Patents by Inventor Hirotaka Matsubara

Hirotaka Matsubara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240124912
    Abstract: This invention provides a novel protein deamidating enzyme.
    Type: Application
    Filed: February 3, 2022
    Publication date: April 18, 2024
    Inventors: Hirotaka MATSUBARA, Keita HIURA
  • Publication number: 20230323423
    Abstract: The present invention addresses the problem of providing a new means capable of modifying a protein material. According to the present invention, a protein material can be modified in property by causing a peptidylprolyl isomerase, or a peptidylprolyl isomerase and a protein modification enzyme to act on the protein material.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 12, 2023
    Inventors: Hirotaka MATSUBARA, Kiyota SAKAI
  • Publication number: 20210388406
    Abstract: A maltotriose-generating amylase has an amino acid sequence of any one three polypeptides. One or more amino acids can be substituted, added, inserted, or deleted, such that the polypeptides have at least 70% sequence identity with the amino acid sequences of the polypeptides. The polypeptides are encoded by DNA, which can be included in recombinant vectors. Transformants can be obtained by transforming a host with the DNA.
    Type: Application
    Filed: October 28, 2019
    Publication date: December 16, 2021
    Inventors: Atsushi ONO, Hirotaka MATSUBARA, Toru KATASE
  • Patent number: 9689010
    Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: June 27, 2017
    Assignees: AMANO ENZYME USA, LTD., AMANO ENZYME, INC.
    Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
  • Patent number: 9498520
    Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: November 22, 2016
    Assignees: AMANO ENZYME INC., AMANO ENZYME USA CO. LTD.
    Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
  • Publication number: 20160024544
    Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.
    Type: Application
    Filed: July 8, 2015
    Publication date: January 28, 2016
    Applicants: Amano Enzyme USA., Ltd., Amano Enzyme, Inc.
    Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
  • Patent number: 9109243
    Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: August 18, 2015
    Assignees: AMANO ENZYME USA, LTD., AMANO ENZYME, INC.
    Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
  • Publication number: 20150182607
    Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 2, 2015
    Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
  • Patent number: 9011842
    Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: April 21, 2015
    Assignees: Amano Enzyme Inc., Amano Enzyme USA Co., Ltd.
    Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
  • Publication number: 20140219982
    Abstract: The present invention is intended to provide a means for efficiently degrades exogenous opioid peptides. Provided is an exogenous opioid peptide-degrading enzyme preparation which contains one or more components selected from the group consisting of enzyme preparations from Penicillium citrinum, Aspergillus oryzae, and Aspergilius melleus, and exhibits a degradation activity for a wheat gluten-derived opioid peptide and a casein-derived opioid peptide.
    Type: Application
    Filed: August 31, 2012
    Publication date: August 7, 2014
    Applicant: AMANO ENZYME INC.
    Inventors: Hirotaka Matsubara, Hiroki Ido, Satoshi Koikeda
  • Patent number: 8735131
    Abstract: An object is to provide a novel method for improving an enzyme capable of deamidating a protein. A mutant protein deamidase is designed by the following steps: (A) identifying one or more amino acid in an amino acid sequence for a protein deamidase which corresponds to the amino acid at position 35, 38 to 43, 45, 46, 49, 79 to 84, 103 to 106, 117, 142, 143, 146, 166, or 185 in the amino acid sequence set forth in SEQ ID NO: 2; and (B) constructing a mutant amino acid sequence of the protein deamidase by substituting the one or more amino acid identified in step (A) with another amino acid or other amino acids or by deleting the one or more amino acid identified in step (A).
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: May 27, 2014
    Assignee: Amano Enzyme Inc.
    Inventors: Ryota Hashizume, Bunzo Mikami, Hirotaka Matsubara, Akiko Matsunaga, Shotaro Yamaguchi
  • Patent number: 8704154
    Abstract: A measuring machine includes a non-contact probe that detects a step gauge without contact. The non-contact probe includes an emitting element that radiates light, a light receiving element that receives the light radiated from the emitting element, and an optical filter that covers an optical path to the light receiving element. The optical filter includes a transmission band in which the light radiated from the emitting element is transmitted and a blocking band in which light to which the light receiving element is sensitive is blocked.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: April 22, 2014
    Assignee: Mitutoyo Corporation
    Inventor: Hirotaka Matsubara
  • Publication number: 20130034531
    Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
    Type: Application
    Filed: February 2, 2011
    Publication date: February 7, 2013
    Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
  • Publication number: 20110200574
    Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
    Type: Application
    Filed: February 2, 2011
    Publication date: August 18, 2011
    Inventors: James F. Jolly, Hiroki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
  • Publication number: 20110165605
    Abstract: An object is to provide a novel method of improving an enzyme capable of deamidating a protein.
    Type: Application
    Filed: August 12, 2009
    Publication date: July 7, 2011
    Applicant: Amano Enzyme Inc.
    Inventors: Ryota Hashizume, Bunzo Mikami, Hirotaka Matsubara, Akiko Matsunaga, Shotaro Yamaguchi
  • Publication number: 20110114828
    Abstract: A measuring machine includes a non-contact probe that detects a step gauge without contact. The non-contact probe includes an emitting element that radiates light, a light receiving element that receives the light radiated from the emitting element, and an optical filter that covers an optical path to the light receiving element. The optical filter includes a transmission band in which the light radiated from the emitting element is transmitted and a blocking band in which light to which the light receiving element is sensitive is blocked.
    Type: Application
    Filed: October 18, 2010
    Publication date: May 19, 2011
    Applicant: MITUTOYO CORPORATION
    Inventor: Hirotaka MATSUBARA
  • Publication number: 20100063001
    Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.
    Type: Application
    Filed: June 3, 2009
    Publication date: March 11, 2010
    Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
  • Patent number: 6857762
    Abstract: A plurality of light emitting elements comprise a number of groups having light emitting colors different from each other. The light emitting element groups are arranged in ring shapes about an optical axis of an optical system in a plane or planes substantially orthogonal to the optical axis. A combining unit combines radiation light beams of different light emitting colors to generate illumination light having a given hue. The combining unit is provided downstream of the light emitting elements along a light emitting direction. A focusing unit focuses the illumination light in the direction toward the optical axis and is provided downstream of the combining unit. Accordingly, it is possible to direct illumination light having uniform and non-irregular hue, the hue corresponding to a surface color of an object to be measured, to the object to be measured.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: February 22, 2005
    Assignee: Mitutoyo Corporation
    Inventors: Seiji Shimokawa, Tatsuya Nagahama, Kuniaki Obata, Hirotaka Matsubara
  • Publication number: 20030231494
    Abstract: A plurality of light emitting elements comprise a number of groups having light emitting colors different from each other. The light emitting element groups are arranged in ring shapes about an optical axis of an optical system in a plane or planes substantially orthogonal to the optical axis. A combining unit combines radiation light beams of different light emitting colors to generate illumination light having a given hue. The combining unit is provided downstream of the light emitting elements along a light emitting direction. A focusing unit focuses the illumination light in the direction toward the optical axis and is provided downstream of the combining unit. Accordingly, it is possible to direct illumination light having uniform and non-irregular hue, the hue corresponding to a surface color of an object to be measured, to the object to be measured.
    Type: Application
    Filed: May 13, 2003
    Publication date: December 18, 2003
    Applicant: Mitutoyo Corporation
    Inventors: Seiji Shimokawa, Tatsuya Nagahama, Kuniaki Obata, Hirotaka Matsubara