Patents by Inventor Hiroto Fujii
Hiroto Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250172227Abstract: A timing at which a compression amount in a radial direction of an annular sealing member becomes maximum during a connection operation between a body portion and a mating portion in a complex connector structure differs between a first connector structure portion which is one of connector structure portions and a second connector structure portion which is another one of the connector structure portions. Alternatively, in the complex connector structure, a body assembling portion of each of body connection portions allows change in a relative position between a front-side divisional part and a rear-side divisional part in a radial direction of the body connection portion and restricts change in a relative position between the front-side divisional part and the rear-side divisional part in an axial direction of the body connection portion.Type: ApplicationFiled: October 29, 2024Publication date: May 29, 2025Inventors: Hiroto FUJII, Shota SUZUKI, Tomokazu SOBAJIMA, Tsukasa NAKAI
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Publication number: 20230250401Abstract: A method for selecting a cell strain in which reduction of a recombinant protein is suppressed, and uses of the selected cell are disclosed. The method for selecting a cell, includes a first step: measuring the expression level of a gene in a cell, the gene being at least one gene selected from genes comprising any one of the base sequences represented by SEQ ID NOS: 1 to 16 or orthologous genes thereof; and a second step: comparing the expression level of the gene measured in the first step with a control value of the expression level of the gene in a control cell, and evaluating the expression level capable of suppressing reduction of a recombinant protein based on a difference therebetween.Type: ApplicationFiled: April 14, 2023Publication date: August 10, 2023Applicant: KYOWA KIRIN CO., LTD.Inventors: Koichi YAMAMOTO, Yuichi MATSUMOTO, Keina YAMAGUCHI, Hiroto FUJII, Toshiyuki SUZAWA
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Publication number: 20190316096Abstract: An object of the present invention is to provide a method for selecting a cell strain in which reduction of a recombinant protein is suppressed. The present invention relates to a method for selecting a cell, comprising a first step: measuring the expression level of a gene in a cell, the gene being at least one gene selected from genes comprising any one of the base sequences represented by SEQ ID NOS: 1 to 16 or orthologous genes thereof; and a second step: comparing the expression level of the gene measured in the first step with a control value of the expression level of the gene in a control cell, and evaluating the expression level capable of suppressing reduction of a recombinant protein based on a difference therebetween.Type: ApplicationFiled: December 27, 2017Publication date: October 17, 2019Applicant: KYOWA HAKKO KIRIN COInventors: Koichi YAMAMOTO, Yuichi MATSUMOTO, Keina YAMAGUCHI, Hiroto FUJII, Toshiyuki SUZAWA
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Patent number: 7730875Abstract: A spool valve is movably provided in a valve sliding space of a valve casing. The spool valve has a through-hole formed in the inside thereof, and a communication port formed in the spool valve is operatively communicated with a fluid port for controlling an opening area of the fluid port by moving within the valve sliding space. Multiple circular oil grooves are formed at an outer peripheral surface of the spool valve, into which high pressure fluid is supplied so that the spool valve can be smoothly moved in the valve sliding space.Type: GrantFiled: September 26, 2005Date of Patent: June 8, 2010Assignee: Denso CorporationInventors: Katsumi Mori, Hiroto Fujii, Nobuhiro Akashi
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Patent number: 7578280Abstract: A fuel injection system for an internal combustion engine is provided which includes a fuel injector equipped with an actuator and a nozzle needle. The actuator works to lift the nozzle needle to inject fuel into an internal combustion engine. A controller controls an operation of the actuator to change an amount of lift of the nozzle needle a given number of times for a target injection duration, thereby ensuring the uniformity of size of atomized particles of the fuel sprayed from the fuel injector.Type: GrantFiled: July 3, 2007Date of Patent: August 25, 2009Assignee: Denso CorporationInventor: Hiroto Fujii
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Patent number: 7552709Abstract: A common rail injection system for internal combustion diesel engines is provided which is designed to correct a limit of width of an ineffective injection command pulse signal which is to be applied to each fuel injector, but causes the injector to produce no spray of fuel in order to minimize a variation in quantity of fuel injected to the engine between the injectors arising from the individual variability or aging of the injectors. The system works to changes the width of a pilot injection command pulse signal to search a value thereof when an engine operation variation such as a change in speed of the engine exceeds or decreases below a threshold at which the injector may be viewed as having sprayed the fuel actually or stopped spraying the fuel actually and determines the limit of width of the ineffective injection command pulse signal using the searched value.Type: GrantFiled: November 1, 2005Date of Patent: June 30, 2009Assignee: Denso CorporationInventor: Hiroto Fujii
