Abstract: Provided are a cancer therapeutic drug comprising a compound which inhibits GPX4 as an active ingredient, the cancer therapeutic drug treating cancer containing a cancer cell having a suppressed function of a SWI/SNF complex factor detected; and a method for predicting sensitivity of a cancer cell to a GPX4 inhibitor, the method comprising the step of predicting a cancer cell having a suppressed function of a SWI/SNF complex factor detected in the cancer cell, as having sensitivity to the GPX4 inhibitor.

Abstract: A construction machine that can make a depressing force of a bucket during compaction work to be uniform without requiring an operator to perform a complicated operation is provided. A controller 18 determines whether or not compaction work is in progress, calculates a front distance R that represents a distance between a rotational pivot of a boom 4 and a predetermined position B in a back surface of a bucket 6, determines a target velocity of the bucket such that a velocity with which the bucket approaches a leveling target surface decreases with increasing values of the front distance, and, during the compaction work, notifies the operator of details of an operation of operation devices 9a and 9b for achieving the target velocity of the bucket or controls hydraulic actuators 4a to 6a so as to achieve the target velocity of the bucket.

Abstract: To provide a work machine that can maintain the construction precision of semi-automatic control irrespective of excavation depths and differences in soil nature. A controller acquires soil-nature information on the basis of an operation command given to a work implement, a bucket-claw-tip position outputted from a bucket-position measuring device, and a drive load of the work implement outputted from a load measuring device; generates a soil-nature map on the basis of the bucket-claw-tip position, and the soil-nature information; calculates an estimated load that is an estimate of an excavation load on the basis of the soil-nature map and a bucket-claw-tip target position; and corrects the operation command in accordance with the estimated load.

Abstract: A hydraulic excavator including a controller that calculates the positional relationship between a bucket and a target surface and a display device that displays the positional relationship between the bucket and the target surface includes an actuator state sensor that detects the pressure of a hydraulic cylinder. The controller calculates the velocity of the bucket based on the position of a work implement and the operation amount of an operation device and changes the contents of informing by the display device according to the velocity of the bucket, the distance between the bucket and the target surface, and the pressure of the hydraulic cylinder. The display device displays the contents of informing changed by the controller.

Abstract: A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).

Abstract: A compound represented by the following general formula (I) [the symbol in the formula are as defined in the description], a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can he used as an agent for the prevention or treatment of disorders including cancers and cancer metastasis having mutations in RET.

Abstract: A work machine includes: an informing device that informs an operator; an input device for inputting predetermined information; a notification device that gives a notification to a worker around the work machine; a controller; and a communication device that communicates with a mobile terminal carried by the worker.

Abstract: In a wireless information collecting method executed by at least one user terminal device that measures wireless information used in a site survey and a server device that stores the wireless information and performs the site survey, the user terminal device performs a step of periodically measuring a current position and transmitting positioning information indicating the current position to the server device, and a step of measuring the wireless information in accordance with a wireless information measurement number instructed by the server device and transmitting wireless information including a position and time to the server device.

Abstract: In step S11, a color image CIMG is acquired. In step S12, a distance image DIMG is acquired. In step S13, the color image CIMG is projected onto the distance image DIMG. An alignment of the color image CIMG and the distance image DIMG is performed prior to the projection of the color image CIMG. In step S14, it is determined whether or not a basic condition is satisfied. In S15, it is determined whether or not a special condition is satisfied. If a judgement result of the steps S14 or S15 is positive, then in step S16 a first data point and a second data point on the distance image DIMG are associated. If bot of the judgement results of steps S14 and S15 are negative, data points are not associated in step S17.

Abstract: Provided is a method for predicting sensitivity of a cancer cell to a helicase inhibitor, the method comprising the step of: predicting a cancer cell having at least one mutation detected selected from the first group consisting of TTK mutation and RAD 50 mutation, as having sensitivity to a helicase inhibitor, or predicting a cancer cell having at least one mutation detected selected from the second group consisting of RAD 50 mutation, MRE 11 mutation, NBN mutation, DNA 2 mutation and RBBP 8 mutation, as having sensitivity to a helicase inhibitor.

Abstract: A site management system manages the positions of workers and work areas of work machines. The workers can recognize the work areas of the work machines at a work site in which the work machines and the workers carry out work. A site management device is connected to a worker terminal carried by a worker and a work machine processor is mounted on a work machine 1. The site management device generates worker information 360 on the basis of a signal transmitted from the worker terminal and generates work machine information 350 based on a signal transmitted from the work machine processor. Work area information 380 including the position and the work area of a work machine is generated on the basis of the pieces of information 350 and 360 and a work area notification signal is transmitted with the work area information to the worker terminal device.

Abstract: A sensor abnormality estimation device determines whether or not a position and a speed of a sensor-mounted vehicle at an intersection fulfill a predetermined performance condition. When the position and the speed fulfill the performance condition, the sensor abnormality estimation device acquires recognition results obtained by two of a plurality of external sensors, for a target object at a designated position associated with the position of the sensor-mounted vehicle. The sensor abnormality estimation device then acquires a degree of coincidence between the recognition results, and determines that there is an abnormality in at least one of the two external sensors when the degree of coincidence is lower than a predetermined determination value.

Abstract: A hydraulic excavator having a plurality of front implement members, including a bucket, has a controller that controls the work implement by using: excavation assistance control that controls the work implement such that the bucket moves along a predetermined target excavation surface; and deviation prevention control that prevents deviation of the work implement from a predetermined work area by decelerating or stopping operation of a subject front implement member that is included in the plurality of front implement members and that can deviate the work implement from the work area. The controller controls the work implement such that when the controller controls the work implement by using both the excavation assistance control and the deviation prevention control, an operation direction of the bucket approximates to an operation direction of the bucket that is to be generated when the work implement is controlled by using only the excavation assistance control.

Abstract: A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.

Abstract: A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).

Abstract: The line-of-sight direction of an operator is estimated on the basis of the posture of a front work device detected by a posture sensor, and plural display regions are set on a screen of a transparent display on the basis of the estimated line-of-sight direction of the operator. Then, the display position of a display image is calculated in such a manner that the display position is located in the display region corresponding to the kind of the display image in the set plural display regions.

Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.

Abstract: An object recognition apparatus include a storage device and a processor. The storage device stores peripheral information and tolerance information. The tolerance information is information in which the degree of tolerance for the undetected object is represented for each class of the object. The peripheral information is acquired by a sensor device provided in the vehicle. The processor performs object recognition process for recognizing an object around the vehicle. In the object recognition process, the processor identifies the object and its class to be detected based on the peripheral information, and calculates the likelihood that is a parameter representing the probability of detection of the object. Further, the processor calculates a likelihood threshold corresponding to the object based on the tolerance information, and determines whether to output the identification result of the object based on the comparative between the likelihood and the likelihood threshold.

Abstract: Provided is a work machine that, within the limit of not harming dynamic stability, can perform work utilizing the impact generated when a cylinder driving a front work implement collides with a stroke end.

Abstract: Provided are a work point position computing section configured to compute the relative position of a work point set on a bucket with respect to an upper swing structure on the basis of posture information, a target surface setting section configured to set a target surface as a target of excavation work on the basis of design surface information, a primary operation determining section configured to determine which of operations of a boom and an arm is a primary operation as a main operation when the work point is moved along the target surface, and a recommended operation computing section configured to compute a recommended operation amount and a recommended operation direction of a secondary operation as another operation different from the primary operation in the operations of the boom and the arm according to an operation amount and an operation direction of the primary operation.