Patents by Inventor Hisao Kakegawa
Hisao Kakegawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070295669Abstract: This invention provides a method of removing toxic substances such as fluorine, boron, copper, lead, arsenic, hexavalent chromium, and cadmium from strongly acid wastewater safely and without fail. The method comprises the steps of (i) adding hydroxyapatite 11 to strongly acid wastewater 1A to precipitate its toxic substances as solid constituents, (ii) adding an alkaline substance 12 to the wastewater 1A to neutralize it, (iii) adding a coagulant 13 to the wastewater 1A to coagulate the precipitated solid constituents, and (iv) removing the coagulated solid constituents from the wastewater 1A. According to this method, toxic substances in the strongly acid wastewater 1A can be fixed, or immobilized, effectively and removed safely. Besides, because the strongly acid wastewater 1A can be treated at normal temperature without heating it in any step, the wastewater 1A can be treated safely.Type: ApplicationFiled: March 31, 2004Publication date: December 27, 2007Applicant: National University Corporation Kagawa UniversityInventors: Hisao Kakegawa, Yoshihiro Suenaga, Shuzo Kakinuma
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Patent number: 5264421Abstract: A food composition prepared from a lactic acid fermented aqueous liquorice extract which is free of the disadvantages of extremely strong sweetness which makes liquorice extracts unsuitable for maintaining and enhancing the pharmacological activities (both disease preventing and treating effects) of treating ulcers and hepatic diseases.Type: GrantFiled: April 6, 1992Date of Patent: November 23, 1993Assignee: Nippon Hypox Laboratories, IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Yasunori Niiro, Hisao Kakegawa, Tokutaro Miki
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Patent number: 5194445Abstract: The preparation for preventing and curing organ dysfunctions, provided by the present invention, is a medicament having the activity to prevent and cure organ dysfunctions which active oxygen species and active organic radical species would cause, and unconventionally improved in stability in vivo by containing, as an active component, the ascorbic acid derivative of the formula, ##STR1## wherein R.sub.2 is a group selected from the class consisting of an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms, an alkyl group having 9 inclusive to 17 inclusive alkyl groups and an alkoxycarbonyl lower alkyl group of which the terminal alkoxy group has 7 inclusive to 20 inclusive carbon atoms; and the ascorbic acid derivative of the above formula in which R.sub.Type: GrantFiled: May 20, 1991Date of Patent: March 16, 1993Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5143648Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: August 20, 1991Date of Patent: September 1, 1992Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5109025Abstract: 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.Type: GrantFiled: July 25, 1990Date of Patent: April 28, 1992Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: 5061812Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: July 20, 1989Date of Patent: October 29, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5034543Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: July 20, 1989Date of Patent: July 23, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5011949Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned novel ascorbic acid derivative or other known ascorbic acid derivatives.Type: GrantFiled: July 20, 1989Date of Patent: April 30, 1991Assignee: Nippon Hypox Laboratories, Inc.Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 5006548Abstract: Compounds of the general formula: ##STR1## wherein R.sup.1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R.sup.2 is hydrogen, halogen, or nitro, and R.sup.3 is carboxy group or its functional derivative, with the proviso that when R.sup.1 is an unsubstituted furyl, or furyl mono- or polysubstituted with alkyl and R.sup.2 is hydrogen, then R.sup.3 is functional derivative of carboxy and, where applicable, pharmaceutically acceptable salts thereof are hyaluronidase inhibitors and useful as anti-allergic agent.Type: GrantFiled: August 7, 1989Date of Patent: April 9, 1991Assignee: Sawai Pharmaceutical Co., Ltd.Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
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Patent number: 5004742Abstract: The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.Type: GrantFiled: August 14, 1989Date of Patent: April 2, 1991Assignee: Nippon Hypox Laboratories IncorporatedInventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
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Patent number: 4898890Abstract: A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.Type: GrantFiled: December 23, 1987Date of Patent: February 6, 1990Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Sato, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: 4822791Abstract: This invention relates to pharmaceutical compositions of compounds of the general formula: ##STR1## wherein R.sup.1 is an aryl group or a substituted aryl group wherein the substituent is halogen, hydroxy, C.sub.(1-6) lower alkoxy, C.sub.(1-6) lower alkylenedioxy, halo C.sub.(1-6) lower alkyl, cyano, nitro, mono- or di-C.sub.(1-6) alkylamino or C.sub.(1-6) lower alkanoylamino; or a 5-membered or 6-membered C.sub.(1-6) alkyl substituted or unsubstituted heterocyclic group containing a heteroatom selected from oxygen, nitrogen, and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, and R.sup.2 and R.sup.2' are, independently, hydrogen, halogen, nitro, C.sub.(1-6) lower alkyl or C.sub.(1-6) lower alkoxy. These compounds have been found to exhibit hyaluronidase inhibiting activity, anti-allergic activity and anti-ulcerous activity.Type: GrantFiled: March 2, 1988Date of Patent: April 18, 1989Assignee: Sawai Pharmaceutical Co., Ltd.Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
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Patent number: 4755506Abstract: Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, andR.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen,and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.Type: GrantFiled: September 19, 1986Date of Patent: July 5, 1988Assignee: Sawai Pharmaceutical Co., Ltd.Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
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Patent number: 4732916Abstract: A guanidinomethylbenzoic acid derivative represented by the formula ##STR1## or a salt thereof. An antiulcer agent comprising the compounds of the afore-said formula as an effective ingredient is also disclosed.Type: GrantFiled: July 16, 1986Date of Patent: March 22, 1988Assignees: Kabushiki Kaisha Med-Creat, Toshio SatohInventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: 4634777Abstract: Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, andR.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen,and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.Type: GrantFiled: February 1, 1985Date of Patent: January 6, 1987Assignee: Sawai Pharmaceutical Co., Ltd.Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
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Patent number: 4617292Abstract: A pharmaceutical composition for producing antiallergic activity containing as an active ingredient a certain tocopherol derivative having a sugar residue at 6-position of the 3,4-dihydrobenzopyrane ring thereof. A method for producing antiallergic activity using such a tocopherol derivative and some novel tocopherol derivatives are also disclosed.Type: GrantFiled: July 17, 1985Date of Patent: October 14, 1986Assignee: Sunstar Kabushiki KaishaInventors: Toshio Satoh, Hideki Miyataka, Yukimitsu Masamoto, Takashi Asai, Kenji Hasegawa, Hisao Kakegawa