Patents by Inventor Hiroyuki Satofuka

Hiroyuki Satofuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190322732
    Abstract: An object of the present invention is to provide an antibody against VEGF that inhibits binding of a vascular endothelial growth factor (VEGF) to neuropilin-1 (NRP1). The present invention provides an antibody against VEGF that inhibits binding of VEGF to NRP1.
    Type: Application
    Filed: January 5, 2017
    Publication date: October 24, 2019
    Applicants: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi MURAKAMI, Hiroyuki SATOFUKA, Shigeki MUKOUBATA, Hirotada AKIYAMA, Tatsuji KUROSE, Sae AKAO
  • Publication number: 20190127461
    Abstract: The present invention aims to provide a cancer-specific new pharmaceutical composition with fewer side effects. The present invention provides a pharmaceutical composition comprising a monoclonal antibody recognizing a polypeptide of an extracellular region of native MCT5.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 2, 2019
    Applicant: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki SATOFUKA, Youko OKABE, Dai KATO
  • Patent number: 10214584
    Abstract: The present invention aims to provide a pharmaceutical composition for cancer treatment, which comprises a novel monoclonal antibody binding to SLC6A6 or its extracellular region and a chemotherapeutic agent conjugated therewith, as well as a therapeutic method in which the monoclonal antibody or a therapeutic agent composed of the monoclonal antibody conjugated with a chemotherapeutic agent is used in combination with a chemotherapeutic agent. The present invention provides a pharmaceutical composition comprising an antibody conjugate configured such that a monoclonal antibody having higher affinity than conventional antibodies and recognizing native SLC6A6 or a native polypeptide of an extracellular region of SLC6A6 is conjugated with an anticancer agent or the like having activity against cancer and other hyperproliferative diseases.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: February 26, 2019
    Assignee: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki Satofuka, Kensuke Ohse, Shigeki Mukobata, Hirotada Akiyama, Masaya Ohtsu, Yoko Okabe, Yasufumi Murakami
  • Publication number: 20170313770
    Abstract: The present invention provides a reagent for detection or diagnosis of cancer, which comprises a monoclonal antibody against MCT5 or a fragment thereof.
    Type: Application
    Filed: October 1, 2015
    Publication date: November 2, 2017
    Applicant: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki SATOFUKA, Yoko OKABE
  • Publication number: 20160333092
    Abstract: The present invention aims to provide a pharmaceutical composition for cancer treatment, which comprises a novel monoclonal antibody binding to SLC6A6 or its extracellular region and a chemotherapeutic agent conjugated therewith, as well as a therapeutic method in which the monoclonal antibody or a therapeutic agent composed of the monoclonal antibody conjugated with a chemotherapeutic agent is used in combination with a chemotherapeutic agent. The present invention provides a pharmaceutical composition comprising an antibody conjugate configured such that a monoclonal antibody having higher affinity than conventional antibodies and recognizing native SLC6A6 or a native polypeptide of an extracellular region of SLC6A6 is conjugated with an anticancer agent or the like having activity against cancer and other hyperproliferative diseases.
    Type: Application
    Filed: January 15, 2015
    Publication date: November 17, 2016
    Applicant: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki SATOFUKA, Kensuke OHSE, Shigeki MUKOBATA, Hirotada AKIYAMA, Masaya OHTSU, Yoko OKABE, Yasufumi MURAKAMI
  • Publication number: 20160116478
    Abstract: The object of the present invention is to provide a reagent for detection or diagnosis of cancer. The present invention provides a reagent for detection or diagnosis of cancer, which comprises a monoclonal antibody against LGR6 or a fragment of the antibody.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 28, 2016
    Applicant: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki SATOFUKA, Yasufumi MURAKAMI
  • Publication number: 20160009799
    Abstract: The object of the present invention is to prepare a cancer therapeutic agent by means of a novel monoclonal antibody which binds to SLC6A6 or its extracellular region and a substance which suppresses SLC6A6 expression. The present invention provides a pharmaceutical composition comprising a monoclonal antibody which recognizes native SLC6A6 or a polypeptide in the extracellular region of SLC6A6.
    Type: Application
    Filed: March 6, 2013
    Publication date: January 14, 2016
    Applicant: ORDER-MADE MEDICAL RESEARCH INC.
    Inventors: Hiroyuki SATOFUKA, Kensuke OHSE, Shigeki MUKOBATA, Yumiko KATO, Yoko OKABE, Yasuhiro MATSUMURA, Masahiro YASUNAGA
  • Patent number: 8598408
    Abstract: The present invention aims to provide a method for antibody preparation. The present invention is directed to a method for preparing an antibody-producing cell, which comprises the following steps: (1) transplanting metastatic cancer cells capable of expressing a target antigen into a non-human animal to ensure engraftment of the cancer cells in the animal; (2) immunizing the animal with the target antigen; and (3) collecting the antibody-producing cell from the immunized animal; as well as a method for preparing an antibody, which comprises collecting the antibody from the antibody-producing cell prepared by the above method.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: December 3, 2013
    Assignee: Ordermade Medical Research Inc.
    Inventors: Hiroyuki Satofuka, Masahiro Uchino, Shingo Hanaoka
  • Publication number: 20130230869
    Abstract: The purpose of the present invention is to provide a novel monoclonal antibody which binds to SLC6A6 or an extracellular domain thereof. The present invention relates to a monoclonal antibody which recognizes native SLC6A6 or a polypeptide of an extracellular domain of SLC6A6.
    Type: Application
    Filed: September 1, 2011
    Publication date: September 5, 2013
    Applicants: NATIONAL CANCER CENTER, BIO MATRIX RESEARCH, INC.
    Inventors: Hiroyuki Satofuka, Youko Okabe, Yasuhiro Matsumura, Masahiro Yasunaga
  • Publication number: 20120151611
    Abstract: The present invention aims to provide a method for antibody preparation. The present invention is directed to a method for preparing an antibody-producing cell, which comprises the following steps: (1) transplanting metastatic cancer cells capable of expressing a target antigen into a non-human animal to ensure engraftment of the cancer cells in the animal; (2) immunizing the animal with the target antigen; and (3) collecting the antibody-producing cell from the immunized animal; as well as a method for preparing an antibody, which comprises collecting the antibody from the antibody-producing cell prepared by the above method.
    Type: Application
    Filed: August 24, 2011
    Publication date: June 14, 2012
    Inventors: Hiroyuki Satofuka, Masahiro Uchino, Shingo Hanaoka
  • Publication number: 20110318387
    Abstract: The object of the present invention is to provide an immunization method which allows efficient preparation of a desired antibody. The present invention provides a method for immunizing a laboratory animal, which comprises the following steps: (1) transplanting cancer cells having a metastatic potential and capable of expressing an antigen into the laboratory animal; and (2) allowing the cancer cells to be engrafted in the laboratory animal to thereby immunize the laboratory animal.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 29, 2011
    Inventors: Hiroyuki Satofuka, Masahiro Uchino, Hiroko Kojima