Patents by Inventor Hiroshi Yagiuchi

Hiroshi Yagiuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing .alpha.-aspartyl-phenylalanine ester
    Patent number: 4730076
    Abstract: The present invention relates to a process for producing .alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR1## wherein R' represents an alkyl group having 1 to 4 carbon atoms, by reducing an N-protected-N-hydroxymethyl-.alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR2## wherein R represents an organic mioety which can be substituted reductively by hydrogen, and R' is as defined above, with hydrogen gas or formic acid, in the presence of a reduction catalyst and an aromatic primary amine. According to the present invention, there can be obtained a high purity .alpha.-aspartyl-phenylalanine ester with a high yield.
    Type: Grant
    Filed: December 16, 1986
    Date of Patent: March 8, 1988
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Tadashi Fujii, Hiroshi Yagiuchi, Akikazu Mitsunobu, Shigeru Aoki, Makoto Tsuda