Patents by Inventor Hiroyoshi Minakuchi

Hiroyoshi Minakuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200116714
    Abstract: To provide a device capable of cancer diagnosis with high sensitivity and specificity, a cancer diagnosis device (1) includes: an extracellular vesicle capturing section (16 to 18) including immobilization supports on which lectins are immobilized respectively, the lectins being each capable of binding specifically to a surface sugar chain included in an extracellular vesicle derived from a cancer cell, the immobilization supports corresponding respectively to one or more kinds of the surface sugar chain; and a detecting section configured to detect a microRNA included in the extracellular vesicle.
    Type: Application
    Filed: November 11, 2019
    Publication date: April 16, 2020
    Inventors: Kanji HORI, Makoto HIRAYAMA, Ikuro MARUYAMA, Yoshihiro TAGUCHI, Hiroshi KUROKAWA, Kenya KOBAYASHI, Hiroyoshi MINAKUCHI
  • Publication number: 20140042066
    Abstract: A column container is formed in a bonding portion between a first support plate and a second support plate, and a column is held in the column container. An inlet channel connects the column container to a liquid inlet port. The inlet channel includes a first channel having a small diameter and a second channel having an increasing diameter. An inner surface of the second channel is a hemispherical surface. The radius of the column container is substantially the same as the radius of the hemispherical surface. The distance from an inflow end of the column to the boundary between the first channel and the second channel is substantially the same as the radius of the hemispherical surface.
    Type: Application
    Filed: August 8, 2013
    Publication date: February 13, 2014
    Inventors: Junko Ito, Hiroyoshi Minakuchi
  • Publication number: 20100276359
    Abstract: Provided is an absorption column for body fluid purification by which the saturated adsorption amount of a substance to be adsorbed can be increased or the time required for reaching the saturated adsorption can be shortened, and therefore, the column capacity can be considerably reduced and the treatment time can be considerably shortened. The adsorption column having functional groups 6 specifically binding to a substance to be adsorbed including at least low density lipoprotein, immobilized on the surface of a porous support 5.
    Type: Application
    Filed: September 8, 2008
    Publication date: November 4, 2010
    Applicant: REI Medical Co., Ltd.
    Inventors: Masamichi Ippommatsu, Chie Kurusu, Riichi Miyamoto, Sayaka Ishii, Kazuki Nakanishi, Hiroyoshi Minakuchi, Keiko Yano
  • Publication number: 20030230524
    Abstract: A chromatographic chip is formed of a plate member, a plurality of grooves formed on the plate member, and silica gel having monolithic bimodal pore structure formed in at least one of the grooves. The monolithic bimodal pore structure includes through pores and mesopores smaller than those of the through pores.
    Type: Application
    Filed: June 18, 2002
    Publication date: December 18, 2003
    Inventors: Naohiro Soga, Kazuki Nakanishi, Hiroyoshi Minakuchi
  • Patent number: 6531060
    Abstract: A capillary column comprising a capillary of which the inner diameter is less than 1000 &mgr;m and a continuous porous silica gel which uniformly fills the capillary, said silica gel containing both continuous through pores having diameters ranging from 0.5-5 &mgr;m and mesopores having diameters ranging from 2-50 nm.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: March 11, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Kazuki Nakanishi, Naohiro Soga, Hiroyoshi Minakuchi
  • Patent number: 5262469
    Abstract: The invention relates to an oxynitride glass fiber for composite products which has a surface cladding formed from a composition containing a silane coupling agent. This fiber is excellent in strength, elastic modulus, adhesion and wetting property with respect to matrix resin. A composite product comprising the above clad oxynitride glass fiber and a thermaplastic or thermosetting resin matrix is also disclosed. This composite is excellent in strength, elastic modulus, toughness and interlaminar shear resistance.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: November 16, 1993
    Assignee: Shimadzu Corporation
    Inventors: Haruo Osafune, Hiroyoshi Minakuchi
  • Patent number: 5024902
    Abstract: A fiber-reinforced metal comprising glass fibers and a matrix metal, said glass fibers having a nitrogen content of at least 8 atomic %. The fiber-reinforced metal has a high tensile strength and elasticity.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: June 18, 1991
    Assignee: Shimadzu Corporation
    Inventors: Katsuaki Suganuma, Hiroyuki Fujii, Hiroyoshi Minakuchi, Katsuhiko Kada, Haruo Osafune, Kuniaki Kanamaru
  • Patent number: 4957883
    Abstract: An oxynitride glass, a process for preparing same and a fiber thereof, in the glass which has Si--M.sub.1 --M.sub.2 --O--N system and contains SiO.sub.2, Si.sub.3 N.sub.4 and M.sub.1 O in amounts which, as mole %, satisfy the following equations (a) and (b):(SiO.sub.2 +3Si.sub.3 N.sub.4 +M.sub.1 O) X 100 / (100+2Si.sub.3 N.sub.4)=65 to less than 100 (a)(SiO.sub.2 +3Si.sub.3 N.sub.4)/M.sub.1 O=0.7 to 2.3 (b)wherein M.sub.1 is Ca, or Ca and Mg; M.sub.2 is at least one of the metal selected from the group consisting of Al, Sr, La, Ba, Y, Ti, Zr, Ce, Na, K, Sb, B, Cr, Pb, V and Sn, said glass containing 0-40 mole% SiO.sub.2, 26-70 mole % CaO, 0-20 mole % MgO, and over O to not more than 22 at % M.sub.2.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: September 18, 1990
    Assignee: Shimadzu Corporation
    Inventors: Junya Kobayashi, Masaaki Oota, Katsuhiko Kada, Hiroyoshi Minakuchi
  • Patent number: 4897468
    Abstract: Peptide-containing compounds such as enzymes, antibodies and antigens are immobilized on metal hydroxy gels formed by hydrolysis of metal alkoxides in an aqueous solvent while evaporating off the solvent. Preferably, hydrogen fluoride is present in the solvent during hydrolysis to provide a fluoride-substituted metal hydroxy gel. Water containing lower alcohol is a preferred solvent. The gel is treated with a coupling agent and a peptide-containing compound is chemically bonded to the gel.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: January 30, 1990
    Assignee: Shimadzu Corporation
    Inventors: Shotaro Oka, Shu Tahara, Hiroyoshi Minakuchi, Hajime Karatani