Abstract: Provided is a composition comprising an RNAi molecule which suppresses expression of CHST15 gene and successfully used for less invasive administration.

Abstract: A protection membrane-forming film (1) containing a filler, wherein the average particle size of the filler is not more than 0.4 ?m, a protection membrane-forming sheet (2), a production method and an inspection method for a workpiece or a processed product which use the film and the sheet, and a workpiece and a processed product determined as adequate products by the inspection method. The protection membrane-forming film and the protection membrane-forming sheet of the invention enable the formation of a protection membrane having excellent print legibility when subjected to print processing by laser irradiation.

Abstract: An optical film includes a base material film including a (meth)acrylic resin and a first cured layer obtained by curing a first composition including a curable compound, in which the first cured layer is formed of a compatible layer and a first hardcoat layer, the compatible layer and the first hardcoat layer are provided in this order from the base material film side, and a pencil hardness of a surface of the optical film on the first cured layer side is H or more, and a peak intensity value of a power spectrum obtained by means of Fourier transformation of a reflectivity spectrum measured from the first cured layer side of the optical film by means of an optical interference-type non-contact surface shape measurement is 0.001 to 0.030. A method for manufacturing an optical film and an image display device includes the optical film.

Abstract: A protective film-forming composite sheet 10 comprises a pressure sensitive adhesive sheet 16 in which a pressure sensitive adhesive layer 12 is provided on a base material 11, a protective film-forming film 13, and a release film 14. When ? (mN/25 mm) represents the maximum peel force between the protective film-forming film 13 and the release film 14; ? (mN/25 mm) represents the minimum peel force between the pressure sensitive adhesive sheet 16 and the protective film-forming film 13; and ? (mN/25 mm) represents the maximum peel force between the pressure sensitive adhesive sheet 16 and the protective film-forming film 13, the following relationships (1) to (3) hold for ?, ?, and ?; ??70??(1) ?/??0.50??(2) ??2000??(3).

Abstract: Provided is protective film-forming sheet (2) including: a protective film-forming film (1) having a light transmittance at a wavelength of 1064 nm of 55% or greater and a light transmittance at a wavelength of 550 nm of 20% or less; and a release sheet (21) which is laminated on one or both faces of the protective film-forming film (1). According to this protective film-forming sheet (2), it is possible to form a protective film which allows a workpiece such as a semiconductor wafer to have a modified layer disposed in advance therein by a laser so that the workpiece can be split through the application of force thereon, while preventing grinding marks on the workpiece or a product formed therefrom from being visible to the naked eye.

Abstract: A controller is configured to determine a current gear ratio step determined on the basis of gear ratio calculation Rg to be actual gear ratio of revolution Nm of main shaft 3a and revolution Nc of counter shaft 3b as well as gear ratio map for defining gear ratio variable allowance range for each of gear ratio steps. When making a decision of status of the determined current gear ratio step, the controller is configured to make delay timer get started when the gear ratio calculation Rg goes within the gear ratio variable allowance range of next step and halt to make a decision of the current gear ratio step while the delay timer is activated. The controller is also configured to make a decision of the status of the current gear ratio step after a predetermined delayed time Tn*(n=1, 2, . . . ) is elapsed.

Abstract: A wavelength conversion member is provided. The wavelength conversion member includes: a wavelength conversion layer including at least one kind of quantum dots that are excited by excitation light to emit fluorescence and an antioxidant; at least one interposing layer that is formed to be adjacent to the wavelength conversion layer; and a barrier layer that is formed on at least one surface of the wavelength conversion layer, in which at least one layer of the interposing layers is an antioxidant-containing interposing layer including the antioxidant.

Abstract: A composition for protective film formation capable of forming a protective film excellent in attachability by a tape mounter or the like, with good visibility at a laser-printed portion and heat dissipation properties, allowing a protective film-equipped chip having high reliability to be manufactured, and a sheet for protective film formation and a protective film-equipped chip are provided. The composition for protective film formation contains a polymer component (A), a curable component (B), and a heat conductive filler (C) having an average particle size of 2.0 to 10.0 ?m. The content of components that are liquid at 25° C. contained in the composition for protective film formation is 20 to 70 parts by mass relative to 100 parts by mass of the total of the (A) component and the (B) component.

Abstract: The backlight unit includes a light source unit, and a wavelength conversion member disposed on an optical path of light emitted from the light source unit. The light source unit includes a light source allocated to each of the areas, a control of the backlight brightness for each area is performed by controlling a light emission intensity of each light source allocated to each area independently of a light emission intensity of a light source allocated to a different area, and a light source allocated to at least one area includes a light source group including two or more kinds of light sources having different light emission maximum wavelengths, and a light emission intensity of at least one kind of light source included in the light source group is capable of being controlled independently of a light emission intensity of a different light source included in the light source group.

