Abstract: An object of the present invention is to provide a method in which the amount of mannose 5 in a product can be reduced in the production method for the product by cell culture, and a product that is produced by the method. According to the present invention, there is provided a production method for a product, including culturing cells in a culture container, in which the culturing is a perfusion culture method, Expressions (1) to (5) are satisfied in a production period of a product after reaching a target viable cell density, a variation of VCD during the production period is ±20% or less with respect to an average viable cell density during the production period, and a variation of VCV during the production period is ±20% or less with respect to an average value of the VCV during the production period. 0?Gln-C?2.5??Expression (1) 0.5?Gluc-C?8.0??Expression (2) 1.0?NH4-C?8.0??Expression (3) 50?VCD?300??Expression (4) 0.6×105?VCV?4.

Abstract: A method including: connecting, through a coupling line, a culture section where a culture step, in which cells are cultured in a culture liquid stored in a culture tank and the cells are removed from the culture liquid to obtain a culture supernatant liquid containing a product of the cells, is performed and a purification section where a purification step, in which the product is purified from the culture supernatant liquid to obtain an active pharmaceutical ingredient of a biopharmaceutical, is performed, to allow the culture supernatant liquid to flow into the purification section from the culture section through the coupling line; connecting a flexible single-use tank having an accommodation capacity of 0.2 times to 10 times an amount of the culture liquid in the culture tank to a branch line provided between the culture section and the purification section; and temporarily storing the culture supernatant liquid in the tank.

Abstract: An object of the present invention is to provide a method for producing a product by cell culture, which makes it possible to suppress the clogging of an exhaust filter due to bubbles generated on an upper surface of a culture solution, and a cell culture device that makes it possible to suppress the clogging of an exhaust filter due to bubbles generated on an upper surface of a culture solution. According to the present invention, there is provided a method for producing a product, which includes culturing a cell using a cell culture device to produce a product from the cell, where the cell culture device includes a culture container accommodating a cell suspension containing cells and at least one or more bubble trap containers capable of accumulating bubbles, the one or more bubble trap containers being connected to an outside of the culture container.

Abstract: In the cell culture device, a volume of a space defined by a diaphragm of the diaphragm pump and a plane at an outer edge of the diaphragm is 1 cm3 or more and 20 cm3 or less, in a case where an angle formed by a straight line connecting a foot of a perpendicular line from the apex to the plane to each point in the diaphragm and by the perpendicular line is denoted by an angle A, a thickness H of the diaphragm is within a range of 0.5 mm or more and 1.5 mm or less where the angle A is from 0° to 75°, and in a case where a thickness of the diaphragm at the apex is denoted by HT, the thickness H satisfies a relationship of 1?HT/H?1.75 at any point where the angle A is from 0° to 75°.

Abstract: A transparent electromagnetic wave-shielding filter, containing a support, a conductive layer provided on the support, and a hard coat layer provided on the conductive layer, wherein the conductive layer is formed by subjecting an emulsion layer which contains a silver halide and a binder and is coated on the support, to exposure and developing process, wherein the hard coat layer is formed by coating a coating liquid for forming the hard coat layer with a solvent on the conductive layer, and wherein the emulsion layer contains a compound soluble in the solvent of the coating liquid for forming the hard coat layer.

Abstract: A conductive film producing method includes a metallic silver forming step of exposing and developing a photosensitive material having a 95-?m-thick long support and thereon a silver salt-containing emulsion layer, thereby forming a metallic silver portion to prepare a conductive film precursor, and a smoothing treatment step of subjecting the conductive film precursor to a smoothing treatment to produce a conductive film. In the smoothing treatment, the conductive film precursor is pressed by first and second calender rolls facing each other, and the first calender roll is a resin roll to be brought into contact with the support. The method satisfies the condition of 1/2?P1/P2?1, wherein P1 represents a conveying force applied when the conductive film precursor is introduced to an area where the smoothing treatment step is conducted, and P2 represents a conveying force applied when the smoothing-treated conductive film is discharged from the area.

Abstract: A transparent electromagnetic wave-shielding filter, containing a support, a conductive layer provided on the support, and a hard coat layer provided on the conductive layer, wherein the conductive layer is formed by subjecting an emulsion layer which contains a silver halide and a binder and is coated on the support, to exposure and developing process, wherein the hard coat layer is formed by coating a coating liquid for forming the hard coat layer with a solvent on the conductive layer, and wherein the emulsion layer contains a compound soluble in the solvent of the coating liquid for forming the hard coat layer.

Abstract: A conductive film producing method includes a metallic silver forming step of exposing and developing a photosensitive material having a 95-?m-thick long support and thereon a silver salt-containing emulsion layer, thereby forming a metallic silver portion to prepare a conductive film precursor, and a smoothing treatment step of subjecting the conductive film precursor to a smoothing treatment to produce a conductive film. In the smoothing treatment, the conductive film precursor is pressed by first and second calender rolls facing each other, and the first calender roll is a resin roll to be brought into contact with the support. The method satisfies the condition of ½?P1/P2?1, wherein P1 represents a conveying force applied when the conductive film precursor is introduced to an area where the smoothing treatment step is conducted, and P2 represents a conveying force applied when the smoothing-treated conductive film is discharged from the area.

Abstract: In a method of repairing at least one optical cable, in one repeating span between two adjacent repeaters, which is constituted by a first optical fiber exhibiting positive wavelength dispersion with respect to an optical signal to be transmitted and a second optical fiber which is connected in series with the first optical fiber and exhibits negative wavelength dispersion with respect to the optical signal, an optical cable portion, in the repeating span, which includes a fault point of at least an optical cable in one direction and has a fixed length from a point near one of two adjacent repeaters is cut. At least one repair cable piece constituted by a third optical fiber exhibiting the same positive wavelength dispersion as that of the first optical fiber and a fourth optical fiber which is connected in series with the third optical fiber and exhibits the same negative wavelength dispersion as that of the second optical fiber is inserted and connected in the cut optical cable portion.

Abstract: A remote amplifier of the present invention includes an optical splitter and an optical combiner respectively connected to an input and an output thereof. One end of the split output of the splitter is used as an input port while one end of the combiner is used as an output port. When a fault occurs at a certain point on an optical transmission path, an ODOR (Optical Time Domain Reflect meter) is connected to either one of the input port and output port for evaluating the faulty point.

Abstract: A submarine optical gain equalizer installed on a submarine optical transmission cable 5. The submarine optical gain equalizer comprises a pressure housing 1, in which an optical gain equalizer and n through-fibers are installed. Input and output ports of the optical gain equalizer and the through-fibers are formed in the outside of the pressure housing. The submarine optical gain equalizer equalizes levels of signal light having wavelengths different each other caused by optical fiber amplifiers. In general, one submarine optical gain equalizer is installed for 40 optical fiber amplifiers on a submarine optical cable.

Abstract: A submarine optical gain equalizer installed on a submarine optical transmission cable 5. The submarine optical gain equalizer comprises a pressure housing 1, in which an optical gain equalizer and n through-fibers are installed. Input and output ports of the optical gain equalizer and the through-fibers are formed in the outside of the pressure housing. The submarine optical gain equalizer equalizes levels of signal light having wavelengths different each other caused by optical fiber amplifiers. In general, one submarine optical gain equalizer is installed for 40 optical fiber amplifiers on a submarine optical cable.

Abstract: A submarine optical gain equalizer installed on a submarine optical transmission cable 5 comprises a pressure housing 1, in which an optical gain equalizer and n through-fibers are installed. Input and output ports of the optical gain equalizer and the through-fibers are formed in the outside of the pressure housing. The submarine optical gain equalizer equalizes levels of signal light having wavelengths different from each other caused by optical fiber amplifiers. In general, one submarine optical gain equalizer is installed for every 40 optical fiber amplifiers on a submarine optical cable.

Abstract: A solvent-soluble siloxane polyimide comprising a copolymer obtained by reaction of a diamine compound mixture comprising a diaminopolysiloxane, an alicyclic diamine and an aromatic diamine with an aromatic tetracarboxylic acid anhydride, followed by polyimidization reaction of the resulting polyamic acid forms a heat-resistant adhesive by adding an epoxy resin, a diamine-based curing agent and an organic solvent thereto, The formed adhesives provides a distinguished curling resistance without any warp when the resulting siloxane polyimide soluble in ordinary organic solvents is used as a main component of the adhesive for bonding between a base material and a copper foil of a flexible printed substrate.

