Patents by Inventor Hiroyuki Kaji
Hiroyuki Kaji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11571473Abstract: An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.Type: GrantFiled: June 6, 2019Date of Patent: February 7, 2023Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL, SCIENCE AND TECHNOLOGY, UNIVERSITY OF TOYAMAInventors: Hisashi Narimatsu, Kiyohiko Angata, Hiroyuki Kaji, Atsushi Kuno, Takashi Sato, Yasunori Chiba, Akira Togayachi, Hiroki Shimizu, Maki Sogabe, Takanori Wagatsuma, Masashi Mizokami, Masaaki Korenaga, Kazuto Tajiri, Tatsuhiko Ozawa
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Publication number: 20210283246Abstract: An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.Type: ApplicationFiled: June 6, 2019Publication date: September 16, 2021Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, UNIVERSITY OF TOYAMAInventors: Hisashi NARIMATSU, Kiyohiko ANGATA, Hiroyuki KAJI, Atsushi KUNO, Takashi SATO, Yasunori CHIBA, Akira TOGAYACHI, Hiroki SHIMIZU, Maki SOGABE, Takanori WAGATSUMA, Masashi MIZOKAMI, Masaaki KORENAGA, Kazuto TAJIRI, Tatsuhiko OZAWA
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Patent number: 10539576Abstract: An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.Type: GrantFiled: June 12, 2017Date of Patent: January 21, 2020Assignees: National Institute of Advanced Industrial Science and Technology, Tokyo Medical UniversityInventors: Hisashi Narimatsu, Akira Togayachi, Yuzuru Ikehara, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Hideki Matsuzaki, Yoshitoshi Hirao, Jun Iwaki, Minako Abe, Masaharu Nomura, Masayuki Noguchi
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Patent number: 10506186Abstract: [Object] To provide a solid-state imaging device, with which degradation of properties of a solid-state image sensor under the influence of magnetic force lines generated from wiring arranged in the package is prevented, and a solid-state imaging apparatus including the same. [Solving Means] A solid-state imaging device according to the present technology includes a package, a seal glass, a solid-state image sensor, and a shield. The package includes wiring inside and a recess. The seal glass is joined to the package and closes the recess. The solid-state image sensor is housed in a space formed by the recess and the seal glass. The shield is housed in the space and arranged on the package. The shield prevents an arrival of magnetic force lines generated from the wiring at the solid-state image sensor.Type: GrantFiled: October 14, 2016Date of Patent: December 10, 2019Assignee: SONY CORPORATIONInventors: Atsushi Tsukada, Eiichirou Kishida, Daisuke Nakatsuru, Hiroyuki Kaji
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Patent number: 10358466Abstract: A Wisteria floribunda monomeric lectin polypeptide is provided. The Wisteria floribunda monomeric lectin polypeptide includes any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are deleted, substituted, inserted, or added; and (3) the amino acid sequence defined in (1) or (2) above, further having an N-terminus deletion of one to 30 amino acids, in which Cys272 is alkylated, and the polypeptide is capable of specifically binding to a GalNAc terminal sugar chain.Type: GrantFiled: September 15, 2017Date of Patent: July 23, 2019Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE & TECHNOLOGYInventors: Takashi Sato, Yasunori Chiba, Hiroaki Tateno, Hiroyuki Kaji, Masanori Goto, Hisashi Narimatsu
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Publication number: 20190098237Abstract: [Object] To provide a solid-state imaging device, with which degradation of properties of a solid-state image sensor under the influence of magnetic force lines generated from wiring arranged in the package is prevented, and a solid-state imaging apparatus including the same. [Solving Means] A solid-state imaging device according to the present technology includes a package, a seal glass, a solid-state image sensor, and a shield. The package includes wiring inside and a recess. The seal glass is joined to the package and closes the recess. The solid-state image sensor is housed in a space formed by the recess and the seal glass. The shield is housed in the space and arranged on the package. The shield prevents an arrival of magnetic force lines generated from the wiring at the solid-state image sensor.Type: ApplicationFiled: October 14, 2016Publication date: March 28, 2019Applicant: SONY CORPORATIONInventors: ATSUSHI TSUKADA, EIICHIROU KISHIDA, DAISUKE NAKATSURU, HIROYUKI KAJI
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Publication number: 20180134756Abstract: A Wisteria floribunda monomeric lectin polypeptide is provided. The Wisteria floribunda monomeric lectin polypeptide includes any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are deleted, substituted, inserted, or added; and (3) the amino acid sequence defined in (1) or (2) above, further having an N-terminus deletion of one to 30 amino acids, in which Cys272 is alkylated, and the polypeptide is capable of specifically binding to a GalNAc terminal sugar chain.Type: ApplicationFiled: September 15, 2017Publication date: May 17, 2018Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Takashi Sato, Yasunori Chiba, Hiroaki Tateno, Hiroyuki Kaji, Masanori Goto, Hisashi Narimatsu
