Patents by Inventor Hiroyuki Miyagi

Hiroyuki Miyagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5294336
    Abstract: Stable hemoglobin ( can be separated from other hemoglobin components and quantitated in a short time by means of a liquid-chromatographic apparatus comprising a separation column packed with a packing material consisting essentially of a porous substance having a carboxyalkyl group combined thereinto, as ion exchanger, a means for injecting a sample into the separation column, a means for passing one or more eluents through the separation column, and a means for detecting hemoglobin, hemoglobin derivatives or glycosylated hemoglobin, the average particle size of the packing material in dry state being 4 .mu.m or less.
    Type: Grant
    Filed: June 9, 1992
    Date of Patent: March 15, 1994
    Assignee: Hitachi, Ltd.
    Inventors: Masako Mizuno, Kenji Tochigi, Yutaka Misawa, Hiroyuki Miyagi, Yoshio Watanabe, Taro Nogami, Junkichi Miura, Yoshinori Takata
  • Patent number: 5132012
    Abstract: A liquid chromatograph comprises an analyzing chip in which a capillary is formed in a substrate and a detector section is disposed downstream of the capillary. The capillary is covered so that an inlet opening end and an outlet opening end of said capillary flow path is opened. A frame member has a sample introduction path, a carrier liquid introduction path and a liquid discharge path. The analyzing chip is movably disposed in the frame member so that the inlet opening end and the outlet opening end of the capillary are selectively in communication with and/or under interruption against said sample introduction path, the carrier liquid introduction path and the liquid discharge path. The liquid chromatograph is very small in size but is easy to handle. Incidentally, there is disclosed also a sample introduction apparatus and method for the chromatograph, and an FET type detector suitable for the chromatograph.
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: July 21, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Junkichi Miura, Andreas Manz, Yoshio Watanabe, Yuji Miyahara, Hiroyuki Miyagi, Keiji Tsukada
  • Patent number: 5116481
    Abstract: An anion-selective electrode of the present invention comprises, as anion sensitive substance, a tetraalkyl type, quaternary phosphonium salt having four alkyl radicals, each having 8 to 24 carbon atoms; a combination of a tetraalkyl onium salt having four alkyl radicals each having 10 to 24 carbon atoms, and an onium salt having one alkyl radical with 1 to 20 carbon atoms and three alkyl radicals with the proviso that the number of carbon atoms contained in the three alkyl radicals each is larger than that contained in the one alkyl radical; or a tetraalkyl type, quaternary onium salt having an asymmetrical molecular structure. The anion-selective electrode has good properties including selectivity and measurement accuracy. An anion-selective, field effect transistor or a chemical analysis apparatus, provided with the anion-selective sensitive substance, is suitable for measuring an anion concentration with a high accuracy.
    Type: Grant
    Filed: April 5, 1990
    Date of Patent: May 26, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Satoshi Ozawa, Naoto Oki, Yasuhisa Shibata, Hiroyuki Miyagi
  • Patent number: 5112471
    Abstract: The present invention provides an ion selective electrode for anions such as Cl.sup.- and cations such as Ca.sup.2+ which has a sensitive membrane comprising a polymer material and containing an ion sensitive material and a plasticizer. In thins ion selective electrode, the ion sensitive material is an ion exchanger such as a quaternary ammonium salt, a quaternary phosphonium salt or an organic phosphate and the plasticizer is a compound having the formula (1): ##STR1## wherein X represents an alkyl group, a phenyl group or a phenyl group to which a functional group bonds. As the plasticizer there may also be used a mixture of the compound of the formula (1) with an alcohol compound such as an alcohol having a dielectric constant of 10 or less and containing 10 or more carbon atoms or an ester compound.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: May 12, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Yasuhisa Shibata, Naoto Oki, Satoshi Ozawa, Hiroyuki Miyagi
  • Patent number: 5102525
    Abstract: A planar oxygen sensor has an insulating substrate, a cathode formed on the insulating substrate generally at the center thereof; another electrode formed on the insulating substrate in a region other than the region of the cathode, a gas permeable membrane stretched to cover these electrodes and having its peripheral portion supported on the insulating substrate, and an electrolytic solution charged between the gas permeable membrane and the insulating substrate. A surface of the cathode is substantially in contact with the gas permeable membrane and is formed at a position higher than the gas permeable membrane support portion of the insulating substrate. A portion of the insulating substrate surface other than the region where the cathode is formed is recessed. Because the layer of electrolytic solution on the cathode is thin, oxygen molecules passing through the gas permeable membrane can immediately serve for the reduction at the cathode, thereby increasing the response speed of the planar oxygen sensor.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: April 7, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Yuji Miyahara, Keiji Tsukada, Yasuhisa Shibata, Hiroyuki Miyagi
  • Patent number: 5093267
    Abstract: Catecholamines can be detected with high sensitivity in a shortened time period, by introducing a sample containing catecholamines into an adsorption column packed with an adsorbent to adsorb catecholamines to the column, then introducing a reagent for derivatization to effect pre-column labeling and then analyzing the pre-column labeled catecholamines by means of high performance liquid chromatography. Connection of the adsorption column and a separation column of high performance liquid chromatography via a fluid path changeover valve enables to automated analysis of catecholamines.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: March 3, 1992
    Assignee: Hitachi, Ltd.
