Patent number: 6222035
Abstract: [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A2A receptors (for example, Parkinson's disease or senile dementia):
wherein R1 represents substituted or unsubstituted aryl, or the like; R2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R3 represents hydrogen, halogen, XR10 (wherein X represents O or S; and R10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.
Type:
Grant
Filed:
September 23, 1999
Date of Patent:
April 24, 2001
Assignee:
Kyowa Hakko Kogyo Co., Ltd.
Inventors:
Hiroshi Tsumuki, Junichi Shimada, Hironori Imma, Akiko Nakamura, Hiromi Nonaka, Shizuo Shiozaki, Shunji Ichikawa, Tomoyuki Kanda, Yoshihisa Kuwana, Michio Ichimura, Fumio Suzuki