Abstract: The present invention provides a non-coating topical therapeutic agent for tinea unguium containing medium-chain triglyceride and the like as non-volatile components, which agent has high nail permeability and is superior in the aspects of efficacy and preparation properties, and can be applied clinically. Particularly, the present invention provides a topical therapeutic agent for tinea unguium containing an antifungal active substance such as efinaconazole or the like, a volatile component, an additive such as medium-chain triglyceride or the like, and a permeation enhancer such as ethyl lactate and the like. The preparation shows remarkably improved nail permeability has superior properties as a pharmaceutical product from the aspects of efficacy and preparation properties.

Abstract: Pharmaceutical compositions for improving the solubility and dissolution of poorly soluble drugs which contain a therapeutic agent, a pharmaceutically acceptable polymer, and a spontaneously emulsifying component are described herein. These pharmaceutical compositions have been prepared by thermal processes to obtain a composition which shows improved properties including improved solubility of the therapeutic agent above the amount of therapeutic agent which should be soluble in either the spontaneously emulsifying component or the pharmaceutically acceptable polymer. Also provided herein are methods of preparing and use thereof.