Abstract: By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.

Abstract: An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.

Abstract: There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.

Abstract: An antibiotic SF2487 substance having the formula (I) 1

Abstract: By culturing Lysobacter sp.

Abstract: As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I) wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.

Abstract: This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.

Abstract: Receivers 14 and 16 comprise mixers 14b and 16b for mixing reception signals of receiver antennas 14a and 16a with a transmission signal to generate beat signals B1 and B2, respectively. Signal processing section 20 performs the Fourier transformation of beat signals B1 and B2 supplied from receivers 14 and 16 to obtain the phases of beat signals B1 and B2 and then obtain the azimuth based on the difference of these phases.

Abstract: Beat signals of respective receiver channels CH1 and CH2, produced by mixing their receiving signals with a transmission signal, are subjected to Fourier transformation to detect the frequency and phase of peak frequency components in both an ascending-section where the frequency of the transmission increases and a descending-section where the frequency of the transmission decreases. Based on peak frequency components derived from the same target, phase differences .DELTA..phi.u(i) and .DELTA..phi.d(j) between receiver channels CH1 and CH2 in the ascending- and descending-sections (steps 210-230). Relative relationship between the transmission signal and the receiving signal is judged based on the signs of the phase differences. Respective peak frequencies fu(i) and fd(j), detected as absolute values of frequency differences between the transmission signal and the receiving signal, are given sings in accordance with the judgement result.

Abstract: An FM-CW radar which is suitable for automotive anti-collision systems, for example, is provided. This radar outputs a radar signal in the form of a triangular wave whose frequency is increased at a given rate and decreased at a given rate. A receiver receives a wave reflected from a target to produce a beat signal and takes the Fourier transform of the beat signal to determine peak frequency components thereof showing peaks in a frequency spectrum. The receiver also determines phases of the peak frequency components and selects at least one from the peak frequency components in a frequency-rising range wherein the frequency of the radar signal is increased and at least one from the peak frequency components in a frequency-falling range wherein the frequency of the radar signal is decreased which show substantially the same phase to pair them for determining the distance to and relative speed of the target based on the frequency of the paired peak frequency components.

Abstract: As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof. Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C.

Abstract: A Doppler-effect speed detecting apparatus for detecting a ground speed of a motor vehicle, including a transmitter, a receiver for receiving a portion of a wave transmitted by the transmitter and reflected by a road surface, a circuit for detecting an output level of the receiver, and a ground-speed determining device for determining the vehicle ground speed, on the basis of the frequencies of the transmitted and received waves, according to a predetermined first rule when the output level of said receiver is higher than a predetermined threshold value, and according to a predetermined second rule different from the first rule when the output level is not higher than the threshold value.

Abstract: A Doppler-effect speed detecting apparatus for detecting a ground speed of a vehicle, including a transmitter for transmitting a wave towards the ground surface, a receiver for receiving the wave reflected by the ground surface, and an output device for producing an output indicative of the ground speed according to the frequencies of the transmitted and reflected waves. The apparatus further includes a device for determining presence or absence of abnormality relating to the output of the output device, on the basis of an output level of the receiver as well as a speed difference between the ground speed obtained by the output device and an estimated vehicle speed which is obtained on the basis of rotating speeds of the vehicle wheels.

Abstract: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.

Abstract: In this invention, a new microbial strain which is a strain of Actinomycetes and belongs to the genus Actinomadura, namely Actinomadura sp. MI215-NF3 strain is cultured, and MI215-NF3 substance, a novel antibiotic classifiable as a polyether antibiotic, is recovered from the resultant culture. MI215-NF3 substance and its salts obtained according to this invention are useful for therapeutic treatment of chicken coccidiosis and also have useful antibacterial activities against certain species of bacteria.

Abstract: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.

Abstract: Benastatins A and B which are novel and physiologically active substances having the formula ##STR1## wherein R represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, exhibit a potent immunomodifier activity, a glutathione transferase inhibition activity and an anti-microorganism activity and are therefore extremely useful for various drugs.

Abstract: A new antibiotic, named Conagenin, is provided which can exhibit useful carcinostatic or antitumor activities on carcinomas and tumors, particularly malignant tumors, of mammalian animals including man. Conagenin can be produced by fermentation of microorganisms of genus Streptomyces, typically Streptomyces roseosporus MI696-AF3 strain identified under the deposit number FERM BP-2738. Conagenin has formula (I) and is useful for medicinal purposes, particularly as carcinostatic agent or antitumor agent for inhibiting carcinomas and malignant tumors of mammalian animals, including man.

Abstract: As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.

Abstract: New physiologically active substances, named probestin and prostatin, respectively, are produced from a new microorganism, Streptomyces azureus MH663-2F6 strain identified as FERM P-9541 or FERM BP-1963. Probestin and prostatin have an activity inhibitory to aminopeptidase M and also have immunopotentiating properties.