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Patent number: 9796761Abstract: The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.Type: GrantFiled: July 12, 2010Date of Patent: October 24, 2017Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE, GLYCOBIOMARKER LEADING INNOVATION CO., LTD.Inventors: Hisashi Narimatsu, Jun Hirabayashi, Yuzuru Ikehara, Takashi Angata, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Toshihide Shikanai, Maki Sogabe, Akira Togayachi, Makoto Ochou, Yasuhito Tanaka, Masashi Mizokami
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Patent number: 9796765Abstract: [Problem] The purpose of the present invention is to stably supply high-quality and highly uniform Wisteria floribunda agglutinin (WFA) that recognizes biologically important sugar-chain markers, to elucidate the sugar-chain recognition activity in detail, and to furthermore increase the specificity of the sugar-chain recognition activity. [Solution] The present invention involves the development of a technique for cloning genes for coding Wisteria floribunda agglutinin (WFA) and producing recombinant WFA having the same sugar-chain recognition activity as natural WFA from transformed bacteria. Natural WFA is reduced to thereby manufacture a reduced WFA monomer for specifically recognizing terminal GalNAc residue. A recombinant monomer WFA for recognizing LDN (GalNAc?1, 4GlcNAc) sugar chain, which is important as a diagnostic marker among sugar chains having a terminal GalNAc residue, is manufactured by introducing cysteine mutation to recombinant WFA or by C-terminal-side amino acid deletion.Type: GrantFiled: December 18, 2013Date of Patent: October 24, 2017Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Takashi Sato, Yasunori Chiba, Hiroaki Tateno, Hiroyuki Kaji, Masanori Goto, Hisashi Narimatsu
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Publication number: 20170283506Abstract: An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.Type: ApplicationFiled: June 12, 2017Publication date: October 5, 2017Applicants: National Institute of Advanced Industrial Science and Technology, Tokyo Medical UniversityInventors: Hisashi Narimatsu, Akira Togayachi, Yuzuru Ikehara, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Hideki Matsuzaki, Yoshitoshi Hirao, Jun Iwaki, Minako Abe, Masaharu Nomura, Masayuki Noguchi
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Publication number: 20170219590Abstract: The problem addressed by the present invention is to provide a marker for detecting hepatocellular carcinoma, wherein the hepatocellular carcinoma marker comprises a glycoprotein that first becomes present in the liver with the occurrence of cancer, without depending on changes in the state of the liver.Type: ApplicationFiled: July 22, 2015Publication date: August 3, 2017Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Atsushi KUNO, Takashi SATO, Atsushi MATSUDA, Hisashi NARIMATSU, Hiroyuki KAJI, Akira TOGAYACHI, Ken SHIRABE, Yoshihiko MAEHARA
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Patent number: 9696320Abstract: An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.Type: GrantFiled: September 9, 2011Date of Patent: July 4, 2017Assignees: National Institute of Advanced Industrial Science and Technology, Tokyo Medical UniversityInventors: Hisashi Narimatsu, Akira Togayachi, Yuzuru Ikehara, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Hideki Matsuzaki, Yoshitoshi Hirao, Jun Iwaki, Minako Abe, Masaharu Nomura, Masayuki Noguchi
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Publication number: 20150329602Abstract: [Problem] The purpose of the present invention is to stably supply high-quality and highly uniform Wisteria floribunda agglutinin (WFA) that recognizes biologically important sugar-chain markers, to elucidate the sugar-chain recognition activity in detail, and to furthermore increase the specificity of the sugar-chain recognition activity. [Solution] The present invention involves the development of a technique for cloning genes for coding Wisteria floribunda agglutinin (WFA) and producing recombinant WFA having the same sugar-chain recognition activity as natural WFA from transformed bacteria. Natural WFA is reduced to thereby manufacture a reduced WFA monomer for specifically recognizing terminal GalNAc residue. A recombinant monomer WFA for recognizing LDN (GalNAc?1, 4GlcNAc) sugar chain, which is important as a diagnostic marker among sugar chains having a terminal GalNAc residue, is manufactured by introducing cysteine mutation to recombinant WFA or by C-terminal-side amino acid deletion.Type: ApplicationFiled: December 18, 2013Publication date: November 19, 2015Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE TECHNOLOGYInventors: Takashi Sato, Yasunori Chiba, Hiroaki Tateno, Hiroyuki Kaji, Masanori Goto, Hisashi Narimatsu
