Abstract: [Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. [Means for resolution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that heterocyclic compounds represented by the formula (I) have an excellent degradation-inducing action on a G12D mutant KRAS protein and/or a G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The heterocyclic compound or a salt thereof of the present invention can be used as a therapeutic agent for pancreatic cancer.

Abstract: A light emission device (1) includes a light emitting element (3) having a light emission surface (3A), a first light controller (41) that is formed on the light emission surface (3A) and controls at least one of a wavelength of light, a diffusion of light, or a direction of light, a covering part (5) that is formed on an opposite side to the light emission surface (3A) of the first light controller (41) and covers and protects the first light controller (41), and a first light shielding part (6) that is formed on a side surface of the covering part (5) and shields light.

Abstract: Provided are a conveying device and a conveying method capable of improving the position detection accuracy of the holder as compared with the related art. A conveying device 100 includes a coil 107 including a core 105 and a winding 106, a drive unit 108 that supplies a current to the winding 106, a current detection unit 109 that detects the value of the current flowing through the winding 106, and a control unit 110 that calculates the position of a holder 102, in which the control unit 110 calculates the position of the holder 102 based on the current value detected by the current detection unit 109 and the calibration curve obtained in advance, and changes the calibration curve used depending on how the drive voltage is applied by the drive unit 108.

Abstract: An optical sensor includes two light emitters with the same or substantially the same temperature dependence of luminous intensity of light. A reflector reflects and diffuses light emitted by the light emitters such that a portion of the reflected light is incident on a light receiver. An elastic support supports the reflector, and deforms and changes a relative position of the reflector and the light emitters and the light receiver. A processor calculates a physical quantity depending on an amount of deformation of the elastic support based a ratio between two amounts of light received by the light receiver when respective light emitters emit light at different timings. The light emitters and the light receiver are fixed relative to each other, and a distance from one of the light emitters to the light receiver is different from a distance from another of the light emitters to the light receiver.

Abstract: The present invention enables a simple structure to provide an easy adjustment of damping torque to be caused by applied rotation. The rotary damper (1) is intend to limit movement of viscous fluid filled in a circular cylindrical chamber (111), thereby generating a damping torque in response to an applied rotational force. The lid (15) is the screw-on type capable of being screwed into the casing (11), and thus adjusting a clearance gap G1 between the lid (15) and each partition (115) by way of changing the screwing amount of the lid (15) into the casing (11) allows amount of viscous fluid moving through the clearance gap G1 to be adjusted, thereby resulting in adjustment of a damping torque to be caused by rotation. In addition, each axial force generation member (17) includes a plastically or elastically deformable element and is located between the lid (15) and the corresponding partition (115) to apply a reaction force to the lid (15).

Abstract: The purpose of the present invention is to provide a modified activin A. The present invention provides activin A comprising a modified proregion.

Abstract: A method of manufacturing a cobalt-nickel-containing solution including: preparing a crude nickel hydroxide and/or a crude cobalt hydroxide as a starting material, the crude nickel or cobalt hydroxide containing cobalt and nickel and elements except the cobalt and nickel as impurities, the crude nickel hydroxide containing the nickel more than the cobalt, and the crude cobalt hydroxide containing the cobalt more than the nickel; a water-washing process for obtaining a post-water-washing crude hydroxide from the starting material; a leaching process for obtaining a post-leaching solution from the post-water-washing crude hydroxide; a neutralization process of subjecting the post-leaching solution to neutralization and solid-liquid-separation to remove the impurities as a post-neutralization residue containing one or more of iron, silicon, aluminum, and chromium, thereby obtaining a post-neutralization solution; and an extraction process of subjecting the post-neutralization solution to solvent extraction to ob

Abstract: A money depositing and dispensing machine 1 includes: a storage compartment 100 provided with a first front opening 101; a stowage compartment 200 disposed on a lower side of the storage compartment 100; a storage portion 12 stored in the storage compartment 100 and storing paper sheets; and a conveying unit 13 stored in the storage compartment 100 and for conveying the paper sheets stored in the storage portion 12 to the stowage compartment 200. The conveying unit 13 is configured to be slidable in a direction of the first front opening 101 provided in the storage compartment 100. The stowage compartment 200 stows the paper sheets conveyed by the conveying unit 13.

Abstract: A fermented milk for improving autonomic nervous function containing at least one lactic acid bacterial species of the genus Lactobacillus and its metabolite. The lactic acid bacterial species of the genus Lactobacillus is selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus. The lactic acid bacterial strain of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).

Abstract: An estimation system generates, from a value of a time series of an estimation object in a past period, a plurality of patterns of a transition of a value of the estimation object. Based on the plurality of generated patterns and a value of a time series of a factor in the past period, the estimation system specifies a dependency relationship between a transition pattern and a value of the factor and a transition pattern at a past (or future) time point and identifies a model in accordance with the specified dependency relationship. By inputting a value of a time series of the factor in a future period to the estimation model, the estimation system specifies a time series of a value in the future period of the estimation object using at least one transition pattern.

