Patents by Inventor Hisae Arai

Hisae Arai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-producing transgenic silkworms and methods for producing the same
    Patent number: 8952215
    Abstract: The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose expression is regulated directly or indirectly by the promoter, and which secrete the recombinant antibody into the silk gland. The recombinant antibodies produced from the silk gland of the transgenic silkworms were confirmed to be active.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: February 10, 2015
    Assignees: Nitto Boseki Co., Ltd., National Institute of Agrobiological Sciences
    Inventors: Toshiki Tamura, Isao Kobayashi, Toshio Kanda, Keiro Uchino, Katsuhiro Katayama, Tatsuya Ohashi, Iwao Kiyokawa, Hisae Arai, Noriyuki Funahashi
  • PLATINUM(IV) COMPLEXES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
    Publication number: 20140221475
    Abstract: New platinum(IV) complexes which has a strong antitumor activity and has a feature that a side effect is relatively reduced is provided. The new complex is platinum(IV) complexes with cis,cis-spiro[4,4]nonane-1,6-diamine ligand and is platinum(IV) complexes with optically active cis,cis-spiro[4,4]nonane-1,6-diamine ligand. Especially, the new complex is dichloromalonato((1S,5S,6S)-spiro[4.4]nonane-1,6-diamine)platinum(IV).
    Type: Application
    Filed: July 9, 2012
    Publication date: August 7, 2014
    Applicant: UNITECH CO., LTD.
    Inventors: Hisae Arai, Hisao Kondo, Norio Masuda
  • Platinum complex and pharmaceutical composition containing the same
    Patent number: 8501977
    Abstract: A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonane-1,6-diamineplatinum(II) complex which is represented by a following general formula (A). (In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z).) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: August 6, 2013
    Assignee: Unitech Co., Ltd.
    Inventors: Hisae Arai, Masaji Ohno, Hisao Kondo, Ikuko Arai
  • PLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
    Publication number: 20110152555
    Abstract: A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonane-1,6-diamineplatinum(II) complex which is represented by a following general formula (A). (In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z).) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.
    Type: Application
    Filed: August 25, 2009
    Publication date: June 23, 2011
    Applicant: UNITECH CO., LTD.
    Inventors: Hisae Arai, Masaji Ohno, Hisao Kondo, Ikuko Arai
  • TRANSGENIC SILKWORM CAPABLE OF PRODUCING ANTIBODY AND METHOD FOR PRODUCTION THEREOF
    Publication number: 20110021757
    Abstract: The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose expression is regulated directly or indirectly by the promoter, and which secrete the recombinant antibody into the silk gland. The recombinant antibodies produced from the silk gland of the transgenic silkworms were confirmed to be active.
    Type: Application
    Filed: October 18, 2006
    Publication date: January 27, 2011
    Applicants: NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES, NITTO BOSEKI CO., LTD., UNITECH CO., LTD
    Inventors: Toshiki Tamura, Isao Kobayashi, Toshio Kanda, Keiro Uchino, Katsuhiro Katayama, Tatsuya Ohashi, Iwao Kiyokawa, Hisae Arai, Noriyuki Funahashi