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Publication number: 20150293104Abstract: An object of the present invention is to develop and provide an epithelial ovarian cancer diagnosis marker with which epithelial ovarian cancer can be detected inexpensively, conveniently, and low invasively with high accuracy, and a method for determining the presence or absence of epithelial ovarian cancer using the marker. The present invention provides a glycoprotein having a glycan-linked asparagine residue at a particular site of the glycoprotein secreted from an epithelial ovarian cancer cell, or a fragment thereof having the glycan as an epithelial ovarian cancer diagnosis marker. The present invention also provides a method for determining the presence or absence of epithelial ovarian cancer using the glycoprotein.Type: ApplicationFiled: July 12, 2012Publication date: October 15, 2015Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Hirofumi Nozaki, Takashi Ohkura, Atsushi Kuno, Maki Sogabe, Tomomi Kubota, Hiroyuki Kaji, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hayao Nakanishi, Toru Nakanishi
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Publication number: 20130288272Abstract: An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.Type: ApplicationFiled: September 9, 2011Publication date: October 31, 2013Applicants: TOKYO MEDICAL UNIVERSITY, NATIONAL INSTIUTE OF ADVANCED INDUSTRIAL SCIENCE AInventors: Hisashi Narimatsu, Akira Togayachi, Yuzuru Ikehara, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Hideki Matsuzaki, Yoshitoshi Hirao, Jun Iwaki, Minako Abe, Masaharu Nomura, Masayuki Noguchi
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Publication number: 20120190576Abstract: The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.Type: ApplicationFiled: July 12, 2010Publication date: July 26, 2012Inventors: Hisashi Narimatsu, Jun Hirabayashi, Yuzuru Ikehara, Takashi Angata, Hiroyuki Kaji, Atsushi Kuno, Takashi Ohkura, Toshihide Shikanai, Maki Sogabe, Akira Togayachi, Makoto Ochou, Yasuhito Tanaka, Masashi Mizokami
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Patent number: 7467079Abstract: A text classification apparatus directed to a plurality of languages, includes a unit for extracting information for converting a word from non-classified (unlabeled) texts, in a plurality of languages, into a word sense, a unit for learning a classification knowledge at a word sense level after converting a word extracted from a labeled text into a word sense, a unit for learning a classification knowledge at a word level from the labeled text, a unit for learning the classification knowledge at the word level from the classification knowledge at the word sense level and information on a relation between words extracted from the unlabeled text, and a unit for combining the respective classification knowledges to assign a category.Type: GrantFiled: February 24, 2004Date of Patent: December 16, 2008Assignee: Hitachi, Ltd.Inventors: Yasutsugu Morimoto, Hiroyuki Kaji, Osamu Imaichi
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Patent number: 7240051Abstract: A system allows related documents to be retrieved using conventional search engines while overcoming the ambiguity of a search key entered by the user. The system includes a word sense associative network display portion for displaying word senses of the search key entered by the user together with related word senses in a network, a search portion for conducting a search by generating a search key based on word senses selected by the user, and a filtering portion for selecting documents from the result of the search that matches the selected word sense.Type: GrantFiled: February 24, 2004Date of Patent: July 3, 2007Assignee: Hitachi, Ltd.Inventors: Osamu Imaichi, Hiroyuki Kaji
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Patent number: 7047195Abstract: A translation device which has both advantages of a table look-up translation device and advantages of a machine translation device by leading the user's utterance through a sentence template suitable for the user's intent of speech is realized. Since the translation device searches for sentence templates suitable for the user's intent of speech with an orally inputted keyword and displays retrieved sentences, the user's utterance can be lead. In addition, the user is free from a troublesome manipulation for replacing a word since an expression uttered by the user is inserted into a replaceable portion (slot) within the sentence template, and the translation device translates a resulting sentence with the replaced expression embedded in the slot.Type: GrantFiled: January 26, 2005Date of Patent: May 16, 2006Assignee: Hitachi, Ltd.Inventors: Atsuko Koizumi, Hiroyuki Kaji, Yasunari Obuchi, Yoshinori Kitahara
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Patent number: 6917920Abstract: A translation device which has both advantages of a table look-up translation device and advantages of a machine translation device by leading the user's utterance through a sentence template suitable for the user's intent of speech is realized. Since the translation device searches for sentence templates suitable for the user's intent of speech with an orally inputted keyword and displays retrieved sentences, the user's utterance can be lead. In addition, the user is free from a troublesome manipulation for replacing a word since an expression uttered by the user is inserted into a replaceable portion (slot) within the sentence template, and the translation device translates a resulting sentence with the replaced expression embedded in the slot.Type: GrantFiled: January 6, 2000Date of Patent: July 12, 2005Assignee: Hitachi, Ltd.Inventors: Atsuko Koizumi, Hiroyuki Kaji, Yasunari Obuchi, Yoshinori Kitahara