Patents by Inventor Hiroshi Ohrui

Hiroshi Ohrui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4' -C-substituted-2-haloadenosine derivative
    Patent number: 8039614
    Abstract: The present invention provides a method for producing a 4?-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen or a phosphoryl group. The present invention also provides the derivative, and a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: October 18, 2011
    Assignee: Yamasa Corporation
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4?-c-substituted-2-haloadenosine derivative
    Patent number: 7625877
    Abstract: The present invention provides a 4?-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue. The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: December 1, 2009
    Assignee: Yamasa Corporation
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4' -C-substituted-2-haloadenosine derivative
    Publication number: 20090234110
    Abstract: The present invention provides a method for producing a 4?-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen or a phosphoryl group. The present invention also provides the derivative, and a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
    Type: Application
    Filed: May 20, 2009
    Publication date: September 17, 2009
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4' -C-substituted-2-haloadenosine derivative
    Publication number: 20080153774
    Abstract: The present invention provides a 4?-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 26, 2008
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4?-C-substituted-2-haloadenosine derivative
    Patent number: 7339053
    Abstract: The present invention provides a 4?-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. Such derivative is useful as medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: March 4, 2008
    Assignee: Yamasa Corporation
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4' -C-substituted-2-haloadenosine derivative
    Publication number: 20050215512
    Abstract: The present invention provides a 4?-C-substituted-2-haloadenosine derivative represented by the following formula (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 29, 2005
    Inventors: Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
  • 4?-C-ethynyl pyrimidine nucleosides and pharmaceutical compositions thereof
    Patent number: 6403568
    Abstract: The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: June 11, 2002
    Assignee: Yamasa Corporation
    Inventors: Hiroshi Ohrui, Shiro Shigeta, Eiichi Kodama, Haruhiko Machida, Satoru Kohgo, Hiroaki Mitsuya
  • 4'-C-ethynyl pyrimidine nucleoside compounds
    Publication number: 20020022722
    Abstract: The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: February 21, 2002
    Inventors: Hiroshi Ohrui, Shiro Shigeta, Eiichi Kodama, Haruhiko Machida, Satoru Kohgo, Hiroaki Mitsuya
  • 4?-C-ethynyl purine nucleoside compounds
    Patent number: 6333315
    Abstract: The invention provides 4′-C-ethynyl purine nucleosides represented by formula [I]: wherein B represents a base selected from the group consisting of purine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: December 25, 2001
    Assignee: Yamasa Corporation
    Inventors: Hiroshi Ohrui, Eiichi Kodama, Satoru Kohgo, Hiroaki Mitsuya, Masao Matsuoka, Kenji Kitano
  • 4?-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions
    Patent number: 6291670
    Abstract: The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: September 18, 2001
    Assignee: Yamasa Corporation
    Inventors: Hiroshi Ohrui, Shiro Shigeta, Eiichi Kodama, Haruhiko Machida, Satoru Kohgo, Hiroaki Mitsuya
  • Method for analyzing lipid peroxides using aromatic phosphines
    Patent number: 5061633
    Abstract: A method for analyzing a lipid peroxide, which comprises reacting a lipid peroxide with an aromatic phosphine compound of the formula: ##STR1## wherein each of R.sub.1 to R.sub.3 is an aromatic group, in a solvent, to form an aromatic phosphine oxide and observe any fluorescence of the aromatic phosphine oxide.
    Type: Grant
    Filed: March 7, 1990
    Date of Patent: October 29, 1991
    Assignee: Tosoh Corporation
    Inventors: Hiroshi Meguro, Hiroshi Ohrui, Kazuaki Akasaka
  • Aromatic phosphine oxide compound
    Patent number: 4947000
    Abstract: An aromatic phosphine compound of the formula: ##STR1## wherein each of R.sub.1 to R.sub.3 is an aromatic group, or an oxide thereof.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: August 7, 1990
    Assignee: Tosoh Corporation
    Inventors: Hiroshi Meguro, Hiroshi Ohrui, Kazuaki Akasaka