Patents by Inventor Hisao Ona

Hisao Ona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing halomethylcarbapenems
    Patent number: 5064954
    Abstract: A functionallized intermediate for antibacterial carbapenems, 2-halomethylcarbapenem (III) is effectively synthesized by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent to give 2-phosphoryloxymethylcarbapenem (II) and then treating this product with a halogenating reagent. Some carbapenems derived from the intermediate are also disclosed. ##STR1## wherein, R.sup.1 is hydrogen or substituted or unsubstituted alkyl;R.sup.2 is hydrogen or substituted or unsubstituted alkyl;R.sup.3, R.sup.4 is halogen or substituted or unsubstituted alkoxy or aryloxy;R.sup.5 is hydrogen or carboxy protecting group; andHal is halogen.
    Type: Grant
    Filed: October 10, 1990
    Date of Patent: November 12, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Shoichiro Uyeo, Mitsuru Imuta, Hisao Ona, Hikaru Itani