Abstract: To provide a new structure-dispersed composite in which a substance poorly soluble in a medium is dispersed as micronized particles, a core-shell structure is dispersed in the medium, wherein said core-shell structure contains microparticles therein, and consists of a core comp rising a core compound that is poorly soluble in said medium and a liquid shell comprising a shell compound that is poorly soluble in said medium, and the mean diameter of said core-shell structure is 10 ?m or less.

Abstract: The subject matter of the present invention is to provide a new particulate material dispersion composite in which a material poorly soluble in water is micronized and dispersed. For the above purpose, a particulate material dispersion composite is produced in the present invention, wherein a particulate material containing a specific material which is poorly soluble in water, a polymer and a lipid is dispersed in water, the mean diameter of said particulate material is 1 ?m or less, and the ratio of the combined weight of said polymer and said lipid to the weight of said specific material is 1.5 or larger.

Abstract: A method of producing fine particle-like materials formed by a crystallization method, which producing method is capable of producing the fine particles with a narrow particle size distribution and also capable of inhibiting aggregation of the fine particles without using any dispersant; and the fine particle-like materials, are provided. The present method of producing the fine particles by crystallization comprises preparing a solution containing the material to be finely divided, and bringing this solution into contact with a substrate having the microprojections provided on its surface at a density of not less than 100 projections/cm2 to cause precipitation of the fine particles. The fine particles produced by the above method are those of physiological active materials containing no dispersant.

Abstract: There is provided a process for producing fine particles of an organic compound by a continuous-type poor solvent precipitation method which is capable of rapidly and uniformly dispersing an organic compound-containing solution in a large amount of a poor solvent, thereby more readily producing fine particles of the organic compound having a volume-average particle size of not more than 1 ?m. In the process for producing fine particles of an organic compound, the poor solvent in which the organic compound is hardly soluble, is continuously mixed with the organic compound-containing solution prepared by dissolving the organic compound in a good solvent which is miscible with the poor solvent and in which the organic compound is readily soluble, while irradiating an ultrasonic wave thereto.