Abstract: A fishing reel that achieves the smooth winding and unwinding of a fishing line is provided. The fishing reel includes a line guide provided with fishing line guide hole which is formed into a rectangular shape viewed from the front of the guide body and a pillar movable in a vertical direction in the vicinity in the anterior posterior direction of the line guide. The pillar is provided with fishing line guide member extending along the axis and the pillar is configured to be movable between a first position where the fishing line is held in the center portion and a second position retracted from the first position. The pillar may assume the first position by moving downwardly for a fishing line winding operation so as to cause the fishing line guide member to guide the fishing line to the center portion of the fishing line guide hole.

Abstract: The present invention provides an identification marker responsive to IFN therapy for renal cell cancer and a means of detecting the same. Namely, a method which comprises preparing a genomic DNA of a human gene or a complementary strand thereof from a specimen of a patient with renal cell cancer, analyzing the DNA sequence of the genomic DNA or the complementary strand thereof to determine the gene polymorphism of the human gene, and evaluating the tumor-suppression effect of IFN therapy on renal cell cancer by using the polymorphism as an indicator.

Abstract: The present invention provides an identification marker responsive to IFN therapy for renal cell cancer and a means of detecting the same. Namely, a method which comprises preparing a genomic DNA of a human gene or a complementary strand thereof from a specimen of a patient with renal cell cancer, analyzing the DNA sequence of the genomic DNA or the complementary strand thereof to determine the gene polymorphism of the human gene, and evaluating the tumor-suppression effect of IFN therapy on renal cell cancer by using the polymorphism as an indicator.

Abstract: A double bearing type reel includes: a reel main body having a pair of side plates; a spool rotatably supported between the side plates; and a fishline guide device reciprocatingly provided between the side plates extending in front of the spool, said fishline guide device winding a fishline parallel around the spool. The fishline guide device includes a fishline guide portion having a lower portion which guides the fishline in a fishline take-up state and an upper portion which guides the fishline in a fishline play-out state. The upper portion is larger in width than the lower portion. The fishline guide device may have a pair of arm portions movably supported to the side plates by outer ends thereof.

Abstract: A reel for fishing is capable of mounting a fishing rod in its leading end in the direction in which a fishline is played out. The reel for fishing has a reel body which is provided with a spool on which the fishline is wound up, a handle to be driven to rotate the spool in the fishline-winding-up direction, and a grip portion to be held integrally with the reel body at the time of actual fishing. An opening is formed in the reel body, which opening is capable of smoothly thumbing the spool along the direction of the thumb which is gripping and holding the grip portion.

Abstract: In a fishing reel, a rotary body (a drive gear) has an accommodating section at the center which includes a round hole and a recess. The accommodating section accommodates the thick annular liner of a brake member in a brake device, and the detection brake body. The liner is made of felt, cork, leather or fiber-reinforced synthetic resin. The detection brake body is in the form of a disk, and is mounted on a shaft, which is a handle shaft. The bottom surface of the recess of the rotary body is formed into the uneven portion. The detection brake body has a through-hole, to which one end portion of the detecting piece is secured, for instance, by spot welding, and the other end portion of the detecting piece is extended so as to be engageable with the uneven portion. When the liner is worn out to a predetermined value, the detecting piece is contacted and engaged with the uneven portion to generate a sound.