Patents by Inventor Hirotoshi Hayasawa

Hirotoshi Hayasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8486462
    Abstract: 3-O-?-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: July 16, 2013
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Patent number: 8338403
    Abstract: A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: December 25, 2012
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Publication number: 20100240632
    Abstract: A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Application
    Filed: June 1, 2010
    Publication date: September 23, 2010
    Applicant: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Patent number: 7754704
    Abstract: A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: July 13, 2010
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Patent number: 7674784
    Abstract: A compound having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: March 9, 2010
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Patent number: 7534770
    Abstract: 3-O-?-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: May 19, 2009
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Publication number: 20090075913
    Abstract: 3-O-?-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
    Type: Application
    Filed: July 25, 2008
    Publication date: March 19, 2009
    Applicant: Morinaga Milk Industry Co., Ltd.
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Publication number: 20080044500
    Abstract: 3-O-?-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 21, 2008
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Publication number: 20070196435
    Abstract: A compound having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 23, 2007
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Patent number: 7217524
    Abstract: Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: May 15, 2007
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Shinya Suzu, Hiroaki Hageshita, Kouji Nomaguchi, Muneo Yamada, Hirotoshi Hayasawa
  • Publication number: 20070032463
    Abstract: A compound having a hyperglycemia improving effect and a hemoglobin Alc lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 8, 2007
    Inventors: Ryuuichi Higuchi, Masanori Inagaki, Hirotoshi Hayasawa, Muneo Yamada, Miyuki Tanaka, Eriko Misawa, Noriko Wakimoto, Yousuke Itou
  • Publication number: 20070031506
    Abstract: Whey protein is hydrolyzed with hydrolase so that a rate of hydrolysis is preferably 20 to 30%. A fraction, which has molecular weights above 10,000 daltons, is removed from a resultant hydrolysate by means of an ultrafiltration method to obtain a whey protein hydrolysate which is used as an active ingredient of an interleukin-18 inducer.
    Type: Application
    Filed: October 12, 2006
    Publication date: February 8, 2007
    Inventors: Hirotoshi Hayasawa, Yoshitaka Tamura, Hiroshi Miyakawa, Akio Yamada, Tetsuya Kuhara, Hiroshi Ochi
  • Publication number: 20060178337
    Abstract: Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
    Type: Application
    Filed: April 21, 2006
    Publication date: August 10, 2006
    Inventors: Shinya Suzu, Hiroaki Hageshita, Kouji Nomaguchi, Muneo Yamada, Hirotoshi Hayasawa
  • Patent number: 7081338
    Abstract: Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: July 25, 2006
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Shinya Suzu, Hiroaki Hageshita, Kouji Nomaguchi, Muneo Yamada, Hirotoshi Hayasawa
  • Patent number: 6908633
    Abstract: A protein hydrolysate comprising at least two types of peptides, characterized in that the rate of hydrolysis of protein is from 30 to 45%, the number average molecular weight is 300 or less, and the ratio of a weight average molecular weight to the number average molecular weight is greater than 1 and 2 or less, has excellent emulsifiability, and antigenicity thereof is low enough to be used for people who has predisposition to allergic diseases. This protein hydrolysate is obtained by hydrolysis of a protein starting material to a rate of hydrolysis in the range of 30 to 45%, and then bringing it into contact simultaneously or separately with two types of porous synthetic adsorbent respectively having an average pore radius of 2 to 8 nm and an average pore radius of 20 to 30 nm, the total surface area of the two porous synthetic adsorbents being in a range of 300 to 3000 m2 per 1 g (protein equivalent) of the obtained protein hydrolysate, and recovering the non-adsorbed component.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: June 21, 2005
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Hirotoshi Hayasawa, Yoshitaka Tamura, Hiroshi Miyakawa, Toshikazu Shichino, Yasushi Kawaguchi, Hirokatsu Kanehara
  • Patent number: 6867234
    Abstract: A fat composition for oral or enteral administration which contains eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: March 15, 2005
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Yasunobu Antoku, Kosuke Tsukamoto, Fumihiko Koike, Takashi Tokuyama, Hirotoshi Hayasawa, Mitsunori Takase, Kyoichi Oshida
  • Patent number: 6815419
    Abstract: The present invention provides antiulcer agents which can be orally administered while producing few side effects. These antiulcer agents contain &agr;-lactalbumin as an active ingredient, preferably in an amount of at least 0.5 mg/g.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: November 9, 2004
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Hirotoshi Hayasawa, Tomohiro Toida, Yukiko Shimokawa, Hiroshi Matsumoto
  • Publication number: 20040063633
    Abstract: Whey protein is hydrolyzed with hydrolase so that a rate of hydrolysis is preferably 20 to 30%. A fraction, which has molecular weights above 10,000 daltons, is removed from a resultant hydrolysate by means of an ultrafiltration method to obtain a whey protein hydrolysate which is used as an active ingredient of an interleukin-18 inducer.
    Type: Application
    Filed: June 23, 2003
    Publication date: April 1, 2004
    Inventors: Hirotoshi Hayasawa, Yoshitaka Tamura, Hiroshi Miyakawa, Akio Yamada, Tetsuya Kuhara, Hiroshi Ochi
  • Publication number: 20040028691
    Abstract: A fat composition for oral or enteral administration which contains eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.
    Type: Application
    Filed: April 29, 2003
    Publication date: February 12, 2004
    Inventors: Yasunobu Antoku, Kosuke Tsukamoto, Fumihiko Koike, Takashi Tokuyama, Hirotoshi Hayasawa, Mitsunori Takase, Kyoichi Oshida
  • Publication number: 20040013642
    Abstract: The present invention relates to an interferon therapeutic effect enhancer that contains lactoferrin as its active ingredient; the use of lactoferrin for the production of an interferon therapeutic effect enhancer; a pharmaceutical composition having interferon and lactoferrin as its active ingredients; and, a disease treatment method that includes administration of said pharmaceutical composition, said interferon therapeutic effect enhancer and said pharmaceutical composition being able to improve the therapeutic effects of interferon against various diseases without the occurrence of adverse side effects.
    Type: Application
    Filed: May 23, 2003
    Publication date: January 22, 2004
    Inventors: Katsuaki Tanaka, Hirotoshi Hayasawa, Susumu Teraguchi, Koji Yamauchi