Abstract: A wavelength conversion member, is provided with a wavelength conversion layer that includes quantum dots and is interposed between two barrier layers. The wavelength conversion member includes a light scattering layer that is provided between the barrier layers and the wavelength conversion layer, in which one of the barrier layers closest to the light scattering layer is formed of an inorganic component, the light scattering layer includes a binder, which is formed of either a compound having a hydrogen bonding functional group and a polymerizable group in a molecule or an organic metal coupling agent, and scattering particles having a diameter R of 0.2 to 5 ?m, a thickness d of the light scattering layer is 0.2 to 4 ?m, a thickness D of the wavelength conversion layer is 10 to 100 ?m, and a ratio of d to D is 0.2% to 10%.

Abstract: From experiments using colitis model mice, the present inventors discovered that siRNAs that suppress the CHST15 gene expression have a therapeutic effect against Crohn's disease or ulcerative colitis. Specifically, the present inventors discovered that the siRNAs which suppress the CHST15 gene expression can serve as an agent for promoting mucosal healing, in particular, an agent for treating Crohn's disease or ulcerative colitis, and thereby completed the present invention.

Abstract: A protection membrane-forming film (1) containing a filler, wherein the average particle size of the filler is not more than 0.4 ?m, a protection membrane-forming sheet (2), a production method and an inspection method for a workpiece or a processed product which use the film and the sheet, and a workpiece and a processed product determined as adequate products by the inspection method. The protection membrane-forming film and the protection membrane-forming sheet of the invention enable the formation of a protection membrane having excellent print legibility when subjected to print processing by laser irradiation.

Abstract: Provided is manufacturing method of a quantum dot-containing laminated body including: forming a coating film by applying a quantum dot-containing composition which contains quantum dots, a curable compound, and a thixotropic agent and has a viscosity in a case of a shear rate of 500 s?1 of 3 to 100 mPa·s and a viscosity in a case of a shear rate of 1 s?1 of equal to or greater than 300 mPa·s, onto a first base material; laminating a second base material onto the coating film; and applying external stimuli to the coating film sandwiched between the first base material and the second base material for hardening, and forming a quantum dot-containing layer. The manufacturing method realizes high productivity, obtains a quantum dot-containing layer without coating streaks, and has slight film thickness unevenness of the quantum dot-containing laminated body.

Abstract: Fatty liver was induced by administering agents for inducing organ inflammation to experimental animals to evoke insulin resistance and by rearing them with high-fat diets. As a result, steatohepatitis was successfully induced in the animals. The animals show pathological findings similar to those of humans. By using these model animals, substances for treating or preventing diseases can be efficiently screened and the efficacy of medicinal substances can be effectively evaluated.

Abstract: As a result of dedicated studies, the present inventors succeeded in discovering, for the first time, that fibrogenesis could be suppressed at the physiological tissue level by inhibiting sulfation at position 4 or 6 of GalNAc, which is a sugar that constitutes sugar chains. Furthermore, the present inventors conducted studies using various disease model animals, and as a result, successfully demonstrated that inhibitors of sulfation at position 4 or 6 of GalNAc had therapeutic effects on diseases caused by tissue fibrogenesis (tissue fibrogenic disorders).

Abstract: A protective film forming film 1 is provided in which the product of the breaking stress (MPa) measured at a measurement temperature of 0° C. and the breaking strain (unit: %) measured at a measurement temperature of 0° C. in at least one of the protective film forming film 1 and a protective film formed from the protective film forming film 1 is in a range of 1 MPa·% to 250 MPa·%. According to such a protective film forming film 1, the protective film forming film 1 or the protective film formed from the protective film forming film 1 can be suitably divided in an expanding process performed on a workpiece when the workpiece is divided to obtain a work product.

Abstract: Provided is protective film-forming sheet (2) including: a protective film-forming film (1) having a light transmittance at a wavelength of 1064 nm of 55% or greater and a light transmittance at a wavelength of 550 nm of 20% or less; and a release sheet (21) which is laminated on one or both faces of the protective film-forming film (1). According to this protective film-forming sheet (2), it is possible to form a protective film which allows a workpiece such as a semiconductor wafer to have a modified layer disposed in advance therein by a laser so that the workpiece can be split through the application of force thereon, while preventing grinding marks on the workpiece or a product formed therefrom from being visible to the naked eye.

Abstract: Provided is a sheet (2) for forming protective film, including: a protective film-forming film (1) characterized in that the light transmittance thereof at a wavelength of 1600 nm of 72% or more, and the light transmittance thereof at a wavelength of 550 nm of 20% or less; and a release sheet (21) laminated upon one or both faces of the protective film-forming film (1). According to this sheet (2) for forming a protective film, it is possible to form a protective film that allows for the inspection of cracks, etc., on a workpiece or a product obtained by processing the workpiece, while preventing grinding marks on the workpiece or the product from being visible to the naked eye.

Abstract: The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.

Abstract: From experiments using colitis model mice, the present inventors discovered that siRNAs that suppress the CHST15 gene expression have a therapeutic effect against Crohn's disease or ulcerative colitis. Specifically, the present inventors discovered that the siRNAs which suppress the CHST15 gene expression can serve as an agent for promoting mucosal healing, in particular, an agent for treating Crohn's disease or ulcerative colitis, and thereby completed the present invention.