Patents by Inventor Hiroshige Tsuzuki

Hiroshige Tsuzuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6919375
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: July 19, 2005
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Wantanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • MMP-12 inhibitors
    Patent number: 6897237
    Abstract: A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is —C?C— and the like; R6 is optionally substituted naphtyl and the like its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: May 24, 2005
    Assignee: Shionogi & Co. Ltd.
    Inventors: Yozo Hori, Fumihiko Watanabe, Hiroshige Tsuzuki, Shingo Furue, Yoshinori Tamura
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6881727
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 19, 2005
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Watanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6838483
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: January 4, 2005
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Wantanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Publication number: 20030225043
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Application
    Filed: November 8, 2002
    Publication date: December 4, 2003
    Applicant: Shionogi & Co., Ltd.
    Inventors: Fumihiko Watanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Mmp-12 inhibitors
    Publication number: 20030158155
    Abstract: A compound of the formula (1): 1
    Type: Application
    Filed: October 15, 2002
    Publication date: August 21, 2003
    Inventors: Yozo Hori, Fumihiko Watanabe, Hiroshige Tsuzuki, Shingo Furue, Yoshinori Tamura
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Publication number: 20030139379
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Application
    Filed: July 3, 2002
    Publication date: July 24, 2003
    Applicant: Shionogi & Co., Ltd.
    Inventors: Fumihiko Watanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6441021
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: August 27, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Wantanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6235768
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: May 22, 2001
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Wantanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6207698
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: March 27, 2001
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Wantanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
    Patent number: 6150394
    Abstract: Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: November 21, 2000
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Watanabe, Hiroshige Tsuzuki, Mitsuaki Ohtani
  • Protease from Streptomyces fradiae
    Patent number: 5665586
    Abstract: According to the present invention, a novel protease derived from Streptomyces fradiae for cleaving the C-terminal of a glutamic acid residue in an amino acid sequence of a polypeptide and a production method for this protease from Streptomyces fradiae are provided, and the characteristics of this protease are made clear. Further, DNA sequences for encoding this protease and a prepropeptide are also made clear. The protease specific to glutamic acid can be used for a variety of purposes including analysis of a protein and cleavage of a peptide chain at a desired site in a fusion protein.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: September 9, 1997
    Assignee: Shionogi & Co., Ltd.
    Inventors: Etsuo Nakamura, Hiroshige Tsuzuki, Kengo Kitadokoro, Masaru Shin, Hiroshi Teraoka
  • Protease
    Patent number: 5459064
    Abstract: A novel protease derived from Bacillus licheniformis is provided. The protease cleaves the peptide bonds at the carboxyl termini of glutamic acid residues in polypeptides. The protease contains an amino acid sequence from serine in the +1 position to glutamine in the +222 position of SEQ ID NO: 1.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: October 17, 1995
    Assignee: Shionogi & Co., Ltd.
    Inventors: Hiroshi Teraoka, Mikio Tamaki, Etsuo Nakamura, Masaru Shin, Nobuo Yoshida, Hiroshige Tsuzuki, Takashi Fujiwara, Koichi Matsumoto
  • Semi-synthesis of human insulin
    Patent number: 4511505
    Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.
    Type: Grant
    Filed: June 3, 1983
    Date of Patent: April 16, 1985
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kazuyuki Morihara, Tatsushi Oka, Hiroshige Tsuzuki
  • Semi-synthesis of human insulin
    Patent number: 4400465
    Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.
    Type: Grant
    Filed: December 31, 1981
    Date of Patent: August 23, 1983
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kazuyuki Morihara, Tatsushi Oka, Hiroshige Tsuzuki
  • Semi-synthesis of human insulin
    Patent number: 4320196
    Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.
    Type: Grant
    Filed: April 9, 1980
    Date of Patent: March 16, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kazuyuki Morihara, Tatsushi Oka, Hiroshige Tsuzuki