Abstract: A method for estimating an emotional state is executed by a computer and includes acquiring an amount of change of a cerebral blood flow of a user from a reference time, acquiring an amount of change of a heart rate of the user from a reference time, and outputting a signal indicating that the user is in an excited state in a case where the amount of change of the cerebral blood flow is smaller than a first threshold value and the amount of change of the heart rate is larger than a second threshold value.

Abstract: The present disclosure provides a sensor substrate that detects an analyte of a low concentration with high sensitivity and high reliability. The sensor substrate according to the present disclosure a first substrate having first microprotrusions provided on the surface thereof and covered by a metal film, an adhesive film disposed on the surface of the first substrate and having a slit, and a second substrate that is transparent, disposed on the adhesive film, and having a first through hole and a second through hole, wherein each of the first through hole and the second through hole is in communication with the slit, and the first microprotrusions overlap the slit in a plan view.

Abstract: A biological measurement device includes a light emitting device, a sensor, and a processing circuit. The light emitting device irradiates a first region and a second region, which is located on an upper side relative to the first region, of a forehead of a subject with light. The sensor detects first scattering light generated by the light incident on the first region and second scattering light generated by the light incident on the second region and outputs detection signals according to intensities of the first and second scattering light. The processing circuit selects one of the first and second regions as a target region based on the detection signals and/or an image signal indicative of an image including a face of the subject and generates and outputs brain activity data indicative of a state of brain activity of the subject based on the detection signal in the selected target region.

Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.

Abstract: A measurement apparatus includes a light source, a sensor with photoelectric converters, and a processing circuit. The processing circuit executes a detection operation multiple times to acquire multiple detection signals. The detection operation includes: causing the light source to emit a light pulse; and causing the sensor to detect at least part of an internal scattering component of a reflected light pulse, and output a detection signal representing a spatial distribution of intensity of the at least part of the internal scattering component. The reflected light pulse arises from the target portion due to emission of the light pulse. The internal scattering component is a component scattered in an interior of the target portion. The detection signal is included in the multiple detection signals. The processing circuit, based on the multiple detection signals, generates and outputs distribution data representing a spatial distribution of muscle oxygen consumption in the target portion.

Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.

Abstract: The present disclosure provides a sensor substrate capable of detecting a trace amount of an analyte. This sensor substrate according to the present disclosure is a sensor substrate comprising a metal microstructure that generates surface plasmon when irradiated with excitation light. The metal microstructure is composed of a plurality of protrusions disposed in a planar shape. The plurality of the protrusions are disposed in such a manner that imaginary lines V each passing through a center between adjacent protrusions draw a honeycomb shape in a plan view. Each of the plurality of the protrusions has a substantially hexagonal shape in the plan view. A depth in a thickness direction of the sensor substrate of a gap present between the adjacent protrusions is larger than a radius of an imaginary circle inscribed in a hexagon forming the honeycomb shape.

Abstract: A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.

Abstract: A detection method including forming a complex by binding, to a target substance, a first substance immobilized to a metal particle with magnetism and a second substance labeled with a fluorescent material, moving the complex by applying a magnetic field, illuminating the complex during movement with excitation light of a predetermined wavelength, the excitation light causing the fluorescent material to emit fluorescence, the fluorescence being enhanced by localized surface plasmon resonance that is produced by the metal particle, capturing the enhanced fluorescence over time and obtaining two-dimensional images, and detecting the target substance in accordance with a light spot included in each of the two-dimensional images, the metal particle including an inner core made of a magnetic material and an outer shell covering the inner core, the outer shell being made of a nonmagnetic metal material that produces the localized surface plasmon resonance.

Abstract: The present disclosure provides a complex having satisfactory dispersibility and stable luminescence characteristics. A complex of the present disclosure includes: a first substance having a property of specifically binding to a target substance; a quantum dot that contains silicon as a main component and that is negatively charged on a surface; and a linker substance that contains a compound represented by general formula (1) below and that covers the surface of the quantum dot, where the first substance has been immobilized on the surface of the quantum dot through the linker substance: X—L—Si—(R1)(R2)(OR3)??(1) where X is a basic functional group; R1, R2, and R3 are each independently an alkyl group; and L is an alkylene group.