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Patent number: 7522987Abstract: An apparatus aims at learning a deviation from a reference injection characteristic of a fuel injector provided for a cylinder of an engine having an output shaft. In the apparatus, a detecting unit is configured to detect a minimum interval between temporally adjacent fuel injection periods in the plurality of fuel injection periods based on a behavior of the output shaft during execution of the plurality of fuel injections. The minimum interval maintains the temporally adjacent fuel injection periods to be non-overlapped with each other. A learning unit is configured to learn the deviation from the reference injection characteristic of the fuel injector based on the detected minimum interval.Type: GrantFiled: July 17, 2007Date of Patent: April 21, 2009Assignee: Denso CorporationInventor: Hiroto Fujii
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Publication number: 20080105767Abstract: A fuel injection apparatus includes a nozzle portion, into which fuel flows. The nozzle portion includes at least one nozzle hole. Fuel is injected through the at least one nozzle hole. Each of the at least one nozzle hole includes a nozzle hole outlet region. A cross-sectional area of the nozzle hole outlet region decreases continuously or stepwise in a direction opposite from a fuel flowing direction.Type: ApplicationFiled: September 6, 2007Publication date: May 8, 2008Applicant: DENSO CORPORATIONInventors: Hiroto Fujii, Yuusuke Ootani
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Patent number: 7363141Abstract: A method is provided to manufacture a fuel injection control system controlling fuel injection in an internal combustion engine with a fuel injection valve. A fuel injection valve is trial-manufactured. Using this valve, correcting amounts for an injection period are calculated at plural adjustment points defined by fuel pressures and injection periods. The adjustment points are divided into actual-measuring points and predicting points, and the correcting amounts at the actual-measuring points are used to calculate predicting expressions to predict correcting amounts at the predicting points and relational expressions to define a relationship among the correcting amounts at the actual-measuring points. When the valve is mass-manufactured, for each mass-manufactured valve, the correcting amounts at the actual-measuring points and the predicting expressions are used to predict correcting amounts at the predicting points, providing the correcting amounts at the actual-measuring and correcting points.Type: GrantFiled: September 11, 2006Date of Patent: April 22, 2008Assignee: Denso CorporationInventor: Hiroto Fujii
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Publication number: 20080017173Abstract: An apparatus aims at learning a deviation from a reference injection characteristic of a fuel injector provided for a cylinder of an engine having an output shaft. In the apparatus, a detecting unit is configured to detect a minimum interval between temporally adjacent fuel injection periods in the plurality of fuel injection periods based on a behavior of the output shaft during execution of the plurality of fuel injections. The minimum interval maintains the temporally adjacent fuel injection periods to be non-overlapped with each other. A learning unit is configured to learn the deviation from the reference injection characteristic of the fuel injector based on the detected minimum interval.Type: ApplicationFiled: July 17, 2007Publication date: January 24, 2008Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Publication number: 20080006243Abstract: A fuel injection system for an internal combustion engine is provided which includes a fuel injector equipped with an actuator and a nozzle needle. The actuator works to lift the nozzle needle to inject fuel into an internal combustion engine. A controller controls an operation of the actuator to change an amount of lift of the nozzle needle a given number of times for a target injection duration, thereby ensuring the uniformity of size of atomized particles of the fuel sprayed from the fuel injector.Type: ApplicationFiled: July 3, 2007Publication date: January 10, 2008Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Patent number: 7305971Abstract: A common rail fuel injection apparatus for an engine is provided which is equipped with a rail pressure sensor working to measure the pressure of fuel in a common rail, fuel injectors, and a controller. When the operation state of the rail pressure sensor monitored to be unusual, the controller changes the value of electricity supplied to an actuator of one of the fuel injectors to induce a change in a preselected operation characteristic of the engine. Upon appearance of such a change, the controller estimates the value of the rail pressure using the changed value of the electricity and a physical property of balance among forces acting on a valve of one of the fuel injectors which has induced the change in operation characteristic of the engine. The estimated value of the rail pressure is used for subsequent injections of the fuel into the engine.Type: GrantFiled: January 19, 2006Date of Patent: December 11, 2007Assignee: Denso CorporationInventor: Hiroto Fujii
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Patent number: 7222608Abstract: An injector has a housing, a command piston, a control chamber, a needle, a nozzle chamber, a fuel inflow passage, a fuel discharge passage and an electric valve. The housing slidably supports the command piston and the needle. The housing and one end face of the command piston enclose the control chamber. The needle is disposed at the other end face side of the command piston. The housing and a leading end portion of the needle enclose the nozzle chamber to accumulate the high-pressure fuel therein. The housing is provided with an injection hole, which is opened and blocked by the needle. The fuel discharge passage opens at a fuel discharge port to the control chamber to discharge the high-pressure fuel out of the control chamber. The fuel discharge port is close to an uppermost position of the command piston.Type: GrantFiled: September 1, 2005Date of Patent: May 29, 2007Assignee: Denso CorporationInventor: Hiroto Fujii
