Patents by Inventor Hirotaka Yuki

Hirotaka Yuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of producing recombinant insulin from novel fused proteins
    Patent number: 6841361
    Abstract: This invention relates to a DNA encoding a fusion protein of formula (I) [Y]-[X1]-[B-chain]-[X2]-[Linker]-[X3]-[A-chain]??(I) wherein Y is a leader peptide sequence for the expression and secretion of the protein, comprising at least one amino acid residue; X1 is an amino acid sequence which is cleavable enzymatically or chemically; B-chain is the amino acid sequence of insulin B chain; X2 is an amino acid sequence which is cleavable enzymatically; Linker is a linker sequence comprising at least one amino acid residue; X3 is an amino acid sequence which is cleavable enzymatically; and A- chain is the amino acid sequence of insulin A chain, and to a method for producing insulin using an expression system containing the DNA in high efficiency and high yield.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: January 11, 2005
    Assignee: Itoham Foods Inc.
    Inventors: Shusaku Oka, Seiji Sato, Naohiko Higashikuni, Masaaki Kondo, Toshiyuki Kudo, Shigeaki Watanabe, Yoshihiro Waki, Hirotaka Yuki