Abstract: The present invention relates to a polypeptide comprising an antigen binding domain and a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, methods for producing and screening for the polypeptide, a pharmaceutical composition comprising the polypeptide, methods for producing and screening for a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH, and a fusion polypeptide library including a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH.

Abstract: An image processing apparatus includes a storage and processing circuitry. The storage is configured to store a dither table in which a plurality of dither patterns are recorded, each of the dither patterns being formed with a halftone dot screen in which an output area ratio that is a proportion of void halftone dots per unit area corresponds to any one of gradation values of image data. The processing circuitry is configured to read a gradation value for each region in image data input for each toner color, decide a dither pattern to be applied to the read gradation value, read out the decided dither pattern from the dither table, and perform dither processing of applying the read dither pattern to the region in the image data.

Abstract: An image processing apparatus includes a storage and processing circuitry. The storage is configured to store a dither table in which a plurality of dither patterns are recorded, each of the dither patterns being formed with a halftone dot screen in which an output area ratio that is a proportion of void halftone dots per unit area corresponds to any one of gradation values of image data. The processing circuitry is configured to read a gradation value for each region in image data input for each toner color, decide a dither pattern to be applied to the read gradation value, read out the decided dither pattern from the dither table, and perform dither processing of applying the read dither pattern to the region in the image data.

Abstract: An image processing apparatus includes: an image determining unit configured to determine a gradation value for each predetermined range in input image data; and a screen generator configured to arrange dot images around a plurality of growth centers in a halftone dot screen to form respective dot blocks if an input area rate indicating a ratio of black to white in dot images at the gradation value is smaller than a value at which an image defect occurs, and form bridges to connect adjacent dot blocks during a smallest gradation number if distances between the adjacent dot blocks decrease to a predetermined value or less along with growth of the dot blocks, to form a void halftone dot image.

Abstract: An image processing apparatus stores a first dither pattern group that includes dither patterns each corresponding to a gradation value in a first range and formed by line screens in which widths of lines are increased with an increase in the gradation value, a second dither pattern group that includes dither patterns each corresponding to a gradation value in a second range higher than the gradation value in the first range, and formed by void dot screens in which number of dots is increased and void regions surrounded by the dots are decreased with an increase in the gradation value, and a third dither pattern group that includes dither patterns for switching from the line screen to the void dot screen, switching to the void dot screen being completed before a first reference gradation value at which an image defect occurs for received image data is reached.

Abstract: An image processing apparatus includes: an image determining unit configured to determine a gradation value for each predetermined range in input image data; and a screen generator configured to arrange dot images around a plurality of growth centers in a halftone dot screen to form respective dot blocks if an input area rate indicating a ratio of black to white in dot images at the gradation value is smaller than a value at which an image defect occurs, and form bridges to connect adjacent dot blocks during a smallest gradation number if distances between the adjacent dot blocks decrease to a predetermined value or less along with growth of the dot blocks, to form a void halftone dot image.

Abstract: An aspect of the invention provides an image forming apparatus storing first, second, and third dither pattern groups. The first group contains a plurality of line screens, each associated with one of gray levels in a first range, varying such that as the gray level increases, the line width increases. The second group contains a plurality of void-dot screens, each associated with one of gray levels higher than those in the first range, varying such that as the gray level increases, dots increase to reduce void portions surrounded by the dots. The third group contains, for switching from the line screen to the void-dot screen, a plurality of dither patterns varying such that as the gray level increases from a reference gray level, adjacent lines are connected at joint portions tapered toward tip ends in a manner that a position that gradually advances from the tip ends to basal ends.

Abstract: An image processing apparatus stores a first dither pattern group that includes dither patterns each corresponding to a gradation value in a first range and formed by line screens in which widths of lines are increased with an increase in the gradation value, a second dither pattern group that includes dither patterns each corresponding to a gradation value in a second range higher than the gradation value in the first range, and formed by void dot screens in which number of dots is increased and void regions surrounded by the dots are decreased with an increase in the gradation value, and a third dither pattern group that includes dither patterns for switching from the line screen to the void dot screen, switching to the void dot screen being completed before a first reference gradation value at which an image defect occurs for received image data is reached.

Abstract: An aspect of the invention provides an image forming apparatus storing first, second, and third dither pattern groups. The first group contains a plurality of line screens, each associated with one of gray levels in a first range, varying such that as the gray level increases, the line width increases. The second group contains a plurality of void-dot screens, each associated with one of gray levels higher than those in the first range, varying such that as the gray level increases, dots increase to reduce void portions surrounded by the dots. The third group contains, for switching from the line screen to the void-dot screen, a plurality of dither patterns varying such that as the gray level increases from a reference gray level, adjacent lines are connected at joint portions tapered toward tip ends in a manner that a position that gradually advances from the tip ends to basal ends.

Abstract: An electrophotographic image output device includes an image processor to receive input image data, and a line screen to represent halftone images and have multiple screen angles respectively allocated to different colors including yellow, magenta, and cyan. The line screen satisfies requirements of (A) a predetermined difference is secured between adjacent two of the multiple screen angles; (B) zero is not allocated to any of the multiple screen angles; and (C) among the multiple screen angles determined by the requirements (A) and (B), a screen angle closest to 90 degrees is allocated to yellow among yellow, magenta, and cyan.

Abstract: An image processing method for generating a halftone pattern for forming an image according to input image data includes a step of forming first and second shade patterns to be developed by first and second toners, respectively. The second toner is identical in color to the first toner and different in shade from the first toner, and the second shade pattern is shifted from the first shade pattern.

Abstract: An electrophotographic image output device includes an image processor to receive input image data, and a line screen to represent halftone images and have multiple screen angles respectively allocated to different colors including yellow, magenta, and cyan. The line screen satisfies requirements of (A) a predetermined difference is secured between adjacent two of the multiple screen angles; (B) zero is not allocated to any of the multiple screen angles; and (C) among the multiple screen angles determined by the requirements (A) and (B), a screen angle closest to 90 degrees is allocated to yellow among yellow, magenta, and cyan.

Abstract: An image processing apparatus comprises a dither processing device that applies dither processing to input image data to express halftone using line screens by increasing an area rate of the input image data and a controller that decreases the number of line screens and maintains a prescribed dropout width between the neighboring line screens when the area rate of the input image data increases and the dropout width falls below a prescribed level.

Abstract: An image processing method for generating a halftone pattern for forming an image according to input image data includes a step of forming first and second shade patterns to be developed by first and second toners, respectively. The second toner is identical in color to the first toner and different in shade from the first toner, and the second shade pattern is shifted from the first shade pattern.

Abstract: An image processing apparatus comprises a dither processing device that applies dither processing to input image data to express halftone using line screens by increasing an area rate of the input image data and a controller that decreases the number of line screens and maintains a prescribed dropout width between the neighboring line screens when the area rate of the input image data increases and the dropout width falls below a prescribed level.

Abstract: A piezoelectric diaphragm pump assembly is disclosed, wherein there is disposed a housing having an inlet port provided with a feed check valve, and an outlet port provided with a discharge check valve, wherein a casing is disposed for accomodating an amplification mechanism, said casing having an L-shape stationary member, to which a plate spring is fixed, a front end portion of the plate spring being fixed with a lever member of the amplification mechanism, which is engaged with an upper portion of a longitudinally effective type piezoelectric actuator, and wherein a diaphragm body coated with a film is disposed, characterized in that a front end portion of the lever member is fixed with a supporting member which is, in turn, fixed with a U-shape supporting member for supporting the diaphragm body, and that the supporting member is connected via a spring to the L-shape stationary member.