Abstract: A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide: (1) X-(Pro-Y-Gly)n-OH, wherein: X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Y represents Pro or Hyp, and n denotes an integer of 1 to 20; (2) X-(Z)r—OH, wherein X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Z represents a peptide chain comprising 1 to 10 amino acid residue(s), and r denotes an integer of 1 to 20; and (3) H2N—R—NH2, wherein R represents a linear or branched alkylene group; and further wherein the ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %); provided that in the case where X represents the group HOOC—(CH2)m—CO— and m has the same meaning as defined above in formula (1) and/or (2), the amount of compou

Abstract: A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where “X” represents HOOC—(CH2)m—CO— in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B).

Abstract: The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5×104 to 100×104 in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.

Abstract: The present invention provides a bioapplicable material (or composition) or film-forming material (or composition), which is free from a risk of an infection by a pathogenic organism or a transmission of a causative factor, has a high safety. The material (or composition) comprises a collagen-like synthetic polypeptide having at least an amino acid sequence represented by the formula -Pro-Y-Gly- (wherein Y represents Pro or Hyp). The polypeptide may show positive Cotton effect at a wavelength in range of 220 to 230 nm and negative Cotton effect at a wavelength in range of 195 to 205 nm in a circular dichroism spectrum. At least part of the polypeptide may be capable of forming a triple helical structure. The polypeptide may be degradable with a collagenase.

Abstract: The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a; (2) [—(OC—(CH2)m—CO)q-(Z)r-]b; and (3) [—HN—R—NH—]c, wherein “m” is 1-18 , “p” and “q” are identical or different, and each is 0 or 1 , “Y” is Pro or Hyp, and “n”1-20 ; “Z” is a peptide chain comprising 1-10 amino acids, “r”1-20 , and “R” is a linear or branched alkylene group; the molar ratio of “a” to “b”[a/b] is 100/0 to 30/70 ; when p=1 and q=0, c=a, when p=0 and q=1, c=b, when p=1 and q=1, c=a+b, and when p=0 and q=0, c=0; and the polypeptide shows a peak of molecular weight in a range from 1×104 to 100×104 in the molecular weight distribution.

Abstract: A method for producing a composite oxide catalyst for gas phase catalytic oxidation of an unsaturated aldehyde with a molecular oxygen-containing gas to produce the corresponding unsaturated carboxylic acid in good yield, is presented. A method for producing a composite oxide catalyst, which is a method for producing a composite oxide catalyst having the following formula (I), characterized in that Sb2O3 of isometric system is used as at least a part of an antimony-supplying source compound: Mo12XaVbSbcCudSieCfOg ??(I) (wherein the respective components and variables have the following meanings: X is at least one element selected from the group consisting of Nb and W; a, b, c, d, e, f and g represent atomic ratios of the respective elements, and against 12 of molybdenum atom, 0<a?10, 0<b?10, 0<c?5, 0<d?5, 0?e?1,000, and 0?f?1,000, and g is a number determined by the degrees of oxidation of the above respective components.

Abstract: A method for producing a composite oxide catalyst for gas phase catalytic oxidation of an unsaturated aldehyde with a molecular oxygen-containing gas to produce the corresponding unsaturated carboxylic acid in good yield, is presented. A method for producing a composite oxide catalyst, which is a method for producing a composite oxide catalyst having the following formula (I), characterized in that Sb2O3 of isometric system is used as at least a part of an antimony-supplying source compound: Mo12XaVbSbcCudSieCfOg ??(I) (wherein the respective components and variables have the following meanings: X is at least one element selected from the group consisting of Nb and W; a, b, c, d, e, f and g represent atomic ratios of the respective elements, and against 12 of molybdenum atom, 0<a?10, 0<b?10, 0<c?5, 0<d?5, 0?e?1,000 and 0?f?1,000, and g is a number determined by the degrees of oxidation of the above respective components.

Abstract: A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where “X” represents HOOC—(CH2)m—CO— in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B).

Abstract: A medical polymer gel produced by immobilizing a drug onto a water swelling polymer gel through a cleavable group with the main chain to be cleaved via an enzymatic reaction and a spacer, and a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. Because the medical polymer gel exerts a drug releasing property depending on the level of an enzyme, the gel can release a therapeutically effective dose of a drug only at a focal lesion generating the enzyme. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.

Abstract: The present invention provides a wound dressing composed of a hydrogel with the principal component being a vinyl alcohol polymer of a viscosity average polymerization degree of 300 or more, wherein the vinyl alcohol polymer contains 5 to 50 mol % of one or more vinyl ester units represented by the following formula (I): ##STR1## and the vinyl alcohol polymer has a block character (.eta.) of 0.6 or less, the block character being represented by the following mathematical formula (II);.eta.=?OH, VES!/2?OH!?VES! (II)Because the wound dressing of the present invention is excellent in terms of transparency, flexibility, hot water resistance, water absorption, and safety, the dressing is useful for the treatment and promotion of the healing of wounds including general wounds such as abrasions, cuts and acne; surgery wounds such as excision wounds and dermabrasions; burns; ulcers; and pressure sores.

Abstract: A water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.

Abstract: A method for determining air borne bacteria which includes successive steps of passing a volume of air by a timed suction pump through a membrane filter at a membrane passing velocity of not more than 15 cm/sec and under a constant transmembrane pressure of not more than 100 mmHg to collect the air borne bacteria on the surface of the membrane filter. The membrane filter has a multiplicity of minute holes and is provided on a medium-absorbing pad housed in a holder. A medium is injected into the medium-absorbing pad housed in said holder. The bacteria thus collected are incubated and the number of the colonies developed on the surface of said membrane filter is measured.

Abstract: A terpolymer whose backbone chain is composed of the following building units is described: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each is H or an alkyl group selected from among CH.sub.3 and C.sub.2 H.sub.5.Further, a polyelectrolyte made either of a terpolymer or of a derivative thereof is also described.