Patents by Inventor Hiroyuki Yokote

Hiroyuki Yokote has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing live smallpox vaccine
    Patent number: 8030020
    Abstract: A safer live smallpox vaccine, which contains a lowered content of revertants, is provided. A process for manufacturing a live smallpox vaccine which comprises steps of: inoculating a master seed solution of an attenuated vaccinia virus to an appropriate number of containers (1 to n wherein n is an integer) of rabbit kidney cells and incubating them; inoculating a portion of the cultured solution obtained from each container to RK-13 cells and to Vero E6 cells and incubating them to thereby select containers which contain a cultured solution that forms plaques in RK-13 cells but not in Vero E6 cells; and preparing a drug substance of vaccine using the aforementioned cultured solution (working seed solution), and a live smallpox vaccine prepared in the aforementioned process.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: October 4, 2011
    Assignees: Juridicial Foundation The Chemo-Sero-Therapeutic Research Institute, Japan as represented by Director General of National Institute of Infectious Diseases
    Inventors: Tomomi Kanehara, Hiroyuki Yokote, Kunio Ohkuma, Masahiko Kuranaga, Shigeru Morikawa
  • PROCESS FOR PREPARING LIVE SMALLPOX VACCINE
    Publication number: 20100183672
    Abstract: A safer live smallpox vaccine, which contains a lowered content of revertants, is provided. A process for manufacturing a live smallpox vaccine which comprises steps of: inoculating a master seed solution of an attenuated vaccinia virus to an appropriate number of containers (1 to n wherein n is an integer) of rabbit kidney cells and incubating them; inoculating a portion of the cultured solution obtained from each container to RK-13 cells and to Vero E6 cells and incubating them to thereby select containers which contain a cultured solution that forms plaques in RK-13 cells but not in Vero E6 cells; and preparing a drug substance of vaccine using the aforementioned cultured solution (working seed solution), and a live smallpox vaccine prepared in the aforementioned process.
    Type: Application
    Filed: August 6, 2007
    Publication date: July 22, 2010
    Applicants: Juridical Foundation the Chemosero-Therapeutic Research Institute, Japan as represented by Director General of National Institute of Infectious Diseases
    Inventors: Tomomi Kanehara, Hiroyuki Yokote, Kunio Ohkuma, Masahiko Kuranaga, Shigeru Morikawa
  • Method for converting multimers of human serum albumin into monomers thereof
    Publication number: 20030027991
    Abstract: A method for converting a multimer of human serum albumin into monomers thereof comprises the step of treating the multimer with an alkaline solution. This method permits the efficient and quite simple conversion of human serum albumin multimers into monomers thereof at a low cost.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 6, 2003
    Applicant: Juridical Fdn. The Chemo-Sero-Therap. Res. Ctr.
    Inventors: Toshinobu Nouchi, Hiroshi Mizokami, Yoshitaka Tajima, Hiroyuki Yokote, Satoshi Adachi, Yoshinobu Miyatsu, Tetsuro Tanabe, Yoshitaka Ushio, Shinichi Shibata
  • Silicon carbide substrate for forming magnetic head
    Patent number: 6437943
    Abstract: To provide a magnetic-head substrate capable of improving the heat radiation characteristic while keeping a mechanical strength and a milling characteristic equal to those of a conventional Al2O3-TiC system and preventing an device from contacting a medium face and moreover superior in film contact strength, electrical withstand voltage, and face quality. The magnetic-head substrate is constituted of a sintered body containing 99 wt % or more of silicon carbide and 0.3 wt % or less of free carbon and having a relative density of 99% or more.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: August 20, 2002
    Assignee: Kyocera Corporation
    Inventors: Hiroyuki Yokote, Tatsuya Kimura