Patents by Inventor Hisao Masai

Hisao Masai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probe for visualizing cell-cycle
    Patent number: 8182987
    Abstract: An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real time. The object of the embodiment of the present invention is attained by providing a method for performing phase identification of the cell cycle, the method including: visualizing one or more gene-expression products as markers whose amounts in a cell change in a cell-cycle dependent manner; and detecting the products so as to distinguish the proliferation phase of the cell cycle from the resting phase thereof.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: May 22, 2012
    Assignees: Tokyo Metropolitan Institute of Medical Science, Riken
    Inventors: Atsushi Miyawaki, Asako Sawano, Hisao Masai
  • PROBE FOR VISUALIZING CELL-CYCLE
    Publication number: 20100100977
    Abstract: An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real time. The object of the embodiment of the present invention is attained by providing a method for performing phase identification of the cell cycle, the method including: visualizing one or more gene-expression products as markers whose amounts in a cell change in a cell-cycle dependent manner; and detecting the products so as to distinguish the proliferation phase of the cell cycle from the resting phase thereof.
    Type: Application
    Filed: February 6, 2008
    Publication date: April 22, 2010
    Inventors: Atsushi Miyawaki, Asako Sawano, Hisao Masai
  • Cdc7-ask kinase complex, substrates of the kinase complex, antibody specific to the substrate, and method of screening compound capable of inhibiting cdc7-ask kinase using the same
    Publication number: 20050250166
    Abstract: The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex can also be evaluated based on these measurement methods. Compounds that inhibit this phosphorylation activity are useful as anti-cancer agents having superior specificity for cancer.
    Type: Application
    Filed: March 12, 2003
    Publication date: November 10, 2005
    Applicant: Medical and Biological Laboratories Co. Ltd.
    Inventors: Hisao Masai, Katsuyuki Tamai
  • Human H37 proteins and cDNA encoding the same
    Patent number: 6897054
    Abstract: This application provides human H37 protein having an amino acid sequence of SEQ ID NO: 1 or NO: 2; human gene encoding the protein; cDNA of the human gene which has a base sequence of SEQ ID NO: 3 or NO: 4; DNA fragment comprising a partial sequence of the cDNA; recombinant vector having the cDNA; antibody against human H37 protein; and a method for controlling the proliferation of cells by introducing the above DNA or antibody into the cells.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: May 24, 2005
    Assignee: Japan Science and Technology Agency
    Inventors: Kenichi Arai, Hisao Masai