Patents by Inventor Hirotoshi Numata

Hirotoshi Numata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7534800
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: May 19, 2009
    Assignee: Eisai R & D Development Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • Patent number: 7314940
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: January 1, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer, Darren Peter Medland, Hitoshi Oinuma, Gurpreet Bhatia
  • Patent number: 7291630
    Abstract: The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: November 6, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Gurpreet Bhatia, Darren Peter Medland
  • Publication number: 20060111390
    Abstract: The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Application
    Filed: March 17, 2003
    Publication date: May 25, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Gurpreet Bhatia, Darren Medland
  • Publication number: 20050272761
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Application
    Filed: March 17, 2003
    Publication date: December 8, 2005
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • Patent number: 5635519
    Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: June 3, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
  • Patent number: 5420144
    Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: May 30, 1995
    Assignee: Eisai Co., Ltd.
    Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
  • Patent number: 5329010
    Abstract: The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy groupR.sup.1 stands for a heteroarylalkyl group; andB stands for a carboxyl group or a protected carboxyl group.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: July 12, 1994
    Assignee: Eisai Co., Ltd.
    Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Tetsuya Kawahara, Naoki Kobayashi, Masanobu Shinoda, Koukichi Harada, Kaname Miyamoto, Koichi Abe
  • Patent number: 5300518
    Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;R.sup.2 represents a hydrogen atom and;R.sup.5 and R.sup.6 are the same or different and each represent a hydrogen atom or a lower alkyl group; or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: March 31, 1992
    Date of Patent: April 5, 1994
    Assignee: Eisai Co., Ltd.
    Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu