Abstract: The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

Abstract: A plurality of conductive patterns constituting first, second, and third inductors are formed in a multi-layer wiring board. A fifth dielectric layer is disposed between second to fourth dielectric layers having the first inductor and a seventh dielectric layer having the second inductor. First and second electrode layers are disposed facing each other across the fifth dielectric layer so as to constitute a capacitor. The capacitor is disposed between the first and third inductors and the second inductor. The first electrode layer, i.e., one electrode of the capacitor, is a ground layer.

Abstract: A plurality of conductive patterns constituting first, second, and third inductors are formed in a multi-layer wiring board. A fifth dielectric layer is disposed between second to fourth dielectric layers having the first inductor and a seventh dielectric layer having the second inductor. First and second electrode layers are disposed facing each other across the fifth dielectric layer so as to constitute a capacitor. The capacitor is disposed between the first and third inductors and the second inductor. The first electrode layer, i.e., one electrode of the capacitor, is a ground layer.

Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Abstract: An isolated 16S rDNA having a nucleotide sequence selected from SEQ ID NOs: 1, 2, 3, and 4. The invention also relates to an RNA or DNA probe with a length ranging from 10 to 50 bases which comprises at least one nucleotide sequence selected from SEQ ID NOs: 1, 2, 3, and 4; and wherein the probe is hybridizable specifically with a petroleum-degrading bacterium belonging to the genus Cycloclasticus. The invention also relates to isolated 16S rDNA useful for detecting and screening for petroleum-degrading bacteria.

Abstract: A method of detecting and quantitating a petroleum-digesting microorganism and its gene from natural environment. In one embodiment, the microorganism is a bacterium belonging to the genus Cycloclasticus. The invention also relates to a method for detecting and quantitating a petroleum-degrading bacterium belonging to the genus Cycloclasticus comprising using an RNA or DNA probe having a length of from 10 to 50 bases with a part of the nucleotide sequence of the probe represented by any of SEQ ID NOS: 1 to 4; and wherein the probe is hybridizable specifically with a petroleum-degrading bacterium belonging to the genus Cycloclasticus.

Abstract: A composite capacitor includes a laminated substrate in which a plurality of dielectric layers and a plurality of conductive layers are laminated alternately. The laminated substrate includes a first common electrode that is composed of the corresponding conductive layer and is provided in laminated layers of the laminated substrate, a first electrode that is composed of the corresponding conductive layer and is disposed above the first common electrode with one of the dielectric layers between the first electrode and the first common electrode, and a second electrode that is composed of the corresponding conductive layer and is disposed below the first common electrode with one of the dielectric layers between the second electrode and the first common electrode. Each of the first and second electrodes, which oppose the first common electrode, is disposed within an area of the first common electrode.

Abstract: A diplexer contains a common terminal connected to an antenna, a first input/output terminal for inputting/outputting signals of a plurality of high frequency bands higher than a predetermined frequency, and a second input/output terminal for inputting/outputting signals of low frequency bands lower than the predetermined frequency. Between the common terminal and the first input/output terminal, a high pass filter and a low trap circuits for attenuating the low frequency bands respectively are interposed in series, and, between the common terminal and the second input/output terminal, a low pass filter and high trap circuits for attenuating the high frequency bands respectively are interposed in series.

Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Abstract: A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4): wherein, in formula (2), R1 is a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Y1 and Y2 each is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), R2 and R3 each is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.

Abstract: The present invention relates to diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.

Abstract: A process for preparing a biphenylcarboxylic acid amide derivative represented by the following formula (1): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a substituent, which comprises reacting, in the presence of a metal catalyst, a halogenobenzoic acid derivative represented by the following formula (2): wherein, X represents a halogen atom with a compound represented by the following formula (3): wherein, R1, R2 and R3 have the same meanings as described above, and Y represents an leaving group having an element selected from the group consisting of boron, silicon, zinc, tin and magnesium; or salt thereof. According to the present invention, biphenylcarboxylic acid amide derivatives of the formula (1) or salts thereof having excellent inhibitory activity against IgE antibody production can be prepared by the reduced number of steps, conveniently, at lower cost and in a high yield.

Abstract: The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Abstract: A process for preparing a biphenylcarboxylic acid amide derivative represented by the following formula (1): 1

Abstract: The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.

Abstract: Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or heterocyclic groups or —S— or —O—; Y is a single bond or an alkylene group; Z is an unsubstituted aliphatic group or divalent residue of benzene or pyridine, which is optionally substituted; anis hydrogen, lower alkyl, cycloalkyl, aryl or aralkyl; with certain provisos. These compounds exhibit an inhibitory effect on the production of IgE antibodies and are, hence, useful as antiallergic agents.

Abstract: The invention relates to compounds represented by the following general formula (1): 1

Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: 1

Abstract: A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof: 1