Abstract: The present disclosure provides anti-CCR4 chimeric antigen receptors (CARs) and compositions and methods for modified immune cells or precursors thereof (e.g., modified T cells) comprising anti-CCR4 CARs. Also provided are methods of using the anti-CCR4 CAR-expressing cells to treat cancer and T cell-depleting systems for use in combination with anti-CCR4 CAR T cell therapy.

Abstract: Provided is a canned motor in which vaporization of the handling liquid is reduced in a case where a rotor rotates at high speed. A canned motor 10 includes a stator 18 disposed in a stator chamber 26, a rotor 14 disposed in a rotor chamber 12, and a stator can 7 enclosing the rotor 14. Furthermore, the canned motor 10 includes a stator chamber inlet portion 43 configured such that a cooling liquid for cooling the stator 18 flows into the stator chamber 26, and a stator chamber outlet portion 44 configured such that the cooling liquid flows out from the stator chamber 26.

Abstract: A vehicle body rear part structure includes a bumper beam, an extension, and a gusset. The bumper beam extends in a vehicle width direction in a rear part of a vehicle body. The extension is provided for attaching the bumper beam to the vehicle body. The gusset is provided between the bumper beam and the extension and at an inner position in a vehicle width direction of the extension. A deformation facilitating part is provided on a middle part of the gusset.

Abstract: A vehicle body rear part structure includes a bumper beam, an extension, and a gusset. The bumper beam extends in a vehicle width direction in a rear part of a vehicle body. The extension is provided for attaching the bumper beam to the vehicle body. The gusset is provided between the bumper beam and the extension and at an inner position in a vehicle width direction of the extension. A deformation facilitating part is provided on a middle part of the gusset.

Abstract: The present invention relates to an inducer geometry which can optimize the behavior stability of cavitation in an inducer having a plurality of blades of the same geometry. In the inducer having a plurality of blades of the same geometry, a blade loading at a tip side in a front half of a blade is larger than that in a rear half of the blade; and when a blade angle from a circumferential direction of the inducer is expressed by ?b (degree) and a meridional distance is expressed by m (mm), an increase rate d?b/dm of the blade angle at the tip side is not less than 0.2 from a blade leading edge to a non-dimensional meridional location of 0.15, and the increase rate d?b/dm of the blade angle at a mid-span is not less than 0.25 from the blade leading edge to the non-dimensional meridional location of 0.15.

Abstract: In a fluid machine, there is provided each diffuser flow passage for making uniform a flow in a downstream of a diffuser. The fluid machine is provided, and it has the diffuser for converting kinetic energy of a fluid into pressure energy. The diffuser has first and second diffuser flow passages configured so that the fluid passes through them, and shapes of the first and second diffuser flow passages are different from each other.

Abstract: A stent delivery system for delivering a stent, the stent delivery system having a push catheter, a guide member, and an elongated stent securing material having a first portion arranged to a push catheter outer surface, a second portion, a third portion, and a fourth portion arranged to the push catheter outer surface, in that order. The first portion and the fourth portion are arranged to the push catheter outer surface such that only one of the first portion and the fourth portion is present on a cross-section plane orthogonal to the longitudinal axis. The stent delivery system is configured to have a secured configuration in which the guide member is arranged within a push catheter lumen and a stent lumen and through a loop formed by a section between the second portion and the third portion to secure the stent.

Abstract: A stent delivery system for delivering a stent, the stent delivery system having a push catheter, a guide member, and an elongated stent securing material having a first portion arranged to a push catheter outer surface, a second portion, a third portion, and a fourth portion arranged to the push catheter outer surface, in that order. The first portion and the fourth portion are arranged to the push catheter outer surface such that only one of the first portion and the fourth portion is present on a cross-section plane orthogonal to the longitudinal axis. The stent delivery system is configured to have a secured configuration in which the guide member is arranged within a push catheter lumen and a stent lumen and through a loop formed by a section between the second portion and the third portion to secure the stent.

Abstract: The present invention relates to an inducer geometry which can optimize the behavior stability of cavitation in an inducer having a plurality of blades of the same geometry. In the inducer having a plurality of blades of the same geometry, a blade loading at a tip side in a front half of a blade is larger than that in a rear half of the blade; and when a blade angle from a circumferential direction of the inducer is expressed by ?b (degree) and a meridional distance is expressed by m (mm), an increase rate d?b/dm of the blade angle at the tip side is not less than 0.2 from a blade leading edge to a non-dimensional meridional location of 0.15, and the increase rate d?b/dm of the blade angle at a mid-span is not less than 0.25 from the blade leading edge to the non-dimensional meridional location of 0.15.

