Abstract: There is provided a imaging device including: an N-type region formed for each pixel and configured to perform photoelectric conversion; an inter-pixel light-shielding wall penetrating a semiconductor substrate in a depth direction and formed between N-type regions configured to perform the photoelectric conversion, the N-type regions each being formed for each of pixels adjacent to each other; a P-type layer formed between the N-type region configured to perform the photoelectric conversion and the inter-pixel light-shielding wall; and a P-type region adjacent to the P-type layer and formed between the N-type region and an interface on a side of a light incident surface of the semiconductor substrate.

Abstract: An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine during production is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a saccharide, influenza vaccine, a natural amino acid or a salt thereof, and a surfactant and the influenza vaccine is administered into a body by dissolution of the needle portions.

Abstract: An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a water-soluble polymer, influenza vaccine, and meglumine or a salt thereof, and the influenza vaccine is administered into a body by dissolution of the needle portions.

Abstract: It is an object of the present invention to provide a Japanese encephalitis vaccine-containing microneedle array capable of suppressing a reduction in the activity of the Japanese encephalitis vaccine upon the production of the microneedle array. According to the present invention, provided is a microneedle array having a sheet portion and a plurality of needle portions present on the upper surface of the sheet portion, wherein the needle portion comprises at least one of an electrically neutral water-soluble polymer and a disaccharide, a Japanese encephalitis vaccine, and an electrically neutral surfactant, and the sheet portion comprises at least one of an electrically neutral water-soluble polymer and a disaccharide.

Abstract: A water-based cosmetic that includes: (A) ceramidic compound-containing particles that include a ceramidic compound and that are dispersed as an oil phase in an aqueous phase; (B) a fatty acid component composed of at least one selected from the group consisting of fatty acids and fatty acid salts; and (C) a polyhydric alcohol component that includes a first polyhydric alcohol having an IOB of 2.2 or more and a total content in the composition of from 3% by mass to 20% by mass, and a second polyhydric alcohol having an IOB of 2.0 or less and a total content in the composition of 0% by mass or not more than 3% by mass, wherein a total content of surfactant in the composition is 0% by mass or not more than 1% by mass, and a total mass of ceramidic compound in the composition is at least 3.0 times a total mass of the fatty acid component in the composition.

Abstract: A water-based cosmetic that includes: (A) ceramidic compound-containing particles that include a ceramidic compound and that are dispersed as an oil phase in an aqueous phase; (B) a fatty acid component composed of at least one selected from the group consisting of fatty acids and fatty acid salts; and (C) a polyhydric alcohol component that includes a first polyhydric alcohol having an IOB of 2.2 or more and a total content in the composition of from 3% by mass to 20% by mass, and a second polyhydric alcohol having an IOB of 2.0 or less and a total content in the composition of 0% by mass or not more than 3% by mass, wherein a total content of surfactant in the composition is 0% by mass or not more than 1% by mass, and a total mass of ceramidic compound in the composition is at least 3.0 times a total mass of the fatty acid component in the composition.

Abstract: An orally disintegrating tablet including: fine granules, each fine granule having, at its center, an active pharmaceutical ingredient-containing core that includes butylscopolamine bromide and water-insoluble particles, and having an intermediate layer that includes water-insoluble particles and coats the active pharmaceutical ingredient-containing core, and a bitterness-masking layer that includes talc and at least one water-insoluble polymer, in sequence from the active pharmaceutical ingredient-containing core side; and an excipient component positioned on the outside of the fine granules, and a method for producing the same.

Abstract: The present invention provides a ceramide dispersion which includes (1) ceramide-containing particles which contains a ceramide, which are dispersed in an aqueous phase as an oil-phase component, and which have a volume average particle diameter from 1 nm to 100 nm; and (2) a fatty acid component which is at least one of a fatty acid having a melting temperature not higher than 30° C. or a fatty acid salt; the amount of nonionic surfactant being 0 or not more than 0.1 times the total mass of the ceramide; the amount of an ionic surfactant other than the fatty acid component being 0 or less than 0.05 times the total mass of the ceramide; and the pH being from 6 to 8.

Abstract: A water-based cosmetic that includes: (A) ceramidic compound-containing particles that include a ceramidic compound and that are dispersed as an oil phase in an aqueous phase; (B) a fatty acid component composed of at least one selected from the group consisting of fatty acids and fatty acid salts; and (C) a polyhydric alcohol component that includes a first polyhydric alcohol having an IOB of 2.2 or more and a total content in the composition of from 3% by mass to 20% by mass, and a second polyhydric alcohol having an IOB of 2.0 or less and a total content in the composition of 0% by mass or not more than 3% by mass, wherein a total content of surfactant in the composition is 0% by mass or not more than 1% by mass, and a total mass of ceramidic compound in the composition is at least 3.0 times a total mass of the fatty acid component in the composition.

