Patents by Inventor Hisaki Kajino
Hisaki Kajino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160137644Abstract: It is an object of the present invention to provide a method for producing a high-purity tricyclic heterocyclic compound represented by formula (I), which is useful as a production intermediate for a pharmaceutical agent, wherein the method is an efficient production method with short steps and with a high yield, which does not use, as raw materials, expensive bromopyruvate and highly harmful copper chromite, and does not need silica gel column chromatography that generates, as by-products, large quantities of waste. The present invention relates to production of Compound (I) by the following method.Type: ApplicationFiled: June 25, 2014Publication date: May 19, 2016Applicant: Daiichi Sankyo Company, LimitedInventors: Hisaki Kajino, Makoto Michida, Yasuo Takahashi, Yasuhisa Kuwahara
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Patent number: 8815880Abstract: To provide a hydrochloride of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90 and a crystal thereof. The present invention provides a hydrochloride of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a crystal thereof, a medicament comprising the same, an anticancer agent comprising the same, and the like.Type: GrantFiled: February 21, 2013Date of Patent: August 26, 2014Assignee: Daiichi Sankyo Company, LimitedInventors: Shinji Matuura, Hisaki Kajino, Tomoyuki Nagai, Keijiro Kobayashi
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Publication number: 20120252854Abstract: A crystalline form of a hydrate of a dihydrochloride 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione represented by the following formula: wherein the crystalline form shows main peaks at interplanar spacings of 10.42, 5.85, 5.52, 3.84, 3.46 and 2.95 angstroms in X-ray powder diffraction obtained with Cu K? line radiation (wavelength ?=1.54 angstroms).Type: ApplicationFiled: May 7, 2012Publication date: October 4, 2012Applicant: DAIICHI-SANKYO COMPANY, LIMITEDInventors: Hisaki Kajino, Yutaka Ikeuchi, Hiroshi Miyamoto, Eiji Numagami, Satoru Nihei
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Publication number: 20120238759Abstract: A method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative represented by the formula (IV) wherein R3 represents a hydrogen atom or a C1-C4 alkyl group. A 4-substituted N2-methylbenzene-1,2-diamine derivative is prepared from a particular 5-substituted N-methyl-2-nitroaniline derivative, subsequently reacting the resulting compound with {4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy}acetic acid or an acid chloride or a mixed acid anhydride thereof, and subsequently subjecting the resulting compound to intramolecular dehydration condensation. A compound of the formula (II) wherein R1 represents a hydrogen atom, a C1-C4 alkyl group, or a protective group for the nitrogen atom, and R2 represents a hydrogen atom or a protective group for the nitrogen atom is prepared and used as an intermediate.Type: ApplicationFiled: November 25, 2010Publication date: September 20, 2012Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Yutaka Ikeuchi, Chiharu Satoh, Eiji Numagami, Satoru Nihei, Hisaki Kajino
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Patent number: 8236834Abstract: It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I).Type: GrantFiled: February 8, 2008Date of Patent: August 7, 2012Assignee: Daiichi Sankyo Company, LimitedInventors: Hisaki Kajino, Yutaka Ikeuchi, Eiji Numagami
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Patent number: 8106079Abstract: A compound having the following formula (III) wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.Type: GrantFiled: May 19, 2010Date of Patent: January 31, 2012Assignee: Sankyo Company, LimitedInventors: Hisaki Kajino, Hiroshi Miyamoto, Yutaka Ikeuchi
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Publication number: 20110213158Abstract: It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I).Type: ApplicationFiled: February 8, 2008Publication date: September 1, 2011Inventors: Hisaki Kajino, Yutaka Ikeuchi, Hiroshi Miyamoto, Eiji Numagami, Satoru Nihei
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Publication number: 20110160462Abstract: Thiazolidinedione compound crystalline forms useful as a bulk material for the manufacture of a peroxisome proliferator-activated receptor (PPAR) ? activator or an anticancer pharmaceutical composition are provided, which are hydrate crystalline forms of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimi dazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione represented by Formula (I) below and of its dihydrochloride.Type: ApplicationFiled: July 30, 2009Publication date: June 30, 2011Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Hisaki Kajino, Eiji Numagami, Satoru Nihei
