Patents by Inventor Hiroshi NISHIMASU

Hiroshi NISHIMASU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL STRUCTURE OF CRISPR CPF1
    Publication number: 20190264186
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: January 23, 2017
    Publication date: August 29, 2019
    Applicants: The Broad Institute Inc., Massachusetts Institute of Technology, University of Tokyo, The USA, As Represented by The Secretary Department of Health and Human Services
    Inventors: Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Ian Slaymaker, Yinqing Li, Iana Fedorova, Kira Makarova, Linyi Gao, Eugene Koonin, Feng Zhang, Osamu Nureki
  • Fused pyrazole derivative having autotaxin inhibitory activity
    Patent number: 10189843
    Abstract: The present invention provides a compound of formula (1), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 29, 2019
    Assignees: THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY, SHIONOGI & CO., LTD.
    Inventors: Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Mitsuyasu Kawaguchi, Osamu Nureki, Ryuichiro Ishitani, Hiroshi Nishimasu, Junken Aoki, Chiaki Fujikoshi, Manabu Katou, Masahide Odan, Nobuyuki Tanaka, Yusuke Tateno, Junji Yamane
  • Pyrimidinone derivative having autotaxin-inhibitory activity
    Patent number: 10183949
    Abstract: A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: January 22, 2019
    Assignees: THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY, SHIONOGI & CO., LTD.
    Inventors: Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Mitsuyasu Kawaguchi, Osamu Nureki, Ryuichiro Ishitani, Hiroshi Nishimasu, Junken Aoki, Nobuyuki Tanaka, Yasuhiko Kanda, Yoshiyuki Kioi, Yusuke Tateno, Shiro Kida, Junji Yamane
  • ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, ENZYMES AND GUIDE SCAFFOLDS OF CAS9 ORTHOLOGS AND VARIANTS FOR SEQUENCE MANIPULATION
    Publication number: 20180312824
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Application
    Filed: December 12, 2017
    Publication date: November 1, 2018
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li
  • MODIFIED FNCAS9 PROTEIN AND USE THEREOF
    Publication number: 20180201912
    Abstract: The present invention provides a protein comprising a sequence containing any one of the amino acid sequences of the following (a) to (f) and having RNA-guided DNA endonuclease activity.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 19, 2018
    Applicant: The University of Tokyo
    Inventors: Osamu NUREKI, Hiroshi NISHIMASU, Hisato HIRANO, Ryuichiro ISHITANI
  • PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY
    Publication number: 20170158704
    Abstract: A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.
    Type: Application
    Filed: February 24, 2017
    Publication date: June 8, 2017
    Applicants: The University of Tokyo, TOHOKU UNIVERSITY, Shionogi & Co., Ltd.
    Inventors: Tetsuo NAGANO, Takayoshi OKABE, Hirotatsu KOJIMA, Mitsuyasu KAWAGUCHI, Osamu NUREKI, Ryuichiro ISHITANI, Hiroshi NISHIMASU, Junken AOKI, Nobuyuki TANAKA, Yasuhiko KANDA, Yoshiyuki KIOI, Yusuke TATENO, Shiro KIDA, Junji YAMANE
  • FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
    Publication number: 20160376278
    Abstract: The present invention provides a compound of formula (1), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.
    Type: Application
    Filed: February 26, 2015
    Publication date: December 29, 2016
    Applicants: The University of Tokyo, TOHOKU UNIVERSITY, Shionogi & Co., Ltd.
    Inventors: Tetsuo NAGANO, Takayoshi OKABE, Hirotatsu KOJIMA, Mitsuyasu KAWAGUCHI, Osamu NUREKI, Ryuichiro ISHITANI, Hiroshi NISHIMASU, Junken AOKI, Chiaki FUJIKOSHI, Manabu KATOU, Masahide ODAN, Nobuyuki TANAKA, Yusuke TATENO, Junji YAMANE
  • SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
    Publication number: 20160355797
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 8, 2016
    Inventors: Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
  • CRISPR-CAS SYSTEMS, CRYSTAL STRUCTURE AND USES THEREOF
    Publication number: 20160340660
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.
    Type: Application
    Filed: June 2, 2016
    Publication date: November 24, 2016
    Inventors: Feng Zhang, Osamu NUREKI, Hiroshi NISHIMASU, Ryuichiro ISHITANI
  • 8-SUBSTITUTED IMIDAZOPYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
    Publication number: 20160002247
    Abstract: A compound of formula (I) wherein variables are as defined herein having an autotaxin inhibitory effect and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Applicants: THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY, Shionogi & Co., Ltd.
    Inventors: Tetsuo NAGANO, Takayoshi OKABE, Hirotatsu KOJIMA, Mitsuyasu KAWAGUCHI, Osamu NUREKI, Ryuichiro ISHITANI, Hiroshi NISHIMASU, Junken AOKI, Nobuyuki TANAKA, Chiaki FUJIKOSHI, Yusuke TATENO, Toshihiro WADA