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Publication number: 20070056564Abstract: A method is provided to manufacture a fuel injection control system controlling fuel injection in an internal combustion engine with a fuel injection valve. A fuel injection valve is trial-manufactured. Using this valve, correcting amounts for an injection period are calculated at plural adjustment points defined by fuel pressures and injection periods. The adjustment points are divided into actual-measuring points and predicting points, and the correcting amounts at the actual-measuring points are used to calculate predicting expressions to predict correcting amounts at the predicting points and relational expressions to define a relationship among the correcting amounts at the actual-measuring points. When the valve is mass-manufactured, for each mass-manufactured valve, the correcting amounts at the actual-measuring points and the predicting expressions are used to predict correcting amounts at the predicting points, providing the correcting amounts at the actual-measuring and correcting points.Type: ApplicationFiled: September 11, 2006Publication date: March 15, 2007Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Publication number: 20070028895Abstract: A common rail fuel injection apparatus for an engine is provided which is equipped with a rail pressure sensor working to measure the pressure of fuel in a common rail, fuel injectors, and a controller. When the operation state of the rail pressure sensor monitored to be unusual, the controller changes the value of electricity supplied to an actuator of one of the fuel injectors to induce a change in a preselected operation characteristic of the engine. Upon appearance of such a change, the controller estimates the value of the rail pressure using the changed value of the electricity and a physical property of balance among forces acting on a valve of one of the fuel injectors which has induced the change in operation characteristic of the engine. The estimated value of the rail pressure is used for subsequent injections of the fuel into the engine.Type: ApplicationFiled: January 19, 2006Publication date: February 8, 2007Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Publication number: 20060090733Abstract: A common rail injection system for internal combustion diesel engines is provided which is designed to correct a limit of width of an ineffective injection command pulse signal which is to be applied to each fuel injector, but causes the injector to produce no spray of fuel in order to minimize a variation in quantity of fuel injected to the engine between the injectors arising from the individual variability or aging of the injectors. The system works to changes the width of a pilot injection command pulse signal to search a value thereof when an engine operation variation such as a change in speed of the engine exceeds or decreases below a threshold at which the injector may be viewed as having sprayed the fuel actually or stopped spraying the fuel actually and determines the limit of width of the ineffective injection command pulse signal using the searched value.Type: ApplicationFiled: November 1, 2005Publication date: May 4, 2006Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Publication number: 20060065870Abstract: A spool valve is movably provided in a valve sliding space of a valve casing. The spool valve has a through-hole formed in the inside thereof, and a communication port formed in the spool valve is operatively communicated with a fluid port for controlling an opening area of the fluid port by moving within the valve sliding space. Multiple circular oil grooves are formed at an outer peripheral surface of the spool valve, into which high pressure fluid is supplied so that the spool valve can be smoothly moved in the valve sliding space.Type: ApplicationFiled: September 26, 2005Publication date: March 30, 2006Applicant: Denso CorporationInventors: Katsumi Mori, Hiroto Fujii, Nobuhiro Akashi
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Publication number: 20060060663Abstract: An injector has a housing, a command piston, a control chamber, a needle, a nozzle chamber, a fuel inflow passage, a fuel discharge passage and an electric valve. The housing slidably supports the command piston and the needle. The housing and one end face of the command piston enclose the control chamber. The needle is disposed at the other end face side of the command piston. The housing and a leading end portion of the needle enclose the nozzle chamber to accumulate the high-pressure fuel therein. The housing is provided with an injection hole, which is opened and blocked by the needle. The fuel discharge passage opens at a fuel discharge port to the control chamber to discharge the high-pressure fuel out of the control chamber. The fuel discharge port is close to an uppermost position of the command piston.Type: ApplicationFiled: September 1, 2005Publication date: March 23, 2006Applicant: DENSO CORPORATIONInventor: Hiroto Fujii
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Patent number: 4898705Abstract: A method for producing a synthetic resin union joint, the method including the steps of forming a union nut having a screw portion and a union sleeve of an elastically softenable material, the union sleeve having a union swivel end and a connecting end, heating a length of the union nut at least equal to a thickness dimension of the flange part but not extending to the screw portion so as to elastically soften the length of the union nut, abutting one end of a truncated cone-shaped expansion guide with an end face of the union swivel end, shifting and enlarging the length of the union nut along the expansion guide so as to pass over the union swivel end and so that the union nut passes over the guide, and returning the length of the union nut to its original configuration due to a restoring force of the elastically softenable material so as to be positioned within the union swivel end and the connecting end.Type: GrantFiled: May 16, 1988Date of Patent: February 6, 1990Assignee: Kubotatekko Kabushiki KaishaInventors: Junsuke Kyomen, Masayuki Sakaguchi, Hiroto Fujii