Abstract: An object of the present invention is to provide a means for detecting or quantitatively determining short-chain nucleic acids by simple double-strand formation with high specificity. The present invention relates to a polynucleobase probe including, in a sequence complementary to a target sequence having at least one sequence of any one of SEQ ID NOs: 1 to 10, a sequence in which at least one of bases in a portion complementary to any one sequence of SEQ ID NOs: 1 to 10 in the target sequence becomes abasic and/or is substituted; a method for designing the same; and a method for utilizing the same.

Abstract: A method for treating a solution including nucleic acid, comprising the steps of: arranging the solution on a first surface of a first base material having the first surface, which has a well defined by an electrode and a resist; and after arranging the solution on the first surface of the first base material, pressing the first base material and a second base material, which has a hydrophobic second surface, together so that the second surface of the second base material and the first surface of the first base material face each other.

Abstract: An object of the present invention is to provide a means for detecting or quantitatively determining short-chain nucleic acids by simple double-strand formation with high specificity. The present invention relates to a polynucleobase probe including, in a sequence complementary to a target sequence having at least one sequence of any one of SEQ ID NOs: 1 to 10, a sequence in which at least one of bases in a portion complementary to any one sequence of SEQ ID NOs: 1 to 10 in the target sequence becomes abasic and/or is substituted; a method for designing the same; and a method for utilizing the same.

Abstract: The main object of the invention is to provide a compound that can be used as a sensitizing dye of a dye-sensitized solar cell, which can realize outstanding endurance and photovoltaic conversion efficiency. 1. A compound shown by the following general formula (1) is therefore provided: (wherein, in the formula (1), Y is a hydroxyl group or an amino group; E1 is N or CH; L is a hydrogen atom or a photosensitizing group; R is a group having one of the basic units D shown by the following general formula (D), or a group having a branched structure wherein a structural unit is repeatedly bonded via a peptide linkage, this structural unit being 1-100 of the basic units D and 1-100 of the basic units G shown by the following general formula (G). The photosensitizing group is bonded to 50% or more of the nitrogen atoms among the nitrogen atoms which do not constitute the peptide linkage of this group, hydrogen atoms being bonded to the remaining nitrogen atoms).

Abstract: An object of the present invention is to provide a compound with a structure wherein amino acid or oligopeptide side chains are bonded to a main chain. The present invention provides a compound represented by the following formula (1). wherein n1 to n3, and m1 to m6 are certain integers; Y is a hydroxyl or an amino group; E is N or CH; R is an amino acid residue, or a peptide residue consisting of 2 to 100 amino acid residues; and L is a hydrogen atom, a group containing a lipid group, a group containing a fatty acid residue, or a group containing a fluorescent group.

Abstract: A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.

Abstract: A compound represented by general formula (I) below; (in the formula, A denotes B denotes R denotes H, NO2, NH2, NHCbz, Br, F, Cl or SO3Na2, and n is an integer of 1 to 4), and a process for producing the above compound characterised in that it includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ?-amino acid derivative.

Abstract: A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.

Abstract: A compound represented by the general formula (I) below: In the formula, A is as defined in the specification and B denotes where n is an integer of 1 to 4, and a process for producing the above compound includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ?-amino acid derivative.

Abstract: A functional molecule can be introduced extremely rapidly and with superior cost performance by using a method for producing a functional PNA oligomer that comprises synthesizing a PNA oligomer by reacting a PNA monomer unit having a protected adenine, guanine, cytosine or thymine with Boc-lysine(Fmoc)-OH or Fmoc-lysine(Alloc)-OH, followed by introducing a functional molecule having a free carboxylic acid into said PNA oligomer and de-protecting the protecting group. Moreover, Boc-lysine (Fmoc)-OH or Fmoc-lysine(Alloc)-OH can be produced that functions as a compound and precursor PNA monomer unit synthesized according to this method.

Abstract: The object of the present invention is to provide functional PNA monomer units and a novel synthesis method for functional PNA oligomers for introducing a plurality of functional molecules at arbitrary locations by means of linkers having various lengths either directly or post-synthetically even in the case of compounds that are unstable in liquid under acidic, alkaline or neutral conditions, along with novel functional PNA monomer units and functional PNA oligomers. This object is achieved by means of a compound in the form of a functional PNA monomer unit, and production method thereof, represented by the following general formula (I): (wherein R represents H, a functional molecule or a protecting group, and n represents an integer of 1 to 11).

Abstract: A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.

Abstract: A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.

Abstract: A novel method for synthesizing functional PNA having superior cost performance and which enables functional molecules to be introduced extremely rapidly, and compounds used therein. Disclosed is a method for producing a functional PNA oligomer; wherein a PNA monomer unit having adenine, guanine, cytosine or thymine protected by a protecting group is reacted with Fmoc-&ohgr;-amino acid-BocPNA-OH, and after synthesizing PNA oligomer, a functional molecule having free carboxylic acid is introduced into that PNA oligomer followed by deprotecting the protecting group; compounds synthesized by the method; and, Fmoc-&ohgr;-amino acid-BocPNA-OH that functions as a precursor PNA monomer unit.

Abstract: A compound represented by general formula (I) below; 1

Abstract: A process for amino acid derivatives shown by the below general formula (I): 1

Abstract: A novel method for synthesizing functional PNA having superior cost performance and which enables functional molecules to be-introduced extremely rapidly, and compounds used therein. Disclosed is a method for producing a functional PNA oligomer; wherein a PNA monomer unit having adenine, guanine, cytosine or thymine protected by a protecting group is reacted with. Fmoc-&ohgr;-amino acid-BocPNA-OH, and after synthesizing PNA oligomer, a functional molecule having free carboxylic acid is introduced into that PNA oligomer followed by deprotecting the protecting group; compounds synthesized by the method; and, Fmoc-&ohgr;-amino acid-BocPNA-OH that functions as a precursor PNA monomer unit.