Patents by Inventor Hiroto Furuta

Hiroto Furuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TEST METHOD FOR TYPE-2 DIABETES USING GENE POLYMORPHISM
    Publication number: 20110151456
    Abstract: The present invention relates to a method of testing for genetic susceptibility to type-2 diabetes in a subject that comprises detecting one or more polymorphisms present in the KCNQ1 gene and/or EIF2AK4 gene in a DNA-containing sample collected from the subject. The present invention permit a method of accurately, conveniently, and rapidly testing the genetic susceptibility of subjects to type-2 by targeting determinative genetic factors of genetic susceptibility to type-2 diabetes.
    Type: Application
    Filed: December 15, 2008
    Publication date: June 23, 2011
    Applicants: National Center for Global Health and Medicine, The University of Tokyo, National University Corporation Ehime University
    Inventors: Kazuki Yasuda, Masato Kasuga, Takashi Kadowaki, Hiroto Furuta, Hideichi Makino, Naoko Iwasaki, Yukio Horikawa, Kazuya Yamagata, Yoshitomo Oka
  • Mutations in the diabetes susceptibility genes hepatocyte nuclear factor (HNF) 1 alpha (alpha), HNF-1beta and HNF-4alpha
    Publication number: 20030224355
    Abstract: The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF1&agr; gene, MODY4 locus is the HNF1&bgr; and the MODY1 locus is the HNF4&agr; gene. The invention further relates to the discovery that analysis of mutations in the HNF1&agr;, HNF1&bgr; and HNF4&agr; genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF1&agr;, HNF1&bgr; and HNF4&agr; mutations can cause diabetes.
    Type: Application
    Filed: January 3, 2001
    Publication date: December 4, 2003
    Applicant: ARCH Development Corporation
    Inventors: Graeme I. Bell, Kazuya Yamagata, Naohisha Oda, Pamela J. Kaisaki, Hiroto Furuta, Yukio Horikawa, Stephan Menzel
  • Human Nkx-2.2 polypeptide-encoding nucleotide sequences
    Patent number: 6239258
    Abstract: The present invention features a human Nkx-2.2 polypeptide and nucleotide sequences encoding Nkx-2.2 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In addition, the invention features polynucleotide sequences that hybridize under stringent conditions to SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human Nkx-2.2 polypeptide. The present invention also relates to antibodies that bind specifically to a human Nkx-2.2 polypeptide, and methods for producing human Nkx-2.2 polypeptides.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: May 29, 2001
    Assignees: The Regents of the University of California, Arch Development Corp.
    Inventors: Michael S. German, Graeme I. Bell, Hiroto Furuta, Lori Sussel
  • Mutations in the diabetes susceptibility genes hepatocyte nuclear factor (HNF) 1 alpha (&agr;), HNF1&bgr; and HNF4&agr;
    Patent number: 6187533
    Abstract: The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF1&agr; gene, MODY4 locus is the HNF1&bgr; and the MODY1 locus is the HNF4&agr; gene. The invention further relates to the discovery that analysis of mutations in the HNF1&agr;, HNF1&bgr; and HNF4&agr; genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF1&agr;, HNF1&bgr; and HNF4&agr; mutations can cause diabetes.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: February 13, 2001
    Assignee: Arch Development Corporation
    Inventors: Graeme I. Bell, Kazuya Yamagata, Naohisha Oda, Pamela J. Kaisaki, Hiroto Furuta, Yukio Horikawa, Stephan Menzel