Patents by Inventor Hiroto Onuma

Hiroto Onuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine containing immobilized virus particles
    Patent number: 10881723
    Abstract: The present invention relates to a vaccine containing fixed virus particles, wherein a summed fever response of three rabbits to the fixed virus particles in a pyrogen test is less than 80% based on a summed fever response of three rabbits to original virus particles of the fixed virus particles or corresponding inactivated virus particles.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: January 5, 2021
    Assignee: KM BIOLOGICS CO., LTD.
    Inventors: Hiroto Onuma, Yukari Tsurudome, Kazuyuki Ikeda, Ryo Yamaue, Kazuhiko Kimachi, Motoharu Abe, Akihiro Watanabe, Yuki Ohara
  • Vaccine Containing Virus-Like Particles
    Publication number: 20200093915
    Abstract: The present invention provides a vaccine containing virus-like particles derived from virus particles having an envelope, in which a lipid-component content of the virus-like particles is reduced relative to a lipid-component content of the virus particles.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 26, 2020
    Applicant: KM Biologics Co., Ltd.
    Inventors: Kazuhiko Kimachi, Motoharu Abe, Kazuyuki Ikeda, Hiroto Onuma, Yukari Tsurudome, Daisuke Ikeno, Kiyoto Nishiyama, Tatsufumi Onchi, Yusuke Ooyama, Issay Asano, Ryoichi Kitano
  • Vaccine containing virus-like particles
    Patent number: 10525122
    Abstract: The present invention provides a vaccine containing virus-like particles derived from virus particles having an envelope, in which a lipid-component content of the virus-like particles is reduced relative to a lipid-component content of the virus particles.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 7, 2020
    Assignee: KM Biologics Co., Ltd.
    Inventors: Kazuhiko Kimachi, Motoharu Abe, Kazuyuki Ikeda, Hiroto Onuma, Yukari Tsurudome, Daisuke Ikeno, Kiyoto Nishiyama, Tatsufumi Onchi, Yusuke Ooyama, Issay Asano, Ryoichi Kitano
  • VACCINE CONTAINING IMMOBILIZED VIRUS PARTICLES
    Publication number: 20190000960
    Abstract: The present invention relates to a vaccine containing fixed virus particles, wherein a summed fever response of three rabbits to the fixed virus particles in a pyrogen test is less than 80% based on a summed fever response of three rabbits to original virus particles of the fixed virus particles or corresponding inactivated virus particles.
    Type: Application
    Filed: January 10, 2017
    Publication date: January 3, 2019
    Inventors: Hiroto ONUMA, Yukari TSURUDOME, Kazuyuki IKEDA, Ryo YAMAUE, Kazuhiko KIMACHI, Motoharu ABE, Akihiro WATANABE, Yuki OHARA
  • Vaccine Containing Virus-Like Particles
    Publication number: 20170196965
    Abstract: The present invention provides a vaccine containing virus-like particles derived from virus particles having an envelope, in which a lipid-component content of the virus-like particles is reduced relative to a lipid-component content of the virus particles.
    Type: Application
    Filed: July 15, 2015
    Publication date: July 13, 2017
    Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Kazuhiko KIMACHI, Motoharu ABE, Kazuyuki IKEDA, Hiroto ONUMA, Yukari TSURUDOME, Daisuke IKENO, Kiyoto NISHIYAMA, Tatsufumi ONCHI, Yusuke OOYAMA, Issay ASANO, Ryoichi KITANO
  • Photoreduction method for hemoglobin-vesicle
    Patent number: 6916303
    Abstract: A method and an apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method includes adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: July 12, 2005
    Assignee: Japan Science and Technology Corporation
    Inventors: Eishun Tsuchida, Hiromi Sakai, Hiroto Onuma, Shinji Takeoka
  • Photoreduction method for hemoglobin-visicle
    Publication number: 20020095108
    Abstract: Disclosed is a method and apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method comprises adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.
    Type: Application
    Filed: February 12, 2002
    Publication date: July 18, 2002
    Applicant: Japan Science and Technology Corporation
    Inventors: Eishun Tsuchida, Hiromi Sakai, Hiroto Onuma, Shinji Takeoka