Patents by Inventor Hirotaka Matsubara
Hirotaka Matsubara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240124912Abstract: This invention provides a novel protein deamidating enzyme.Type: ApplicationFiled: February 3, 2022Publication date: April 18, 2024Inventors: Hirotaka MATSUBARA, Keita HIURA
-
Publication number: 20230323423Abstract: The present invention addresses the problem of providing a new means capable of modifying a protein material. According to the present invention, a protein material can be modified in property by causing a peptidylprolyl isomerase, or a peptidylprolyl isomerase and a protein modification enzyme to act on the protein material.Type: ApplicationFiled: August 24, 2021Publication date: October 12, 2023Inventors: Hirotaka MATSUBARA, Kiyota SAKAI
-
Publication number: 20210388406Abstract: A maltotriose-generating amylase has an amino acid sequence of any one three polypeptides. One or more amino acids can be substituted, added, inserted, or deleted, such that the polypeptides have at least 70% sequence identity with the amino acid sequences of the polypeptides. The polypeptides are encoded by DNA, which can be included in recombinant vectors. Transformants can be obtained by transforming a host with the DNA.Type: ApplicationFiled: October 28, 2019Publication date: December 16, 2021Inventors: Atsushi ONO, Hirotaka MATSUBARA, Toru KATASE
-
Patent number: 9689010Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.Type: GrantFiled: July 8, 2015Date of Patent: June 27, 2017Assignees: AMANO ENZYME USA, LTD., AMANO ENZYME, INC.Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
-
Patent number: 9498520Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.Type: GrantFiled: January 9, 2015Date of Patent: November 22, 2016Assignees: AMANO ENZYME INC., AMANO ENZYME USA CO. LTD.Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
-
Publication number: 20160024544Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.Type: ApplicationFiled: July 8, 2015Publication date: January 28, 2016Applicants: Amano Enzyme USA., Ltd., Amano Enzyme, Inc.Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
-
Patent number: 9109243Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.Type: GrantFiled: June 3, 2009Date of Patent: August 18, 2015Assignees: AMANO ENZYME USA, LTD., AMANO ENZYME, INC.Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
-
Publication number: 20150182607Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.Type: ApplicationFiled: January 9, 2015Publication date: July 2, 2015Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
-
Patent number: 9011842Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.Type: GrantFiled: February 2, 2011Date of Patent: April 21, 2015Assignees: Amano Enzyme Inc., Amano Enzyme USA Co., Ltd.Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
-
Publication number: 20140219982Abstract: The present invention is intended to provide a means for efficiently degrades exogenous opioid peptides. Provided is an exogenous opioid peptide-degrading enzyme preparation which contains one or more components selected from the group consisting of enzyme preparations from Penicillium citrinum, Aspergillus oryzae, and Aspergilius melleus, and exhibits a degradation activity for a wheat gluten-derived opioid peptide and a casein-derived opioid peptide.Type: ApplicationFiled: August 31, 2012Publication date: August 7, 2014Applicant: AMANO ENZYME INC.Inventors: Hirotaka Matsubara, Hiroki Ido, Satoshi Koikeda
-
Patent number: 8735131Abstract: An object is to provide a novel method for improving an enzyme capable of deamidating a protein. A mutant protein deamidase is designed by the following steps: (A) identifying one or more amino acid in an amino acid sequence for a protein deamidase which corresponds to the amino acid at position 35, 38 to 43, 45, 46, 49, 79 to 84, 103 to 106, 117, 142, 143, 146, 166, or 185 in the amino acid sequence set forth in SEQ ID NO: 2; and (B) constructing a mutant amino acid sequence of the protein deamidase by substituting the one or more amino acid identified in step (A) with another amino acid or other amino acids or by deleting the one or more amino acid identified in step (A).Type: GrantFiled: August 12, 2009Date of Patent: May 27, 2014Assignee: Amano Enzyme Inc.Inventors: Ryota Hashizume, Bunzo Mikami, Hirotaka Matsubara, Akiko Matsunaga, Shotaro Yamaguchi
-
