Abstract: A power conversion device includes a power converter including a semiconductor module, to convert input power and output the converted power, and a capacitor electrically connected to the semiconductor module. The capacitor includes a capacitor-side terminal surface on which a capacitor-side terminal is arranged, and the capacitor-side terminal surface faces a module-side terminal surface of the semiconductor module.

Abstract: The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.

Abstract: A method for disease-gene prioritization includes building a heterogenous network to include gene nodes gj and disease nodes di; supplying additional information (xdi, xgj) related to the gene nodes gj and the disease nodes di to generate embeddings zk associated with the gene nodes gj and the disease nodes di; applying a graph convolutional neural network model G to the heterogenous network and to the embeddings zk to calculate aggregated embeddings zk+1; and estimating, with an edge decoder model ED, a probability P of an edge (di, gj), between a selected gene node gj and a selected disease node di. The edge (di, gj) between the selected gene node gj and the selected disease node di is the disease-gene prioritization.

Abstract: Embodiments of the present disclosure describe a fingerprint contribution method for predicting a Gibbs free energy of biochemical reactions, methods of training a fingerprint contribution model for predicting a Gibbs free energy of biochemical reactions, methods of predicting a Gibbs free energy of biochemical reactions, a non-transitory computer readable medium comprising instructions which, when read by a computing device, cause a processor to execute a method for predicting a Gibbs free energy of biochemical reactions, and the like.

Abstract: A method for analysis of transcriptional aberrations and molecular diagnostic of genetic diseases includes receiving ribonucleic acid, RNA, related data; calculating a probability ?t of an error-free splicing for a coding transcript t based on the RNA data; calculating the count-per-million (CPM) normalized xt for the coding transcript t based on the RNA data; calculating an omega index based on a product of the probability ?t and the CPM normalized xt for a gene g of the human genome; and determining that the gene g is a candidate for a genetic disorder.

Abstract: A nozzle device for spinning comprising a nozzle, a polymer solution supply means that supplies a polymer solution to the nozzle and ejects the polymer solution from the nozzle tip, and a solvent vapor supply means that supplies a gas containing vapor of the same solvent as the solvent of the polymer solution at least to the vicinity of the polymer solution just ejected, and a spinning method using the nozzle device for spinning. Solidification of a spinning solution is prevented at the nozzle tip from which the spinning solution is ejected.

Abstract: The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.

Abstract: In aspects of the invention, a multilevel conversion circuit can include a configuration for linking capacitors, including diodes, reverse-blocking semiconductor switches, and resistors, and a circuit for clamping the capacitor voltage at a specified voltage. Such a configuration can serve to reduce the number of capacitors that need detection of the voltages thereof and appropriate changing-over operation of semiconductor switches to control the capacitor voltage to a desired value. By way of aspects of the invention, desired voltages can be provided to the capacitors.

Abstract: In aspects of the invention, a multilevel conversion circuit can include a configuration for linking capacitors, including diodes, reverse-blocking semiconductor switches, and resistors, and a circuit for clamping the capacitor voltage at a specified voltage. Such a configuration can serve to reduce the number of capacitors that need detection of the voltages thereof and appropriate changing-over operation of semiconductor switches to control the capacitor voltage to a desired value. By way of aspects of the invention, desired voltages can be provided to the capacitors.

Abstract: A novel technique to improve and extend endurance and reliability of a memory device utilizing multi-level cells is disclosed. As a memory device ages, it's reliability deteriorates. Prior to the memory device becoming completely unreliable, the memory device transitions from a multi-level cell operating mode to a reduced capacity operating mode. When operating in the multi-level cell mode, the memory system stores multiple bits per cell. The memory system stores fewer bits per cell when operating in the reduced capacity. The transition between modes is achieved by setting all bits of a particular memory page to a specific value, for example, either a logic “1” or a logic “0.

Abstract: A novel technique to improve and extend endurance and reliability of a memory device utilizing multi-level cells is disclosed. As a memory device ages, it's reliability deteriorates. Prior to the memory device becoming completely unreliable, the memory device transitions from a multi-level cell operating mode to a reduced capacity operating mode. When operating in the multi-level cell mode, the memory system stores multiple bits per cell. The memory system stores fewer bits per cell when operating in the reduced capacity. The transition between modes is achieved by setting all bits of a particular memory page to a specific value, for example, either a logic “1” or a logic “0.

Abstract: This invention relates to a process for purifying crystalline substances by charging the feed crystals containing impurities in a solid state to the top of a tower-type continuous crystallizer equipped with an agitating device, bringing said solid feed crystals into countercurrent contact with the melt formed by melting the descending crystals by a heating device provided in the lower section, taking out the purified crystals as melt from the lower section, and taking out the mother liquor containing the concentrated impurities from the upper section and comprises maintaining the temperature of the mother liquor existing in the upper section in a specified range by either heating the feed crystals or the upper section of the continuous crystallizer or making the average particle diameter of the feed crystals 2.5 mm or more.

Abstract: This invention relates to a process for purifying benzoic acid continuously to a purity of 99.9% or more by introducing crystals of crude benzoic acid with a bulk density of 0.2 g/cm3 or more and an average particle diameter of 0.3 mm or more into a continuous crystallization apparatus equipped with a stirrer and a heating device from the upper portion of the apparatus, effecting counter-current contact of the falling crystals of crude benzoic acid with the melt generated by heating with the heating device, withdrawing the purified benzoic acid as melt from the lower portion of the apparatus, and withdrawing the mother liquor from the upper portion of the apparatus. The process makes it possible to prepare high-purity benzoic acid continuously in a relatively simple apparatus at high efficiency.

Abstract: A chain belt for stepless speed change transmission is provided wherein the connecting link rocker pins are arranged so that when the chain links are rotated relative to each other the pitch changes. This phenomena is used to reduce the drive noise generated with standard types of chain belts when they wrap around the drive pulley, due to a change in the relative speed of the drive block. From tests it is found that having the drive blocks outside of the chain line is more effective in reducing this relative velocity. Further having oval shaped drive blocks reduces the stress concentration at the region where load is transferred from the pulley to the chain belt, and by having an oval shape instead of a round shape the inclined end contact faces can be positively aligned to mate properly with the drive faces of the pulleys.

Abstract: This invention relates to a vacuum seasoning device, which is compact in size and simple in structure, and comprises a main body casing which contains a vacuum pump mechanism consisting of a piston, cylinder, and the like arranged horizontally; and said main body is so rotatably supported by a support column that it can transpose itself from a horizontal position to a position where its front portion is slightly raised; and when it is positioned horizontally the base plate of the same hermetically contacts the upper opening edge of the pressure container placed below it, and sucks the air out of the container by means of the horizontal reciprocating movement of the piston, and vent through suction port arranged on the base plate, suction channel of aforementioned vacuum pump mechanism, and then through communicating section thereof.