Abstract: It is the object of the invention to provide a wavelength stability circuit used in a WDM optical transmission system, in which the spacing of wavelengths between adjacent optical signals are always so controlled as to keep a prescribed value. The two optical signals with different wavelengths are respectively generated by two laser diodes and multiplexed by an optical coupler. A portion of the multiplexed optical signals is supplied to an optical heterodyne detection circuit, where the spacing of the wavelengths between the two optical signals is detected. The spacing of the wavelengths between the optical signals is converted into an electrical signal by an O/E converter and a frequency counter, and the electrical signal is compared with a standard voltage in a comparator.

Abstract: A solvent-soluble siloxane polyimide comprising a copolymer obtained by reaction of a diamine compound mixture comprising a diaminopolysiloxane and an alicyclic diamine with an aromatic tetracarboxylic acid anhydride, followed by polyimidization reaction of the resulting polyamic acid forms a heat-resistant adhesive by adding an epoxy resin, a diamine-based curing agent and an organic solvent thereto, The formed adhesives show a distinguished heat-resistant adhesiveness when the resulting siloxane polyimide soluble in ordinary organic solvents is used as a main component of the adhesive for bonding between a base material and a copper foil of a flexible printed substrate. By further addition of a fluorinated resin to the heat-resistant adhesive, the adhesiveness can be more improved.

Abstract: A reproducing circuit is disclosed having a photo-diode for extracting a signal component of a monitor signal from an electric signal converted from an optical signal using a band pass filter 108 and an envelope detector circuit 111. The output of the photo-diode 106 is smoothed by a capacitor 12 via a buffer amplifier 11. A threshold voltage control circuit 13 converts the smoothed signal voltage with a predetermined ratio to produce a threshold voltage. A discriminator 115 converts the extracted monitor signal component into a binary signal using the threshold voltage as a reference. Since the smoothed voltage varies in accordance with the average intensity of optical signal, the monitor signal can be appropriately converted into a binary signal in accordance with the intensity of optical signal. Further, since the smoothing is performed by a capacitor, the circuit structure can be simplified.

Abstract: An optical modulating and amplifying apparatus includes an optical amplifier and a modulator. In the apparatus, an input optical signal and an excited light are combined with each other to produce an output light signal. The excited light from a laser diode is sensed by a photodiode. The sense signal includes a bias and an amplitude to be respectively detected by a mean value sensor and a modulation signal sensor. A modulation degree of the excited light is computed by a divider. A control signal to develop a predetermined modulation degree is delivered from a control signal generator to a variable gain amplifier. In response to the control signal, the amplifier controls the amplitude of the oscillation signal from an oscillator. A laser diode driver adds a bias to the oscillation signal to drive the laser diode. The modulation degree is kept unchanged regardless of variation in an output level of the excited light so as to achieve the modulation with a high signal-to-noise ratio.

Abstract: A spool valve has a valve housing with a valve bore formed therein, a spool having a land portion slidably accommodated in the valve bore, a control port formed within the valve housing, able to communicate with the valve bore, and opened and closed by the land portion, and an annular groove open at an inner peripheral surface of the valve bore and communicating with the control port. Part of the control port is open over the inner and outer parts, as taken in the widthwise direction, of the annular groove. The degree of opening of the port is variably controlled by the displacement of the land portion.

Abstract: An electromagnetic actuator includes a housing and a pair of stators cooperating with the housing to form a magnetic circuit for a solenoid. Each of the pair of stators has a tubular portion, and the tubular portions of the pair of stators have their one ends disposed in the opposed spaced relation to each other. The solenoid is mounted around the tubular portions of the pair of stators, and an armature is received in the tubular portions of the pair of stators so as to be movable along the axis of the tubular portions. The armature is supplied with a force when an electric current is applied to the solenoid. In order to keep the magnetic resistance of the magnetic circuit to a low level, one of the pair of stators is formed integrally with one end of a tubular body of the housing so that the housing and the one stator constitute a unitary member.