Abstract: The present disclosure provides a sensor substrate that detects an analyte of a low concentration with high sensitivity and high reliability. The sensor substrate according to the present disclosure a first substrate having first microprotrusions provided on the surface thereof and covered by a metal film, an adhesive film disposed on the surface of the first substrate and having a slit, and a second substrate that is transparent, disposed on the adhesive film, and having a first through hole and a second through hole, wherein each of the first through hole and the second through hole is in communication with the slit, and the first microprotrusions overlap the slit in a plan view.

Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.

Abstract: A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.

Abstract: A device control system including a wearable device and a server. The wearable device includes a device that ejects a fragrance material, a biological sensor, and a computer. The computer transmits biological data to the server, receives a first control signal, and causes the device to eject a fragrance material upon receipt of the first control signal. The server includes a computer. The computer receives the biological data, estimates user's emotion from the received biological data, and in a case where it is determined that the user has positive emotion by using a result of the estimation, (i) transmits the first control signal to the wearable device and (ii) transmits, to an aroma device, a second control signal for causing the aroma device to eject a fragrance material at a predetermined timing.

Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.

Abstract: The present disclosure provides a sensor substrate capable of detecting a trace amount of an analyte. This sensor substrate according to the present disclosure is a sensor substrate comprising a metal microstructure that generates surface plasmon when irradiated with excitation light. The metal microstructure is composed of a plurality of protrusions disposed in a planar shape. The plurality of the protrusions are disposed in such a manner that imaginary lines V each passing through a center between adjacent protrusions draw a honeycomb shape in a plan view. Each of the plurality of the protrusions has a substantially hexagonal shape in the plan view. A depth in a thickness direction of the sensor substrate of a gap present between the adjacent protrusions is larger than a radius of an imaginary circle inscribed in a hexagon forming the honeycomb shape.

Abstract: An information processing apparatus includes a communication interface that receives biological data regarding a user, a memory that stores the biological data, and a processor that determines a type of feeling experienced by the user in a certain period using the biological data. The processor estimates an event that has occurred to the user in the certain period, stores, in a database, feeling history information in which the certain period, feeling type information indicating the type of feeling, and event information indicating the estimated event are associated with one another, generates, if the feeling type information indicates a feeling of pleasure, image data using the associated event information, and outputs a notification for displaying the image data to a terminal device used by the user.

Abstract: A device control system including a wearable device and a server. The wearable device includes a device that ejects a fragrance material, a biological sensor, and a computer. The computer transmits biological data to the server, receives a first control signal, and causes the device to eject a fragrance material upon receipt of the first control signal. The server includes a computer. The computer receives the biological data, estimates users emotion from the received biological data, and in a case where it is determined that the user has positive emotion by using a result of the estimation, (i) transmits the first control signal to the wearable device and (ii) transmits, to an aroma device, a second control signal for causing the aroma device to eject a fragrance material at a predetermined timing.

Abstract: An information input/display device including: a sensor detecting contact and outputting contact positions; a display unit displaying video signals each corresponding to one screen; a first drawing unit generating first video signals each corresponding to one screen, when displayed, that includes an image of a drawing of a continuous line formed by the contact positions; a second drawing unit generating second video signals each corresponding to an image of the drawing of the continuous line, the second drawing unit generating images of the drawing of the continuous line at a higher speed than the first drawing unit; and an adding unit adding each of the second video signals to a corresponding one of the first video signals. Images of the drawing of the continuous line generated by at least one of the first drawing unit and the second drawing unit change as time elapses in drawing processing.

Abstract: An ultraviolet irradiation apparatus includes a fluid holder including a bottom portion having an upper surface and a lower surface, the bottom portion holding a fluid on the upper surface with a substantially uniform thickness; and a light-emitting device that substantially uniformly irradiates the fluid held on the upper surface with ultraviolet light.