Abstract: A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is disclosed. The polypeptide has a molecular weight of 16.+-.1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25.+-.1 Kd, as determined by SDS-electrophoresis in the absence of mercaptoethanol.

Abstract: Disclosed is a gel of microbially-produced cellulose, characterized in that the microbially-produced cellulose is modified by (1) physically or chemically bonding an animal cell adhesive protein to the cellulose, and/or (2) substituting hydrogen atoms of at least parts of hydroxyl groups of the cellulose with a positively or negatively charged organic group. This gel is valuable as a carrier for mass culture of animal cells or as a medical vulnerary cover.

Abstract: Pharmaceutical compositions containing the polypeptides BUF-3, BUF-4 and BUF-5 have hypoglycemic activity. BUF-3 is a homodimer of monomer A shown in FIG. 1. The monomer has a molecular weight of 16.+-.1 kd. BUF-4 is a heterodimer of monomer A and monomer B (FIG. 2). These products can be produced by cell culture of malignant leukemia cells or by recombinant DNA engineering.

Abstract: A cleavage promoting agent comprising as an effective ingredient at least one of the polypeptides BUF-3, BUF-4 and BUF-5 is useful for the treatment of fertilized or unfertilized ova in order to promote cell division and improve reproduction efficiency.

Abstract: The polypeptides BUF-4 and BUF-5 may be used to treat osteoporosis, cancer, and anemia, and pharmaceutical compositions containing BUF-4 and/or BUF-5 are disclosed.

Abstract: An antimycotic agent having a high degree of antimicrobial activity towards Eumycetes and with a level of toxicity lower than that of heptaene antibiotic V-28-3 is disclosed. This compound is a methyl ester derivative of heptaene antibiotic V-28-3.

Abstract: This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof.

Abstract: This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.

Abstract: A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.

Abstract: Mycophenolic acid is produced by aerobically culturing in a culture medium a mutant of the genus Penicillium capable of producing mycophenolic acid, said mutant being resistant to clofibrat, and recovering the mycophenolic acid which accumulates in the culture medium.