Abstract: A diclofenac-containing patch package product, in which a diclofenac-containing patch, including an adhesive layer containing diclofenac sodium as a drug and dimethyl sulfoxide as a solvent, and a backing layer, is sealed in a packaging bag, the packaging bag being formed of a laminate at least comprising: an innermost layer composed of at least one selected from the group consisting of polyethylene terephthalate and cycloolefin polymer; an oxygen barrier layer arranged outside the innermost layer; and an outer layer arranged outside the oxygen barrier layer.

Abstract: The present invention provides a transdermal patch comprising an adhesive layer on a backing, wherein the adhesive layer comprises a drug, DMSO, and an adhesive base, and the adhesive base comprises a styrene-based thermoplastic elastomer having a triblock content of 35% to 65%.

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

Abstract: The purpose of the invention is to produce an imidafenacin-containing percutaneously absorbed preparation, wherein the drug not only is not allowed to crystallize but also has adequate skin penetration. The imidafenacin-containing percutaneously absorbed preparation comprises isostearic acid and a fatty acid ester, which function as crystallization-preventing agents.

Abstract: The purpose of the invention is to produce an imidafenacin-containing percutaneously absorbed preparation, wherein the drug not only is not allowed to crystallize but also has adequate skin penetration. The imidafenacin-containing percutaneously absorbed preparation comprises isostearic acid and a fatty acid ester, which function as crystallization-preventing agents.

Abstract: Provided is a percutaneous absorption type formulation of a drug such as imidafenacin and silodosin, wherein stable absorption through the skin is realized. The percutaneous absorption type formulation containing a drug such as imidafenacin and silodosin further contains a transdermal absorption promoting agent, and fatty acid ester and/or fatty acid amide that further improve(s) the function of the transdermal absorption promoting agent.

Abstract: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.

Abstract: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.

Abstract: Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm3)1/2 and a have a very excellent skin permeability of the drug.

Abstract: Adhesive preparations with improved percutaneous absorption of physiologically active substances, in particular, matrix adhesive preparations containing a base drug salt and an organic acid salt having an mean diameter of from 0.1 to 100 ?m are provided.

Abstract: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.

Abstract: An optical repeater includes an optical splitter for splitting an optical input data pulse stream of wavelength &lgr;0 into first and second components. The first component is supplied to a first. mode-locked laser diode to produce a first clock pulse stream of wavelength &lgr;1 which is synchronized to the input data pulse stream. The first clock pulse stream is fed to a second mode-locked laser diode to produce a second clock pulse stream of wavelength &lgr;0 which is synchronized to the first clock pulse stream. The second clock pulse stream is entered to an optical gate. The second component of the input data from the splitter is amplified sufficiently to control the optical gate to modulate the second clock pulse stream so that the data pulse pattern is impressed on the second clock pulse stream.

Abstract: A method for measuring the waveform of light is provided, which makes it possible to synchronize easily the phase of sampling light with the phase of target light even if the target light is ultra-high speed pulsed light and is transmitted by way of long transmission channel, and to measure the waveform of target light with sufficient time resolution in real time. The method comprises the steps of: (a) generating sampling light having a pulse width sufficiently narrower than that of the target light from the target light; a repetition frequency of the sampling light having a constant difference with respect to a repetition frequency of the target light; (b) supplying the sampling light and the target light to a nonlinear optical member to generate cross-correlated light between the sampling light and the target light; and (c) measuring waveform of the target light based on the cross-correlated light.

Abstract: A method for measuring the waveform of light is provided, which makes it possible to synchronize easily the phase of sampling light with the phase of target light even if the target light is ultra-high speed pulsed light and is transmitted by way of long transmission channel, and to measure the waveform of target light with sufficient time resolution in real time. The method comprises the steps of: (a) generating sampling light having a pulse width sufficiently narrower than that of the target light from the target light; a repetition frequency of the sampling light having a constant difference with respect to a repetition frequency of the target light; (b) supplying the sampling light and the target light to a nonlinear optical member to generate cross-correlated light between the sampling light and the target light; and (c) measuring waveform of the target light based on the cross-correlated light.

Abstract: An optical connector comprises a series of transparent substrates 50-53 including a refraction type lens 10 embedded in the central substrate 50, two beam deflection elements 40 and 41 offset from the optical axis of the lens 10, a light emitting element 20 directly below the beam deflection element 40, and a light detecting element 30 directly above the beam deflection element 41. The lens 10 is designed to have identical meridional and sagittal focal lengths so that meridional and sagittal images of obliique incident beams may be formed on the same spot on the light detecting element 30. Beam of light emitted from the light emitting element 20 are deflected by the beam deflection element 40 and enters the lens 10 obliquely. The beams, passing through the lens 10 and the deflection element 41 are cllimated within a small spot on the light detecting element 30 since the lens 10 has identical meridional and sagittal focal lengths.