Abstract: A collision load is appropriately absorbed even in a case that the collision load is intersectionally input from the oblique rear with respect to the vehicle longitudinal direction. Plural first to sixth corner portions provided at the rear end of an extension are arranged such as to be located at respective different positions along the vehicle longitudinal direction, wherein the first corner portion located at the vehicle transverse inner upper end is located the rearmost, and wherein the first to sixth corner portions and first to sixth edge lines, which form the rear end of the extension, are provided such as to be located at the rear in a spiral form from the first corner portion toward the vehicle front in order.

Abstract: A method for producing a solution containing at least an unsaturated carboxylic acid-modified vinyl alcohol polymer is characterized by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound in the presence of an acid catalyst soluble in the reaction system or a solid acid catalyst, and a gas barrier film is obtained by using the same. An example thereof is a method for producing a solution (A) containing an unsaturated carboxylic acid-modified vinyl alcohol polymer (b), the method comprising following two steps of: (1) a reaction step in which the unsaturated carboxylic acid-modified vinyl alcohol polymer (b) is formed by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound (a) in the presence of an acid catalyst soluble in the reaction system; and (2) an ion exchange step in which at least the acid catalyst of acidic compounds is removed by an anion exchange resin.

Abstract: A collision load is appropriately absorbed even in a case that the collision load is intersectionally input from the oblique rear with respect to the vehicle longitudinal direction. Plural first to sixth corner portions provided at the rear end of an extension are arranged such as to be located at respective different positions along the vehicle longitudinal direction, wherein the first corner portion located at the vehicle transverse inner upper end is located the rearmost, and wherein the first to sixth corner portions and first to sixth edge lines, which form the rear end of the extension, are provided such as to be located at the rear in a spiral form from the first corner portion toward the vehicle front in order.

Abstract: This endoscopic treatment system is provided with an insertion-retraction and rotating device for a treatment tool, which performs an insertion-retraction operation along a direction of an axis of a treatment tool and a rotating operation around the axis, of the treatment tool inserted in a channel of an endoscope.

Abstract: An ultrasonic treatment apparatus includes a sheath having an opening at a distal end thereof; an ultrasonic transducer provided at a distal portion of the sheath and generating ultrasonic vibration; an ultrasonic transmission member connected to the ultrasonic transducer at a proximal end thereof, transmitting the ultrasonic vibration, and provided with a treatment part at a distal end thereof; a gripper moving to the treatment part and grasping the part to be treated between the gripper and the treatment part; a link member connected to the gripper and provided on a side of the ultrasonic transmission member; a manipulator part connected to a proximal end part of the link member to open and close the gripper; and a rigid member which the ultrasonic transducer is inserted into and secured to.

Abstract: A hemostatic forceps for an endoscope has a support section for supporting the pair of clamp pieces and so that they can rotate and change their distal parts direction. The pair of clamp pieces and are formed in tapered shape so that widths of the pair of clamp pieces gradually decrease in a direction from a side of the support section to a side of the distal parts. Length of the pair of clamp pieces at arbitrary location along the direction from a side of the support section to the distal sides, times the width of the pair of clamp pieces at the same location, is set to be substantially constant.

Abstract: A high-frequency treatment instrument that is used with high-frequency electric current supplied from a power source, which includes: a pair of forceps members connected with each other by a rotational axis; and an operation wire having a distal end portion which is rotationally connected to proximal end portions of the forceps members and a proximal end portion which is electrically connected with the power source, in which at least one of the pair of forceps members has a conductive electrode portion, and an insulating portion disposed so as to cover at least part of the electrode portion, the operation wire is electrically connected with the electrode portions, and a conductive outer surface of the forceps members, which includes a portion where the operation wire and the electrode portion are electrically connected, located closer to the proximal end portions of the forceps members than the rotational axis of the forceps members is covered by the insulating portion so as not to be exposed.

Abstract: The present invention provides an industrially advantageous method for producing an unsaturated carboxylic acid-modified vinyl alcohol polymer, and a gas barrier film obtained by using the same.

Abstract: An ultrasonic treatment apparatus comprises an endoscope having an insertion portion to be inserted in a body cavity, and a treatment unit having an ultrasonic vibrator which generates ultrasonic vibrations, and a treatment portion which performs treatment by utilizing the ultrasonic vibrations generated by the ultrasonic vibrator. The ultrasonic treatment apparatus further comprises a treatment unit holding portion, which is provided in a distal end portion of the insertion portion and to which the treatment unit is attached, a cable which transmits an electric signal to the ultrasonic vibrator, and at least one bundle member which bundles the insertion portion and the cable.

Abstract: An ultrasonic transducer unit that generates ultrasonic vibration for treating living tissues has an ultrasonic transducer and a cover member that covers the ultrasonic transducer. A flexible sheath is coupled at one end to the cover member. A signal cable extends through the sheath and is connected at one end to the ultrasonic transducer. A transducer drive unit is connected to the other end of the signal cable. An operation unit is provided at the other end of the flexible sheath.