Abstract: An out-of-head localization filter determination system according to an embodiment includes headphones, a microphone unit, a measurement processor, and a server device. The measurement processor measures first ear canal transfer characteristics from a first position to a microphone, measures ear canal transfer characteristics from a second position to a microphone, and transmits user data related to the first ear canal transfer characteristics to the server device. The server device includes a storage unit that stores first preset data and a second preset data in association with each other, a comparison unit that compares the second preset data with the user data, and an extraction unit that extracts the first preset data according to a comparison result.

Abstract: New camptothecin derivatives, useful as antitumor agents or intermediates therefor, of the general formula (I) ##STR1## wherein X is a lower alkyl group, and R is a hydrogen atom or the grouping -COY where Y is a linear or branched unsubstituted C.sub.1 -C.sub.18 alkyl group; a lower alkyl group substituted by a halogen atom or a lower alkylthio, amino, acylamino, hydroxyl, lower alkoxy, aryloxy or lower alkoxycarbonyl group; a C.sub.3 -C.sub.19 alkenyl, C.sub.3 -C.sub.19 alkynyl or C.sub.3 -C.sub.8 cycloalkyl group; a C.sub.3 -C.sub.