Patent number: 8704154Abstract: A measuring machine includes a non-contact probe that detects a step gauge without contact. The non-contact probe includes an emitting element that radiates light, a light receiving element that receives the light radiated from the emitting element, and an optical filter that covers an optical path to the light receiving element. The optical filter includes a transmission band in which the light radiated from the emitting element is transmitted and a blocking band in which light to which the light receiving element is sensitive is blocked.Type: GrantFiled: October 18, 2010Date of Patent: April 22, 2014Assignee: Mitutoyo CorporationInventor: Hirotaka Matsubara
-
Publication number: 20130034531Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.Type: ApplicationFiled: February 2, 2011Publication date: February 7, 2013Inventors: James F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
-
Publication number: 20110200574Abstract: The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.Type: ApplicationFiled: February 2, 2011Publication date: August 18, 2011Inventors: James F. Jolly, Hiroki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
-
Publication number: 20110165605Abstract: An object is to provide a novel method of improving an enzyme capable of deamidating a protein.Type: ApplicationFiled: August 12, 2009Publication date: July 7, 2011Applicant: Amano Enzyme Inc.Inventors: Ryota Hashizume, Bunzo Mikami, Hirotaka Matsubara, Akiko Matsunaga, Shotaro Yamaguchi
-
Publication number: 20110114828Abstract: A measuring machine includes a non-contact probe that detects a step gauge without contact. The non-contact probe includes an emitting element that radiates light, a light receiving element that receives the light radiated from the emitting element, and an optical filter that covers an optical path to the light receiving element. The optical filter includes a transmission band in which the light radiated from the emitting element is transmitted and a blocking band in which light to which the light receiving element is sensitive is blocked.Type: ApplicationFiled: October 18, 2010Publication date: May 19, 2011Applicant: MITUTOYO CORPORATIONInventor: Hirotaka MATSUBARA
-
Publication number: 20100063001Abstract: Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.Type: ApplicationFiled: June 3, 2009Publication date: March 11, 2010Inventors: James F. Jolly, Krzysztof Klimaszewski, Yuuji Nakanishi, Hirotaka Matsubara, Tetsuya Takahashi, Kyouichi Nishio
-
Patent number: 6857762Abstract: A plurality of light emitting elements comprise a number of groups having light emitting colors different from each other. The light emitting element groups are arranged in ring shapes about an optical axis of an optical system in a plane or planes substantially orthogonal to the optical axis. A combining unit combines radiation light beams of different light emitting colors to generate illumination light having a given hue. The combining unit is provided downstream of the light emitting elements along a light emitting direction. A focusing unit focuses the illumination light in the direction toward the optical axis and is provided downstream of the combining unit. Accordingly, it is possible to direct illumination light having uniform and non-irregular hue, the hue corresponding to a surface color of an object to be measured, to the object to be measured.Type: GrantFiled: May 13, 2003Date of Patent: February 22, 2005Assignee: Mitutoyo CorporationInventors: Seiji Shimokawa, Tatsuya Nagahama, Kuniaki Obata, Hirotaka Matsubara
-
Publication number: 20030231494Abstract: A plurality of light emitting elements comprise a number of groups having light emitting colors different from each other. The light emitting element groups are arranged in ring shapes about an optical axis of an optical system in a plane or planes substantially orthogonal to the optical axis. A combining unit combines radiation light beams of different light emitting colors to generate illumination light having a given hue. The combining unit is provided downstream of the light emitting elements along a light emitting direction. A focusing unit focuses the illumination light in the direction toward the optical axis and is provided downstream of the combining unit. Accordingly, it is possible to direct illumination light having uniform and non-irregular hue, the hue corresponding to a surface color of an object to be measured, to the object to be measured.Type: ApplicationFiled: May 13, 2003Publication date: December 18, 2003Applicant: Mitutoyo CorporationInventors: Seiji Shimokawa, Tatsuya Nagahama, Kuniaki Obata, Hirotaka Matsubara