Abstract: A gas detection method includes a first process, a second process, and a third process. The first to third process include changing routes to be followed by gases into first to third routes, respectively. The first route follows a first passage, a sensor chamber, and a second passage in this order. The second route follows a sample gas supply path, which bypasses a filter unit, and the sensor chamber in this order and allows the gas to be exhausted without letting the gas pass through the filter unit while flowing from the sensor chamber. The third route follows the first passage and the sensor chamber in this order and allows the gas to be exhausted without letting the gas pass through the filter unit while flowing from the sensor chamber.

Abstract: A concentration device that concentrates a solution containing a biological substance includes: a first chamber into which the solution is to be introduced; a second chamber to be filled with a drawing agent; and a film that separates a space of the first chamber and a space of the second chamber. The film has a first region and a second region. The first region is semipermeable in that the first region is permeable to a solvent of the solution but impermeable to the biological substance and the drawing agent. The second region is impermeable to the solution, the biological substance, and the drawing agent. When the solution is introduced into the first chamber, the film is positioned to incline with respect to a surface of the solution. The second region is positioned below the first region with respect to the surface of the solution.

Abstract: A concentration device that concentrates a solution containing a biological substance includes: a first chamber into which the solution is to be introduced; a second chamber to be filled with a drawing agent; and a film that separates a space of the first chamber and a space of the second chamber. The film has a first region and a second region. The first region is semipermeable in that the first region is permeable to a solvent of the solution but impermeable to the biological substance and the drawing agent. The second region is impermeable to the solution, the biological substance, and the drawing agent. When the solution is introduced into the first chamber, the film is positioned to incline with respect to a surface of the solution. The second region is positioned below the first region with respect to the surface of the solution.

Abstract: An electrochemical measuring method uses an electrochemical measuring device in which a measuring liquid is filled into a well. The electrochemical measuring method includes: a step of applying a measuring voltage to a working electrode and measuring a value of a first current flowing in the working electrode; a step of applying a non-measuring voltage to the working electrode; a step of introducing the biological sample into a container; and a step of applying the measuring voltage to the working electrode and measuring a value of a second current flowing in the working electrode.

Abstract: A state of a biological sample is measured by the following method. An electrochemical measuring device including a working electrode and filled with a measuring liquid contacting the working electrode is prepared. A biological sample is put into the measuring liquid. A measuring potential is applied to the working electrode to measure a current value flowing through the working electrode. An oxidation potential is applied to the working electrode to oxidize a surface of the working electrode. This method allows an ambient state of the biological sample to be measured stably.

Abstract: An electrochemical measurement device includes a chip, a working electrode, a first connection portion, a substrate, a second connection portion, a third connection portion, and an upper plate. The working electrode is disposed on the upper surface of the chip. The first connection portion is disposed on the upper surface of the chip, and is electrically connected to the working electrode. The second connection portion is disposed on the upper surface of the substrate. The third connection portion is disposed on the substrate, is electrically connected to the second connection portion, and is to be electrically connected to an external apparatus. The upper plate is disposed on the upper surfaces of the substrate and chip. The upper plate is provided with a first through hole through which the working electrode is exposed.

Abstract: An electrochemical measurement device is configured to measure an activity of a biological sample with a measuring liquid having conductivity. The device includes a plate having first and second wells provided therein, a measuring electrode disposed inside the first well, and a first placement portion provided configured to have the biological sample placed thereon. The first and second wells are provided in an upper surface at positions different from each other. The plate includes a wall separating a bottom surface of the first well from a bottom surface of the second well. The measuring electrode is provided on the bottom surface of the first well around the first placement portion. The second well is configured to have a counter electrode disposed therein. The first and second wells are configured to contain the measuring liquid therein. A portion of the measuring liquid contained in the first well is electrically connected to a portion of the measuring liquid contained in the second well.

Abstract: An electrochemical measuring method uses an electrochemical measuring device in which a measuring liquid is filled into a well. The electrochemical measuring method includes: a step of applying a measuring voltage to a working electrode and measuring a value of a first current flowing in the working electrode; a step of applying a non-measuring voltage to the working electrode; a step of introducing the biological sample into a container; and a step of applying the measuring voltage to the working electrode and measuring a value of a second current flowing in the working electrode.

Abstract: An electrochemical measurement device includes a chip, a working electrode, a first connection portion, a substrate, a second connection portion, a third connection portion, and an upper plate. The working electrode is disposed on the upper surface of the chip. The first connection portion is disposed on the upper surface of the chip, and is electrically connected to the working electrode. The second connection portion is disposed on the upper surface of the substrate. The third connection portion is disposed on the substrate, is electrically connected to the second connection portion, and is to be electrically connected to an external apparatus. The upper plate is disposed on the upper surfaces of the substrate and chip. The upper plate is provided with a first through hole through which the working electrode is exposed.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A flow channel structure includes a substrate having a flow channel formed therein, and plural fibrous bristles extending from the inner wall of the flow channel. The flow channel is configured to allow a solution to flow through the flow channel. The inner wall of the flow channel is made of silicon. The flow channel is configured to allow a solution to flow through the flow channel. This flow channel structure can homogenize the solution inside the flow channel.

Abstract: A silicon structure of the present invention is provided with a silicon substrate (1) to become a base, and a plurality of fibrous projections (2) made of silicon dioxide and directly joined to a silicon-made surface (1a) of the silicon substrate (1). By arbitrarily constructing an area where these fibrous projections (2) are formed in a predetermined area, it is possible to render the area to have at least either hydrophilicity or water retentivity, so as to provide a silicon structure useful for a variety of devices.

Abstract: A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced.

Abstract: A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

Abstract: A sensor includes a diaphragm having a through-hole (1), and includes a frame supporting a diaphragm and having a cavity. Kerfs are formed in a frame so as to extend from an end surface of the frame, and the wall surfaces of the kerfs are made hydrophilic. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and efficiently remove the remaining bubbles. As a result, the bubbles adhering to the vicinity of the through-hole can be removed, and the measuring reliability of the sensor can be improved.

Abstract: A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.