethylamine compounds having an inverted steric configuration at the ?-position carbon, which comprises introducing a step of treating in contact with water with heating under acidic to neutral conditions into the process. Also, the present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the ?-position to prepare ?-hydroxyethylamine compounds having an inverted steric configuration at the ?-position carbon, which comprises subjecting the oxazolidinone derivatives prepared as described above to a step of treating in contact with water under basic conditions.Type: GrantFiled: May 23, 2002Date of Patent: December 11, 2007Assignee: Kaneka CorporationInventors: Hiroshi Murao, Koki Yamashita, Toshihiro Takeda, Yasuyoshi Ueda
-
Publication number: 20070010689Abstract: The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3?-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.Type: ApplicationFiled: August 18, 2004Publication date: January 11, 2007Inventors: Shingo Matsumoto, Hiroshi Murao, Takao Yamaguchi, Masashi Izumida, Yasuyoshi Ueda
-
Publication number: 20060135784Abstract: The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: treating N-protected-3-amino-2-hydroxypropionic acid derivatives (2) having a steric configuration at 2-position carbon reverse to that of derivatives (1) with a leaving group-introducing agent to convert into N-protected-3-aminopropionic acid derivatives (3), then treating the derivatives with a basic substance to convert into substituted-3-amino-2-hydroxypropionic acid derivatives (4) having an inverted steric configuration at 2-position carbon, and then converting the derivatives into 3-amino-2-hydroxypropionic acid derivatives (1).Type: ApplicationFiled: February 17, 2006Publication date: June 22, 2006Inventors: Hiroshi MURAO, Koki Yamashita, Toshihiro Takeda, Yasuyoshi Ueda
-
Patent number: 7057066Abstract: The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: treating N-protected-3-amino-2-hydroxypropionic acid derivatives (2) having a steric configuration at 2-position carbon reverse to that of derivatives (1) with a leaving group-introducing agent to convert into N-protected-3-aminopropionic acid derivatives (3), then treating the derivatives with a basic substance to convert into substituted-3-amino-2-hydroxypropionic acid derivatives (4) having an inverted steric configuration at 2-position carbon, and then converting the derivatives into 3-amino-2-hydroxypropionic acid derivatives (1).Type: GrantFiled: June 26, 2001Date of Patent: June 6, 2006Assignee: Kaneka CorporationInventors: Hiroshi Murao, Koki Yamashita, Toshihiro Takeda, Yasuyoshi Ueda
-
Publication number: 20040181074Abstract: The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the &bgr;-position to prepare oxazolidinone derivatives of &bgr;-hydroxyethylamine compounds having an inverted steric configuration at the &bgr;-position carbon, which comprises introducing a step of treating in contact with water with heating under acidic to neutral conditions into the process. Also, the present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the &bgr;-position to prepare &bgr;-hydroxyethylamine compounds having an inverted steric configuration at the &bgr;-position carbon, which comprises subjecting the oxazolidinone derivatives prepared as described above to a step of treating in contact with water under basic conditions.Type: ApplicationFiled: January 26, 2004Publication date: September 16, 2004Inventors: Hiroshi Murao, Koki Yamashita, Toshihiro Takeda, Yasuyoshi Ueda
-
Publication number: 20040049074Abstract: The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises:Type: ApplicationFiled: January 28, 2003Publication date: March 11, 2004Inventors: Hiroshi Murao, Koki Yamashita, Toshihiro Takeda, Yasuyoshi Ueda
-
Publication number: 20020169337Abstract: A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided.Type: ApplicationFiled: May 13, 2002Publication date: November 14, 2002Applicant: Kaneka CorporationInventors: Yasuyoshi Ueda, Hiroshi Murao, Takeshi Kondo, Noboru Ueyama, Hajime Manabe, Kenji Yoneda, Akira Nishiyama
-
Publication number: 20020103399Abstract: An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized.Type: ApplicationFiled: December 27, 2001Publication date: August 1, 2002Inventors: Koki Yamashita, Kenji Inoue, Koichi Kinoshita, Yasuyoshi Ueda, Hiroshi Murao
-
Publication number: 20020082450Abstract: An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized.Type: ApplicationFiled: December 27, 2001Publication date: June 27, 2002Inventors: Koki Yamashita, Kenji Inoue, Koichi Kinoshita, Yasuyoshi Ueda, Hiroshi Murao
-
Patent number: 6407281Abstract: A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided.Type: GrantFiled: August 25, 2000Date of Patent: June 18, 2002Assignee: Kaneka CorporationInventors: Yasuyoshi Ueda, Hiroshi Murao, Takeshi Kondo, Noboru Ueyama, Hajime Manabe, Kenji Yoneda, Akira Nishiyama
-
Patent number: 6400517Abstract: A magnetic media processing device including an encoder for producing an output for a predetermined distance in a conveyance distance of a magnetic media on conveyance, a road circuit device for reading magnetic data stored in the magnetic media in synchronizing the output from the encoder to be processed as to its waveforms to produce read data, and an arithmetic device for converting a data length to data of a distance based on a time component of a data length of the read data of the read circuit device by employing the output signal from the encoder to read data based on distance data, wherein the arithmetic device compensates the process delay time in a time component of read data produced from the read circuit device when the arithmetic device converts the data length into the data of distance.Type: GrantFiled: July 14, 2000Date of Patent: June 4, 2002Assignee: Omron CorporationInventor: Hiroshi Murao
-
Patent number: 6372941Abstract: An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized. A method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids or salts thereof is disclosed which comprises halogenating the hydroxyl group of a &bgr;-hydroxy-&agr;-aminocarboxylic acid (in which the basicity of the amino group in &agr;-position is not masked by the presence of a substituent on said amino group) or a salt thereof with an acid with a halogenating agent.Type: GrantFiled: August 16, 1999Date of Patent: April 16, 2002Assignee: Kaneka CorporationInventors: Koki Yamashita, Kenji Inoue, Koichi Kinoshita, Yasuyoshi Ueda, Hiroshi Murao
-
Patent number: 6344572Abstract: The present invention provides a production method of high quality threo-1,2-epoxy-3-amino-4-phenylbutane derivatives (1) on a commercial scale in a simple, easy and efficient manner and with very high productivity, which comprises treating a threo-1-halo-2-hydroxy-3-amino-4-phenylbutane derivative (2) with a base in a polar organic solvent or a solvent composed of a polar organic solvent and water, and adding the resulting reaction mixture to water to thereby cause the resulting threo-1,2-epoxy-3-amino-4-phenylbutane derivative (1) to crystallize out.Type: GrantFiled: November 17, 2000Date of Patent: February 5, 2002Assignee: Kaneka CorporationInventors: Katsuji Maehara, Yukinori Tokuda, Hiroshi Murao, Yasuyoshi Ueda
-
Patent number: 6320072Abstract: This invention provides a method of isolating N-protected-S-phenylcysteine (1) of high purity, expediently, efficiently and in good yield, which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of water. wherein R1 represents an amino-protecting group; R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group.Type: GrantFiled: December 14, 2000Date of Patent: November 20, 2001Assignee: Kaneka CorporationInventors: Yasuyoshi Ueda, Hiroshi Murao, Koki Yamashita, Koichi Kinoshita