Abstract: The present invention provides: a dispersion composition including a poorly water-soluble polyphenol compound, an emulsifier including a sucrose fatty acid ester, and a water-soluble polymer, in which a content of a polyglycerin fatty acid ester in the composition is 0, or 0.

Abstract: The present invention provides a ceramide dispersion which includes (1) ceramide-containing particles which contain a ceramide, which are dispersed in an aqueous phase as an oil-phase component and which have a volume average particle diameter from 1 nm to 100 nm, (2) a fatty acid component which is at least one of a fatty acid and a fatty acid salt, (3) a polyhydric alcohol in an amount from 5 to 20 times larger than an amount of the ceramide and (4) a polysaccharide fatty acid ester; and in which the pH is from 6 to 8.

Abstract: The present invention provides a ceramide dispersion which includes (1) ceramide-containing particles which contains a ceramide, which are dispersed in an aqueous phase as an oil-phase component, and which have a volume average particle diameter from 1 nm to 100 nm; and (2) a fatty acid component which is at least one of a fatty acid having a melting temperature not higher than 30° C. or a fatty acid salt; the amount of nonionic surfactant being 0 or not more than 0.1 times the total mass of the ceramide; the amount of an ionic surfactant other than the fatty acid component being 0 or less than 0.05 times the total mass of the ceramide; and the pH being from 6 to 8.

Abstract: The present invention provides an a aqueous cosmetic preparation which includes at least a ceramide analog-containing particle that contains at least a ceramide analog and has a volume average particle diameter of from 2 nm to 150 nm, the particle is dispersed in an aqueous phase as an oil-phase component, and a fatty acid having 10 to 30 carbon atoms or salt thereof. The aqueous cosmetic preparation satisfies at least either a condition where the pH is 5.5 or more or a condition where the electric conductivity is 5.0 mS/cm or less.

Abstract: A ceramide dispersion, which includes at least: natural-ceramide-containing particles that are dispersed in an aqueous phase as an oil-phase component; and at least one surfactant, wherein the natural-ceramide-containing particles contain one or more natural ceramides in an amount of 50% by mass or higher with respect to the total mass of the oil components contained in an oil phase, and have a volume average particle diameter of from 0.5 nm to 100 nm; and the ceramide dispersion contains, in the at least one surfactant, at least one polyglycerin fatty acid ester having an HLB of from 10 to 16.

Abstract: A topical composition for external use comprising: a ceramide analogue-containing particle having a particle diameter of 0.001 ?m to 0.2 ?m; and a water-soluble polymer. It is preferable that, further, an oil component different from the ceramide analogue is contained in an amount of 20 parts by mass or less relative to 1 part by mass of the ceramide analogue-containing particle, and the ceramide analogue-containing particle is present in the oil component.

Abstract: According to the present invention, there is provided a curable composition, containing a compound (A) having at least one ethylenically unsaturated double bond, a photopolymerization initiator (B), a coloring agent (C), an alkali-soluble resin (D), and a compound (E) having in the molecule a partial structure of urethane, amide or urea.

Abstract: The present invention provides that a method for preparing an emulsion or a dispersion composed of an oily phase and an aqueous phase by contacting the oily phase with the aqueous phase, the method comprising: injecting the oily phase, which contains a water-soluble organic solvent and at least one hydrophobic functional ingredient and in which the content of a surfactant is approximately 0.1% by mass or less based on the total mass of the oily phase, into the aqueous phase such that the Reynolds number of the oily phase immediately before contact with the aqueous phase is approximately 1,000 or more, and that foodstuffs, a skin external and a medicament which contain an emulsion or a dispersion prepared by the method described above.

Abstract: According to the present invention, there is provided a curable composition, containing a compound (A) having at least one ethylenically unsaturated double bond, a photopolymerization initiator (B), a coloring agent (C), an alkali-soluble resin (D), and a compound (E) having in the molecule a partial structure of urethane, amide or urea.

Abstract: A heat sensitive recording material comprising a support and a heat sensitive recording layer containing a diazonium salt compound disposed on the support, wherein a compound represented by following formula (1) is contained in the heat sensitive recording material, as well as a microcapsule containing a diazonium salt compound and the compound represented by the following formula (1): in which R1 to R5 each independently represent a hydrogen atom, halogen atom or a substituted or non-substituted alkyl group, alkenyl group, aryl group, alkoxy group, or aryloxy group; R6 to R8 each independently represent a hydrogen atom or a substituted or non-substituted alkyl group or aryl group; and R1 and R7, R1 to R5, and R6 and R8 may join with each other to form a ring, providing that a ring formed by joining of R1 and R7, or R6 and R8 does not form an aromatic ring.

Abstract: The present invention provides a thermosensitive recording material comprising a support and a thermosensitive recording layer containing, as color forming components, an electron donating dye precursor encapsulated in microcapsules and an electron accepting compound, the electron accepting compound containing a salicylic acid metal salt represented by the following General Formula (1): 1