Abstract: An object of the present disclosure is to provide an optical switch and an optical switch system capable of achieving optical path switching with less power. In order to achieve the above object, an optical switch according to the present disclosure includes a plate-shaped cladding provided with a trench in a thickness direction, opposing lenses exposed to the trench, two optical waveguides coaxially arranged inside the cladding, respective one ends of the optical waveguides being exposed to a surface of the cladding and respective other ends of the optical waveguides opposing each other in the trench via the opposing lenses, a movable transparent body that transmits light of the opposing lenses when the transparent body is sandwiched by the opposing lenses in the trench, and a movable double-sided mirror that reflects light incident from the opposing lenses in a direction opposite to an incident direction when the double-sided mirror is sandwiched between the opposing lenses in the trench.

Abstract: The present disclosure is an optical line switching node device N which includes an optical switch part 2 which performs optical path switching between communication optical fibers F-0, F-1; a communication optical signal extraction part 5-0, 5-1 which extracts some of communication optical signals from one or both of the communication optical fibers F-0, F-1 and photoelectrically converts the extracted some of the communication optical signals; and a communication optical signal storage part 6 which stores some of communication optical signals photoelectrically converted in the communication optical signal extraction part 5-1, 5-1 and uses the stored energy to drive the optical switch part 2.

Abstract: Provided are a program and the like, in which it is possible to display a globe in a photographed image and three-dimensionally display a cloud at the corresponding position. A program according to one aspect causes a computer to execute processing of acquiring an altitude of a cloud at each position, and displaying, when a globe of a reality space is held up, a globe of a first virtual space, in response to a movement of the globe of the reality space, while three-dimensionally displaying a cloud according to a specified altitude at a corresponding position on the first virtual space. Accordingly, it is possible to display the globe in the photographed image and three-dimensionally display the cloud at the corresponding position.

Abstract: Provided is a charged particle beam apparatus capable of realizing a highly reliable insulating structure. This charged particle beam apparatus emits a charged particle beam from a charged particle beam emission device onto a sample, detects charged particles generated from the sample, and creates a sample image or processes the sample. The charged particle beam emission device is provided with a charged particle source and a shield arranged in an interior of a metal housing that is filled with an insulating gas, and an acceleration electrode arranged below the charged particle source, power being supplied to the acceleration electrode via the shield.

Abstract: In a vehicle seat, a side frame of a seat back frame has a front wall that is formed so as to be bent inward continuously from a front edge of a plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching an upper frame, and a rear wall that is formed so as to be bent inward continuously from a rear edge of the plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching the upper frame, and an inner edge of the front wall has a projecting piece that spreads to the inside from a virtual outline corresponding to a shape of the upper frame and is superimposed on the front wall of the upper frame from the rear. This provides a vehicle seat that can contribute to improvement of the work efficiency when assembling a seat back frame.

Abstract: In a vehicle seat, a side frame of a seat back frame has a front wall that is formed so as to be bent inward continuously from a front edge of a plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching an upper frame, and a rear wall that is formed so as to be bent inward continuously from a rear edge of the plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching the upper frame, and an inner edge of the front wall has a projecting piece that spreads to the inside from a virtual outline corresponding to a shape of the upper frame and is superimposed on the front wall of the upper frame from the rear. This provides a vehicle seat that can contribute to improvement of the work efficiency when assembling a seat back frame.

Abstract: In a vehicle seat, a side frame of a seat back frame has a front wall that is formed so as to be bent inward continuously from a front edge of a plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching an upper frame, and a rear wall that is formed so as to be bent inward continuously from a rear edge of the plate-shaped portion and forms a curved region extending vertically from around the rotating shaft and reaching the upper frame, and an inner edge of the front wall has a projecting piece that spreads to the inside from a virtual outline corresponding to a shape of the upper frame and is superimposed on the front wall of the upper frame from the rear. This provides a vehicle seat that can contribute to improvement of the work efficiency when assembling a seat back frame.

Abstract: An imaging method is provided that includes: taking an image of an object to generate an image signal of the object; generating a taken image of the object on a basis of the image signal; detecting motion information of the object on the basis of the image signal; taking an image of the object on a basis of the motion information multiple times so as to differentiate an exposure amount thereof; and generating an HDR synthetic image of the object on the basis of a plurality of image signals whose exposure amounts are different from each other.

Abstract: Provided is a preprocessing device that carries out a dispensing process for aspirating a liquid sample accommodated in a sample container, and subsequently discharging and dispensing the sample into another sample container, the preprocessing device comprising: a dispensing nozzle; a dispensing nozzle tip detachably provided to the distal end of the dispensing nozzle; a disposal box in which the dispensing nozzle tip is disposed of after having been removed from the dispensing nozzle; and a cutting mechanism for cutting a dispensing nozzle tip inserted into a removal part, which removes the dispensing nozzle tip from the dispensing nozzle, from the longitudinal-direction side. This makes it possible to improve accommodation efficiency while suppressing accumulation of disposed-of dispensing nozzle tips.

Abstract: A holding device including a ceramic member formed of a sintered ceramic material containing aluminum nitride as a main component, a heating resistor element formed of a metal and disposed in the ceramic member, an electrically conductive electricity supply connection member in contact with the heating resistor element, and an electrically conductive electricity supply terminal electrically connected to the electricity supply connection member. The holding device holds an object on the surface of the ceramic member. In the holding device, at least a portion of the surface of the electricity supply connection member, excluding its contact surface for contact with the heating resistor element and its connection surface for connection with the electricity supply terminal, is covered with a coat layer formed of a nitride containing at least one of Al, Ti, Zr, V, Ta, and Nb. Also disclosed is a method of manufacturing the holding device.