    Inventors: Junkichi Miura, Mamoru Taki, Yoshio Watanabe, Masao Kamahori, Hiroyuki Miyagi
  • Patent number: 5005434
    Abstract: An autosampler consists of a needle to draw specimen from a specimen container into a passage therein; a block having a passage that follows the passge in the needle; a suction mechanism for drawing in the specimen by suction through the passages in the needle and the block; a discharge mechanism for discarding the specimen drawn in by the suction mechanism; and a detecting device for detecting air bubble in the specimen, the detecting device being embedded in the block in such a manner as to face the passage in the block. The detecting device detects the air bubbles in the specimen according to changes in physical or chemical properties of the specimen passing through the passage in the block. The discharge mechanism is activated by the detecting device to discharge air-mixed specimen.
    Type: Grant
    Filed: August 8, 1989
    Date of Patent: April 9, 1991
    Assignee: Hitachi, Ltd.
    Inventors: Yoshio Watanabe, Mamoru Taki, Junkichi Miura, Masao Kamahori, Hiroyuki Miyagi, Yasuhide Matsumura, Masafumi Kanetomo
  • Patent number: 4936975
    Abstract: A liquid film type, chloride ion-selective electrode is provided with the present invention, which comprises a sensitive film containing a polymeric material as a support film material, a tetraalkyl ammonium salt with four alkyl group each having 10-24 carbon atoms as a chloride ion-sensitive substance, and a mixture of a linear alcohol having a low dielectric constant with at leastg 10 carbon atoms and an organic compound having a dielectric constant higher than that of said linear alcohol as plasticizer. This electrode has a high selectivity over lipophilic anions and hydrophilic anions, high accuracy ion measurements, and a long life.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: June 26, 1990
    Assignee: Hitachi, Ltd.
    Inventors: Yasuhisa Shibata, Satoshi Ozawa, Naoto Oki, Hiroyuki Miyagi
  • Patent number: 4823168
    Abstract: A flow cell for a photometer, which comprises a cell body integrated from a pair of cell body members by joining, at least one of which is provided with a linear groove on the joining surface of the cell body member from one end to another to the full length, as exposed to the joining surface, the groove playing both roles of a liquid sample passage and a detecting light path by the integration of the cell body members, and is further provided with a liquid sample inlet passage at a position near one end of the groove and a liquid sample outlet passage at a position near the other end of the groove, both passages being communicated with the grooves, the linear groove being provided with a light reflecting layer to the full length of the linear groove, and a pair of light transmission window members joined with the flow cell body at both ends on the groove-open sides thereof is provided, where polishing of the grooves is readily carried out and random reflection of light or absorption of light due to poor refl
    Type: Grant
    Filed: November 4, 1987
    Date of Patent: April 18, 1989
    Assignee: Hitachi, Ltd.
    Inventors: Masao Kamahori, Yoshio Watanabe, Junkichi Miura, Mamoru Taki, Hiroyuki Miyagi
  • Patent number: 4452682
    Abstract: An apparatus for electrochemically measuring clinical emergency check items of blood for a short time by flowthrough system, using a small amount of whole blood as a blood sample, which comprises a blood pH/gas component sensor unit, an electrolyte component sensor unit, and/or a biochemical component sensor unit, arranged in series in this order, a sampler and these sensor units being communicated with one another through a blood sample flow passage or channel, each of the sensor units being provided with sensor electrodes and at least one reference electrode as electrochemical sensor means.Detected values from each of the sensor units are transmitted to a computer or calculator through a current amplifier and/or a differential amplifier for a differential voltage from the voltage of the reference electrode to compute pH, pressure, or concentrations from the detected values, and numerically displayed on a display device connected to the computer.
    Type: Grant
    Filed: October 24, 1980
    Date of Patent: June 5, 1984
    Assignee: Hitachi, Ltd.
    Inventors: Yoshinori Takata, Hiroyuki Miyagi, Kunio Hirota, Yasuhisa Shibata, Kazuo Nidaira, Fusao Shirato
  • Patent number: 4338811
    Abstract: A disease diagnostic method and apparatus in which a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram of substances in a body fluid of a subject is obtained to be geographically compared, for disease diagnostic purpose, with a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram obtained through separating and detecting substances in a body fluid of a normal person, and also with two-dimensional pattern diagrams representing the relation between integrated values of peaks and the retention times in chromatograms obtained through separating and detecting substances in a body fluid of abnormal patients classified by diseases.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: July 13, 1982
    Assignee: Hitachi, Ltd.
    Inventors: Hiroyuki Miyagi, Yoshinori Takata, Junkichi Miura, Mamoru Taki
  • Patent number: 4112297
    Abstract: A new interface is interposed between a liquid chromatograph and a mass spectrometer, and it consists of a nebulizer, an evaporator and a cooler. An effluent from the liquid chromatograph is nebulized by the nebulizer. The nebulized effluent is heated by the evaporator, and has only its solvent evaporated. A mixed fluid which consists of the evaporated solvent and the nebulized sample is guided to the cooler, and is cooled therein. At this time, the evaporated solvent is condensed again and is separated from the nebulized sample as a liquid. The nebulized sample left behind is guided to an ion source of the mass spectrometer.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: September 5, 1978
    Assignee: Hitachi, Ltd.
    Inventors: Hiroyuki Miyagi, Fumito Nakajima, Yoshijiro Arikawa