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Publication number: 20110124692Abstract: Thiazolidinedione compound crystalline forms useful as a bulk material for the manufacture of a peroxisome proliferator-activated receptor (PPAR) ? activator or an anticancer pharmaceutical composition are provided, which are hydrate crystalline forms of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimi dazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione represented by Formula (I) below and of its dihydrochloride.Type: ApplicationFiled: July 30, 2009Publication date: May 26, 2011Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Hisaki Kajino, Yutaka Ikeuchi, Eiji Numagami, Satoru Nihei
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Publication number: 20110092555Abstract: A compound which is 5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}thiazolidine-2,4-dione hydrochloride, in crystal form wherein a powder x-ray diffraction pattern obtained by irradiation with a Cu K? line shows main peaks at interplanar spacings d=14.29, 7.12, 5.34, 4.97, 4.74, 3.95, 3.85, 3.75, 3.55, 3.51, 3.15, 2.84, 2.76, 2.52 and 2.37.Type: ApplicationFiled: December 14, 2010Publication date: April 21, 2011Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Yoshitaka Nakamura, Chiharu Satoh, Hiroshi Miyamoto, Hisaki Kajino
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Publication number: 20110046388Abstract: It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I).Type: ApplicationFiled: February 8, 2008Publication date: February 24, 2011Inventors: Hisaki Kajino, Yutaka Ikeuchi, Hiroshi Miyamoto, Eiji Numagami, Satoru Nihei
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Patent number: 7816552Abstract: A method for preparing a compound having the following formula (I) by reducing a nitro group of the following formula (III) followed by carrying out an intramolecular dehydration condensation, wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen.Type: GrantFiled: September 26, 2005Date of Patent: October 19, 2010Assignee: Sankyo Company, LimitedInventors: Hisaki Kajino, Hiroshi Miyamoto, Rei Okazaki, Yutaka Ikeuchi
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Publication number: 20100234612Abstract: A compound having the following formula (III) wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.Type: ApplicationFiled: May 19, 2010Publication date: September 16, 2010Applicant: SANKYO COMPANY, LIMITEDInventors: Hisaki Kajino, Hiroshi Miyamoto, Yutaka Ikeuchi
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Publication number: 20090023929Abstract: A method for preparing a compound having the following formula (I) by reducing a nitro group of the following formula (III) followed by carrying out an intramolecular dehydration condensation, wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen.Type: ApplicationFiled: September 26, 2005Publication date: January 22, 2009Inventors: Hisaki Kajino, Hiroshi Miyamoto, Rei Okazaki, Yutaka Ikeuchi
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Publication number: 20080103185Abstract: There are provided crystals of a thiazolidinedione derivative having excellent prophylactic and therapeutic effects on a disease caused by insulin resistance and a process for producing the thiazolidinedione derivative with a high purity.Type: ApplicationFiled: January 24, 2006Publication date: May 1, 2008Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Yoshitaka Nakamura, Chiharu Satoh, Hiroshi Miyamoto, Hisaki Kajino
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Patent number: 5212322Abstract: Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substituents;R.sup.Type: GrantFiled: January 22, 1991Date of Patent: May 18, 1993Assignee: Sankyo Company, LimitedInventors: Takao Okazaki, Shuji Takahashi, Seigo Iwado, Keiji Tanaka, Toshiaki Yanai, Hisaki Kajino
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Patent number: 5134152Abstract: Compounds of formula (I): ##STR1## [in which: R.sup.1 and R.sup.2 are hydrogen or alkyl, or together are cycloalkyl; R.sup.3 and R.sup.4 are hydrogen, alkyl or phenyl, or together are cycloalkyl; or R.sup.1 and R.sup.3 together are cycloalkyl fused to the oxetane ring; Ar is phenyl substituted by R.sup.5, R.sup.6 and R.sup.7, where R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl, alkoxy, halogenated alkyl or halogenated alkoxy; and R.sup.8 and R.sup.9 are hydrogen or alkyl] and salts thereof have valuable agricultural and pharmaceutical anti-fungal or fungicidal activity. They may be prepared by a variety of processes.Type: GrantFiled: December 4, 1990Date of Patent: July 28, 1992Assignee: Sankyo Company, LimitedInventors: Hideo Takeshiba, Junzo Tobitsuka, Kazuo Sato, Hisaki Kajino, Hiroyuki Itoh, Yukiyoshi Takahi, Hiroshi Ohta, Sadao Oida, Noriko Takeda, Toshiyuki Konosu, Hiroshi Yasuda
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Patent number: 5008191Abstract: Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substitutents;R.sup.Type: GrantFiled: December 10, 1987Date of Patent: April 16, 1991Assignee: Sankyo Company LimitedInventors: Takao Okazaki, Shuji Takahashi, Seigo Iwado, Keiji Tanaka, Toshiaki Yanai, Hisaki Kajino