Patents by Inventor Hiroyoshi Hidaka
Hiroyoshi Hidaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4943581Abstract: An isoquinolinesulfonamide selected from those represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and each represent hydrogen or lower-alkyl, and X represents hydrogen or halogen, and pharmacologically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and use thereof in the treatment of circular disorders, are disclosed.Type: GrantFiled: June 26, 1989Date of Patent: July 24, 1990Assignees: Hokuriku Pharmaceutical Co., Ltd., Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Toshio Tanaka, Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Kazuya Mitani, Shunichiro Sakurai
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Patent number: 4798897Abstract: An isoquinoline derivative represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined in the disclosure, or a pharmacologically acceptable acid salt thereof. These compounds have an excellent relaxation action on blood vessels, particularly coronary arteries, and on bronchial tubes. Accordingly, the compounds can be advantageously utilized as drugs for prevention and treatment of angina, myocardial infarction, cardiovascular thrombosis, cerebrovascular thrombosis, hypertonia, asthma and other various circulatory and respiratory organ diseases.Type: GrantFiled: April 21, 1987Date of Patent: January 17, 1989Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Hiroyoshi Hidaka, Anri Morikawa
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Patent number: 4709032Abstract: This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.Type: GrantFiled: October 17, 1986Date of Patent: November 24, 1987Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Takanori Sone
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Patent number: 4678783Abstract: An isoquinolinesulfonyl compound represented by the formula (I): ##STR1## wherein R.sup.1 : H, Cl, OHA : unsubstituted or substituted ethylene or alkyleneR.sup.2, R.sup.3 : H, alkyl, jointly forming unsubstituted or substituted ethylene or trimethyleneR.sup.4 : H, alkyl, amidinoor an acid salt thereof.They can be prepared, for example, by converting 1-R.sup.1 substituted-5-isoquinolinesulfonic acid to the corresponding sulfonyl chloride and subsequently reacting the chloride with a compound of formula ##STR2## They can be advantageously utilized as vasodilator, cerebral circulation ameliorator, antihypertensive agent and drugs for prevention and treatment of various circulatory organ diseases.Type: GrantFiled: December 27, 1985Date of Patent: July 7, 1987Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Hiroyoshi Hidaka, Takanori Sone
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Patent number: 4634770Abstract: This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.Type: GrantFiled: November 4, 1983Date of Patent: January 6, 1987Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Takanori Sone
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Patent number: 4560755Abstract: A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least one;R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the ##STR2## wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR3## wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof.Type: GrantFiled: January 20, 1984Date of Patent: December 24, 1985Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Takanori Sone, Yasuharu Sasaki, Taisuke Sugihara
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Patent number: 4525589Abstract: A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least oneR.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; orthe ##STR2## group is a ##STR3## group wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR4## group wherein R.sub.7 is a C.sub.Type: GrantFiled: January 20, 1984Date of Patent: June 25, 1985Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Takanori Sone, Yasuharu Sasaki, Taisuke Sugihara
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Patent number: 4510307Abstract: A 6-quinazolinesulfonyl derivative of Formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1-12 alkyl group:R.sub.2 is a hydrogen atom, a C.sub.1-12 alkyl group, a C.sub.4-10 cycloalkyl group, an aryl group or an aralkyl group; andR.sub.1 and R.sub.2 may be linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring together with the adjacent nitrogen atom; andR.sub.3 is a ##STR2## group wherein R.sub.4 is a C.sub.1-8 alkyl group; a --HN(CH.sub.2).sub.n NH.sub.2 group wherein n is an integer of 2 to 10; or a ##STR3## group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.Type: GrantFiled: August 17, 1981Date of Patent: April 9, 1985Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Hiroyoshi Hidaka, Takanori Sone, Yasuharu Sasaki, Taisuke Sugihara, Seiji Takagi, Kiyohide Sako
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Patent number: 4456757Abstract: A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least one;R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; orthe ##STR2## group is a ##STR3## group wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, and aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR4## group wherein R.sub.7 is a C.sub.Type: GrantFiled: March 12, 1982Date of Patent: June 26, 1984Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Takanori Sone, Yasuharu Sasaki, Taisuke Sugihara
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Patent number: 4430342Abstract: An N-acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms,R.sup.2 represents a lower alkyl group,a lower alkoxy group or a phenyl group, andn represents zero or an integer of 1 to 10,and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 3-[4-(benzoylalkyl)-piperazin-1-yl]sydnonimine compound represented by the following formula ##STR2## wherein R.sup.1 and n are as defined, with a carboxylic acid represented by the following formulaR.sup.2 COOHwherein R.sup.2 is as defined.Type: GrantFiled: September 21, 1982Date of Patent: February 7, 1984Assignee: Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Ikuo Matsumoto, Junji Yoshizawa, Shigenori Kotani
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Patent number: 4421754Abstract: A 3-[4-(benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents zero or an integer of 1 to 10,and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 4-(benzoylalkyl)-1-(N-nitrosocyanomethylamino)piperazine represented by the following formula ##STR2## wherein R and n are as defined, with an acid.Type: GrantFiled: July 29, 1982Date of Patent: December 20, 1983Assignee: Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Ikuo Matsumoto, Junji Yoshizawa, Shigenori Kotani
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Patent number: 4125730Abstract: .omega.-Aminoalkanoic acid arylamides having the formula:R'(CH.sub.2).sub.n CONHRwherein R represents phenyl or naphthyl which can be substituted by halogen, nitro, alkyl, alkoxy, hydroxyl, acetoamino or alkoxycarbonyl; R' represents amino or acylated amino; and n is an integer of 4-8, exhibit blood platelet aggregation inhibiting effects.Type: GrantFiled: October 10, 1975Date of Patent: November 14, 1978Assignees: Banyu Pharmaceutical Co., Ltd., Hiroyoshi Hidaka, Nobuo AokiInventors: Hiroyoshi Hidaka, Ikuo Matsumoto, Yoshiaki Ito, Nobuo Aoki
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Patent number: 4069254Abstract: .omega.-(Arylsulfonamido)-alkylamines having the formulaR'-SO.sub.2 NH(CH.sub.2).sub.n R Iwherein R represents an amino group which can be acylated; R' represents phenyl or naphthyl which can be substituted by halogen or lower alkyl; and n represents an integer from 5 - 8 are effective in inhibiting blood platelet aggregation.Type: GrantFiled: October 7, 1975Date of Patent: January 17, 1978Assignees: Banyu Pharmaceutical Co., Ltd., Hiroyoshi Hidaka, Nobuo AokiInventors: Hiroyoshi Hidaka, Ikuo Matsumoto, Masaaki Hosoi, Nobuo Aoki