Abstract: An objective is to provide screening methods for substances having an activity of promoting maturation into hemocytes. It was revealed that in the maturation process of erythrocytes and platelets, RP S19 multimers are released to the outside of the cell and act on the C5a receptors of erythroblasts and megakaryocytes, thereby causing maturation of erythroblasts and megakaryocytes to erythrocytes and platelets. Based on such findings, the present invention provides methods of screening for substances having an activity of promoting maturation into hemocytes by targeting the RP S19 multimers and C5a receptors. The screening methods of the present invention can detect hemocyte maturation using an increase of the R4 RGS family as an indicator. Furthermore, the present invention provides agents for promoting hemocyte maturation, which comprise RP S19 multimers and a substance having an activity of promoting maturation into hemocytes as useful components.

Abstract: An objective is to provide screening methods for substances having an activity of promoting maturation into hemocytes. It was revealed that in the maturation process of erythrocytes and platelets, RP S19 multimers are released to the outside of the cell and act on the C5a receptors of erythroblasts and megakaryocytes, thereby causing maturation of erythroblasts and megakaryocytes to erythrocytes and platelets. Based on such findings, the present invention provides methods of screening for substances having an activity of promoting maturation into hemocytes by targeting the RP S19 multimers and C5a receptors. The screening methods of the present invention can detect hemocyte maturation using an increase of the R4 RGS family as an indicator. Furthermore, the present invention provides agents for promoting hemocyte maturation, which comprise RP S19 multimers and a substance having an activity of promoting maturation into hemocytes as useful components.

Abstract: There are provided a game system, game machine, game data distribution machine, image data distribution system and computer available information which can synchronize clock signals between a plurality of devices. A game data distribution machine (100) includes a machine clock generation section (180), a clock selection section (160) and a clock generation section (120). By using these sections, a reference clock is generated as a basis of synchronization. The game data distribution machine also includes a clock and data superposition section (170) which superposes the reference clock on a game data, the superposed game data being then distributed to game machines (200). Each of the game machines (200) includes a clock and data separation section (272) which extracts the reference clock from the superposed data and a clock generation section (220) which generates an operation clock for each of game execution means including a game data production section (290) and so on, based on the reference clock.