Patents by Inventor Hisanao Hiramatsu

Hisanao Hiramatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamer for NGF and use thereof
    Patent number: 10260070
    Abstract: Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: April 16, 2019
    Assignees: RIBOMIC INC., FUJIMOTO PHARMACEUTICAL CORPORATION
    Inventors: Ling Jin, Shin Miyakawa, Masatoshi Fujiwara, Yoshikazu Nakamura, Hisanao Hiramatsu
  • NGF aptamer and application thereof
    Patent number: 9567589
    Abstract: The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I): wherein N is one nucleotide selected from the group consisting of A, G, C, U and T, N11-N13, N21-N23, N32-N38 and N42-N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T, N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T, N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair, N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, and N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 14, 2017
    Assignees: RIBOMIC INC., FUJIMOTO PHARMACEUTICAL CORPORATION
    Inventors: Ling Jin, Hisanao Hiramatsu
  • Aptamer for NGF and use thereof
    Patent number: 9175292
    Abstract: Provided is a higher quality aptamer having a binding activity to NGF. An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: November 3, 2015
    Assignees: FUJIMOTO PHARMACEUTICAL CORPORATION, RIBOMIC INC.
    Inventors: Yoshikazu Nakamura, Ling Jin, Hisanao Hiramatsu
  • NGF APTAMER AND APPLICATION THEREOF
    Publication number: 20140235701
    Abstract: The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I): wherein N is one nucleotide selected from the group consisting of A, G, C, U and T, N11-N13, N21-N23, N32-N38 and N42-N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T, N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T, N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair, N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, and N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Inventors: Ling Jin, Hisanao Hiramatsu
  • APTAMER FOR NGF AND USE THEREOF
    Publication number: 20130052176
    Abstract: Provided is a higher quality aptamer having a binding activity to NGF. An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
    Type: Application
    Filed: March 24, 2011
    Publication date: February 28, 2013
    Applicants: SHIONOGI & CO., LTD, RIBOMIC INC.
    Inventors: Yoshikazu Nakamura, Ling Jin, Hisanao Hiramatsu
  • APTAMER FOR NGF AND USE THEREOF
    Publication number: 20110251266
    Abstract: Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.
    Type: Application
    Filed: September 18, 2009
    Publication date: October 13, 2011
    Applicants: Shionogi & Co., Ltd., RIBOMIC INC.
    Inventors: Ling Jin, Shin Miyakawa, Masatoshi Fujiwara, Yoshikazu Nakamura, Hisanao Hiramatsu