Patents by Inventor Hiroshi Yasumatsu

Hiroshi Yasumatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having serotonin 5-ht17 receptor antagonist activity and muscarinic m4 receptor agonist activity and their use in the treatment of psychotic disorders
    Publication number: 20060199978
    Abstract: The present invention relates to novel treatments for schizophrenia, based on the concept of identifying agents capable of selectively binding to the serotonin 5-HT7 and muscarinic M4 receptors and the use of such compounds in treating schizophrenia. The present invention also relates to novel amidine compounds for treating schizophrenia, a method of manufacturing such compounds, pharmaceutical formulations comprising said compounds, as well as medical uses and methods of treatment using said compounds.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 7, 2006
    Inventors: Dimitrios Lizos, Clare McKerchar, John Murphy, Yasuyuki Shiigi, Colin Suckling, Hiroshi Yasumatsu, Shen-ze Zhou, Judith Pratt, Brian Morris
  • Condensed thiophene compounds and pharmaceutical use thereof
    Patent number: 6455521
    Abstract: A condensed thiophene compound of the formula (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: September 24, 2002
    Assignee: Mitsubishi Pharma Corporation
    Inventors: Koji Seio, Hiroshi Tanaka, Toshiyuki Kohara, Kenji Hashimoto, Masatake Fujimura, Hideki Horiuchi, Hiroshi Yasumatsu, Koreichi Kimura
  • Condensed thiophene compounds and pharmaceutical use thereof
    Publication number: 20020042411
    Abstract: A condensed thiophene compound of the formula (I) 1
    Type: Application
    Filed: April 19, 2001
    Publication date: April 11, 2002
    Inventors: Koji Seio, Hiroshi Tanaka, Toshiyuki Kohara, Kenji Hashimoto, Masatake Fujimura, Hideki Horiuchi, Hiroshi Yasumatsu, Koreichi Kimura
  • Fused thiophene compounds and medicinal use thereof
    Patent number: 6271225
    Abstract: A condensed thiophene compound of the formula (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: August 7, 2001
    Assignee: Welfide Corporation
    Inventors: Koji Seio, Hiroshi Tanaka, Toshiyuki Kohara, Kenji Hashimoto, Masatake Fujimura, Hideki Horiuchi, Hiroshi Yasumatsu, Koreichi Kimura
  • Method for prophylaxis and treatment of irritable bowel syndrome
    Patent number: 5965557
    Abstract: A method for the prophylaxis and treatment of irritable bowel syndrome, which comprises administering a pharmaceutically effective amount of at least one compound selected from the group consisting of (.+-.)-2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino [5,4-c]pyridazin-3(2H)-one 7-oxide, optical isomers thereof and 2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7,7-dioxide to a subject in need of such prophylaxis or treatment.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: October 12, 1999
    Assignee: Yoshitomi Pharmaceuticals Industries, Ltd.
    Inventors: Kiyoshi Asano, Shigemi Kino, Hiroshi Yasumatsu