Abstract: The present disclosure provides a technique for introducing an antigen receptor-encoding nucleic acid into a definite site in a nucleic acid that is contained in an immune cell of a target organism. In the technique according to the present disclosure, a vector, which contains an antigen receptor-encoding nucleic acid, and a nuclease are introduced into an immune cell. The nuclease cleaves the vector and the genome sequence of the immune cell. The vector can be configured so that, when cleaved with the nuclease, a sequence, which is an antigen receptor-encoding sequence and which is introduced by microhomology-mediated end-joining (MMEJ) at the nuclease cleavage site of the genome sequence of the immune cell, is formed.

Abstract: A method for producing a fluoropolymer which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer, the surfactant being represented by the general formula (1): CR1R2R4—CR3R5—X-A, wherein R1 to R5 are each H or a monovalent substituent, with the proviso that at least one of R1 and R3 represents a group represented by the general formula: —Y—R6 and at least one of R2 and R3 represents a group represented by the general formula: —X-A or a group represented by the general formula: —Y—R6; and A is the same or different at each occurrence and is —COOM, —SO3M, or —OSO3M. Also disclosed is a surfactant for polymerization represented by the general formula (1), a method for producing a fluoropolymer using the surfactant, a composition including a fluoropolymer and the surfactant and a molded body including the composition.

Abstract: A fixing device includes a belt having a tubular shape and extending in a longitudinal direction, and having a longitudinal end, a drive roller to rotate the belt to convey a print medium between the drive roller and the belt, a bushing located at the longitudinal end of the belt, and a guide wall adjacent to the bushing. The belt is displaceable in the longitudinal direction relative to the bushing. The bushing includes a shoulder adjacent to the longitudinal end of the belt and a stem extending from the shoulder to an inside of the belt to support the belt. The guide guides the bushing to move in a direction opposite to a conveyance direction of the print medium when the belt moves toward the bushing. The stem of the bushing includes a convex portion that is in contact with an inner surface of the belt when the belt is displaced in the longitudinal direction.

Abstract: The present invention proposes a program production method or the like that is suitable for generating a program according to a change in situation. In a program production apparatus 3, a program production unit 21 generates a program using material data. A basic script storage unit 11 stores a basic script. In a stage in which the generation of the program is started, the program production unit 21 generates the program according to the basic script. Subsequently, the program production unit 21 gradually modifies the basic script using dynamic data (e.g., a user's instruction, information collected in a real-time manner, etc.), so as to generate a program suitable for the situation of the material data, viewers, or the like. This enables the provision of even live broadcasting with a small number of users. Also, this allows emergency broadcasting to be automatically provided according to situation.

Abstract: A fiber optic adapter for use with a fiber optic connector is provided. The fiber optic adapter indicates during installation of the connector when the connector is properly installed in the fiber optic adapter. The adapter includes a housing with a cavity at one end for receiving the fiber optic connector. The housing contains a sliding latch configured to contact the fiber optic connector when the fiber optic connector is inserted into the cavity. The sliding latch is movable within the housing from an extended position to a latched position. A connector latch in the housing is configured to engage the stop when the sliding latch is at the latched position. A spring is coupled to the sliding latch and is compressible during insertion of the fiber optic connector into the cavity. When the fiber optic connector is inserted into the cavity, the fiber optic adapter indicates when the sliding latch is not at the latched position.

Abstract: A method for producing a fluoropolymer which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer, the surfactant being represented by the general formula (1): CR1R2R4—CR3R5—X-A, wherein R1 to R5 are each H or a monovalent substituent, with the proviso that at least one of R1 and R3 represents a group represented by the general formula: —Y—R6 and at least one of R2 and R5 represents a group represented by the general formula: —X-A or a group represented by the general formula: —Y—R6; and A is the same or different at each occurrence and is —COOM, —SO3M, or —OSO3M. Also disclosed is a surfactant for polymerization represented by the general formula (1), a method for producing a fluoropolymer using the surfactant and a composition including a fluoropolymer and the surfactant.

Abstract: A composition including a fluoropolymer and substantially free from a compound represented by the following formula (3): (H—(CF2)8—SO3)qM2, wherein M2 is H, a metal atom, NR54, imidazolium optionally containing a substituent, pyridinium optionally containing a substituent, or phosphonium optionally containing a substituent; R5s are each H or an organic group and are the same as or different from each other; and q is 1 or 2.

Abstract: A non-transitory computer-readable storage medium storing a search program that causes at least one computer to execute a process, the process includes searching for, as an answer of a combinatorial optimization problem, a first arrangement of a plurality of amino acids included in a medium molecule based on a value of a first cost arithmetic expression that does not make distinction between a L-form and a D-form of the plurality of amino acids; searching for, as the answer of the combinatorial optimization problem, a second arrangement of the plurality of amino acids based on a value of a second cost arithmetic expression that makes distinction between the L-form and the D-form of the plurality of amino acids by setting the first arrangement as an initial arrangement of searching; and outputting the second arrangement.

Abstract: Disclosed is a patch for alleviating cancerous pain. The patch is provided with a support layer and an adhesive layer laminated on the support layer. The adhesive layer contains an adhesive base and 150-225 mg of diclofenac sodium. One patch is used by being attached once per day.

