Patents by Inventor Hiroshi Tsukiura

Hiroshi Tsukiura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotics produced by fermentation of a novel strain of Streptomyces hygroscopicus
    Patent number: 4504580
    Abstract: Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: March 12, 1985
    Assignee: Bristol-Myers Company
    Inventors: Minoru Hanada, Mitsuaki Tsunakawa, Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • 1-Deamino-1-hydroxy-aminoglycoside compounds, antibacterial compositions and method of use
    Patent number: 4468386
    Abstract: Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.
    Type: Grant
    Filed: August 19, 1982
    Date of Patent: August 28, 1984
    Assignee: Bristol-Myers Company
    Inventors: Minoru Hanada, Mitsuaki Tsunakawa, Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • Process of producing a peptide antibiotic with Bacillus circulans
    Patent number: 4360593
    Abstract: A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: November 23, 1982
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Takeo Miyaki, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • Antibiotic compounds
    Patent number: 4341768
    Abstract: A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: July 27, 1982
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Takeo Miyaki, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • Fermentation process for producing nocardicins A and B
    Patent number: 4320199
    Abstract: The known antibiotic, nocardicin, is produced by submerged aerobic cultivation of Microtetraspora caesia sp. nov. ATCC 31724 or 31725.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: March 16, 1982
    Assignee: Bristol-Myers Company
    Inventors: Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • Production of antibiotics by fermentation of novel strains of Micropolyspora caesia
    Patent number: 4181574
    Abstract: A novel antibiotic complex designated herein as Bu-2313 is produced by fermentation of Micropolyspora sp. A.T.C.C. 31295, 31296, 31297 and 31298. The complex is separated into two bioactive components, Bu-2313A and Bu-2313B, which are structurally related to the streptolydigin-tirandamycin group of antibiotics. They are active against anaerobic bacteria.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: January 1, 1980
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Hiroshi Tsukiura, Koji Tomita
  • Antibiotic compounds
    Patent number: 4169096
    Abstract: A novel antibiotic complex designated herein as Bu-2313 is produced by fermentation of Micropolyspora sp. A.T.C.C. 31295, 31296, 31297 and 31298. The complex is separated into two bioactive components, Bu-2313A and BU-2313B, which are structurally related to the streptolydigin-tirandamycin group of antibiotics. They are active against anaerobic bacteria.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: September 25, 1979
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Hiroshi Tsukiura, Koji Tomita
  • Antibiotic complex
    Patent number: 4108725
    Abstract: A novel aminoglycoside antibiotic complex designated herein as Bu-2183 is produced by fermentation of Pseudomonas sp. strain D946-B83, A.T.C.C. 31086. Complex Bu-2183 is known to consist of at least five components, said components being herein designated Bu-2183 A, A.sub.2, B, C and D. The complex and the individual aminoglycoside components Bu-2183 A, A.sub.2, and B are found to have a broad spectrum of antibacterial activity and are especially useful in inhibiting aminoglycoside-resistant organisms including Pseudomonas species.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: August 22, 1978
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Koji Tomita, Kei-ichi Fujisawa, Hiroshi Tsukiura
  • Glycopeptide antibiotics Bu-2231 A and B and process for producing same
    Patent number: 4051237
    Abstract: A novel water-soluble basic glycopeptide antibiotic complex designated herein as Bu-2231 is produced by fermentation of a Bu-2231-producing strain of Streptoalloteichus hindustanus. Complex Bu-2231 and two of its major components designated herein as Bu-2231 A and B are found to inhibit the growth of various Gram-positive and Gram-negative and acid-fast bacteria as well as certain plant pathogens. The complex and components Bu-2231 A and B are also useful in inhibiting the growth of various tumors in rodents, for example, Walker 256 carcinosarcoma and Lewis Lung carcinoma.
    Type: Grant
    Filed: August 28, 1975
    Date of Patent: September 27, 1977
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Koji Tomita, Hiroshi Tsukiura, Masataka Konishi
  • Fermentation process for producing apramycin and nebramycin factor V'
    Patent number: 4032404
    Abstract: A fermentation process is disclosed for preparing the known aminoglycoside antibiotics apramycin and nebramycin factor V' by culturing Streptoalloteichus hindustanus A.T.C.C. 31217, 31218 or 31219. The so-produced nebramycin factor V' may subsequently be converted to tobramycin by base catalyzed hydrolysis.
    Type: Grant
    Filed: July 14, 1976
    Date of Patent: June 28, 1977
    Assignee: Bristol-Myers Company
    Inventors: Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
  • Fermentation process
    Patent number: 4026766
    Abstract: A fermentation process for preparing capreomycin, a known antibiotic, employing a heretofore unknown microorganism is described, said microorganism being classified as a member of the genus Dactylosporangium and being herein named Dactylosporangium variesporum strain D409-5 (ATCC 31203).
    Type: Grant
    Filed: May 5, 1976
    Date of Patent: May 31, 1977
    Assignee: Bristol-Myers Company
    Inventors: Koji Tomita, Seikichi Kobaru, Minoru Hanada, Hiroshi Tsukiura
  • Antibiotic complex Bu 2183
    Patent number: 4012576
    Abstract: A novel aminoglycoside antibiotic complex designated herein as Bu-2183 is produced by fermentation of Pseudomonas sp. strain D946-B83, A.T.C.C. 31086. Complex Bu-2183 is known to consist of at least five components, said components being herein designated Bu-2183 A, A.sub.2, B, C and D. The complex and the individual aminoglycoside components Bu-2183 A, A.sub.2, and B are found to have a broad spectrum of antibacterial activity and are especially useful in inhibiting aminoglycoside-resistant organisms including Pseudomonas species.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: March 15, 1977
    Assignee: Bristol-Myers Company
    Inventors: Hiroshi Kawaguchi, Koji Tomita, Kei-Ichi Fujisawa, Hiroshi Tsukiura