Abstract: The present invention provides a patch for relieving lumbago, the patch comprising a backing and an adhesive layer laminated on the backing, wherein the adhesive layer comprises an adhesive base and 0.70 to 1.50 mg of diclofenac sodium per cm2 of application area, and the patch is used by applying the patch once a day to the chest region, the abdominal region, the dorsal region, the brachial region, or the femoral region of a human.

Abstract: Disclosed is a patch for relieving cancer pain, the patch comprising a support layer, and an adhesive layer laminated on the support layer, wherein the adhesive layer contains an adhesive base and diclofenac sodium. The patch is applied once a day, and is used such that the dosage of the diclofenac sodium is 150-225 mg per dose.

Abstract: According to an aspect of the present disclosure, a substrate state determining apparatus includes: an image capturing unit that captures an image of a substrate placed on a stage; a learning unit that executes a machine learning using training data in which information indicating a state of the substrate is attached to the image of the substrate, so as to generate a substrate state determination model in which the image of the substrate is taken as an input and a value related to the state of the substrate corresponding to the image of the substrate is taken as an output; and a determination unit that determines the state of the substrate corresponding to the image of the substrate captured by the image capturing unit, using the substrate state determination model generated by the learning unit.

Abstract: An image forming apparatus includes a lubricant application target member, an application roller which is provided at a position adjacent to the lubricant application target member to apply a lubricant to the lubricant application target member, a lubricant support member which supports the lubricant, and a movement mechanism which includes a guide coupled to the lubricant support member and extending along a linear direction. An engaging portion engages with the guide and restricts movement of the lubricant support member in a linear direction of the guide by engagement of the guide with the engaging portion.

Abstract: A stable structure search system includes one or more processors configured to acquire a plurality of degrees of structure similarity between each of a plurality of kinds of molecules and a first molecule included in a target molecule based on each interaction potential of the plurality of kinds of molecules, acquire a plurality of degrees of charge similarity between each of the plurality of kinds of molecules and the first molecule, acquire a plurality of total degrees of similarity based on sums of each of the plurality of degrees of structure similarity and each of the plurality of degrees of charge similarity, determine a second molecule whose total degree of similarly is largest among the plurality of kinds of molecules, acquire energy of a molecular structure of the target molecule based on an interaction potential of the second molecule, and determine whether the calculated energy satisfies a certain condition.

Abstract: A method for producing a fluoropolymer of the invention which includes polymerizing a fluoromonomer in an aqueous medium in the presence of a surfactant to provide a fluoropolymer. The surfactant includes at least one selected from the group consisting of a surfactant represented by R1a—CO—R2a—CO—R3a-Aa and a surfactant represented by R1b—CO—(CR2b2)n—(OR3b)p—(CR4b2)q-L-Ab.

Abstract: An image forming apparatus includes a transfer device to transfer an unfixed toner image to a print medium, a fixing device located along a conveyance path of the print medium, and a gloss applying device. The unfixed toner image includes clear toner that is associated with a gloss image to be formed. The gloss applying device receives the print medium including the unfixed toner image, to fix the unfixed toner image to the print medium by applying heat and pressure, and to cool the heated toner image to form the gloss image.

Abstract: A method for producing a fluoropolymer powder including (A1) adding, to a fluoropolymer aqueous dispersion obtained by polymerization using a carboxylic acid type hydrocarbon surfactant, and an acid to adjust a pH to 4.0 or less and cause coagulation to thereby obtain a wet fluoropolymer powder containing a fluorine-containing compound represented by the following general formula (1A), and (B1) heat-treating the wet fluoropolymer powder at a temperature higher than 150° C. and lower than 240° C.: General Formula (1A): H—(CF2)m—COOH wherein m is 3 to 19.

Abstract: A fuel cell system includes a fuel cell that generates power using a fuel gas and an oxygen-containing gas, a reformer including a vaporizing section and a reforming section, a raw fuel supply that supplies raw fuel, a reformed water supply that supplies reformed water, and a controller. The controller has multiple calculation formulas for calculating an amount of reformed water to be used in the reforming section in response to a requested power level from an external unit, and selects, based on an increase or a decrease in a requested current level from the external unit, a formula from the multiple calculation formulas in response to the increase in the requested current level, and a formula different from the formula to be selected for the increase from the multiple calculation formulas in response to the decrease in the requested current level.

Abstract: The present invention proposes a program production method or the like that is suitable for generating a program according to a change in situation. In a program production apparatus 3, a program production unit 21 generates a program using material data. A basic script storage unit 11 stores a basic script. In a stage in which the generation of the program is started, the program production unit 21 generates the program according to the basic script. Subsequently, the program production unit 21 gradually modifies the basic script using dynamic data (e.g., a user's instruction, information collected in a real-time manner, etc.), so as to generate a program suitable for the situation of the material data, viewers, or the like. This enables the provision of even live broadcasting with a small number of users. Also, this allows emergency broadcasting to be automatically provided according to situation.

Abstract: Provided is a method for producing a fluoropolymer, including a polymerization step of polymerizing a fluoromonomer in an aqueous medium having a pH of 4.0 or more in the presence of a hydrocarbon surfactant and a polymerization initiator to obtain a fluoropolymer.